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Bioactive porous poly-ether-ether-ketone as well as preparation method and application thereof

A polyetheretherketone and biologically active technology, which is applied in the field of bioactive porous polyetheretherketone material and its preparation, can solve the problems of lack of osteoconduction and bone integration performance and application limitations, and achieve good sustained release effect and drug loading Convenience, good antibacterial effect

Active Publication Date: 2020-11-17
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the bioinert and hydrophobic surface of PEEK itself limits its application in the field of orthopedic implants. Bioinert PEEK materials do not have good osteoconduction (Osteoconduction) and osseointegration (Osseointegration) performance, as bone implant materials After being implanted in the body, it does not respond well to the surrounding bone tissue and is tightly combined with the bone. On the contrary, a layer of fibrous tissue will be produced to wrap the PEEK implant material

Method used

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  • Bioactive porous poly-ether-ether-ketone as well as preparation method and application thereof
  • Bioactive porous poly-ether-ether-ketone as well as preparation method and application thereof
  • Bioactive porous poly-ether-ether-ketone as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0039] (1) All the raw materials in the example are commercially available. Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3 to make hydroxyapatite Stone microspheres are evenly adhered to the surface of NaCl particles and sintered at 700°C for 2 hours to construct composite porogenic particles;

[0040](2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0041] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0042] (4) Pr...

Embodiment 2

[0045] (1) Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3, so that the hydroxyapatite microspheres evenly adhere to the NaCl particles On the surface, sinter at 700°C for 2 hours to construct composite porogenic particles;

[0046] (2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0047] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0048] (4) Prepare 10mg / ml BMP-2 solution, keep the negative pressure adsorption at ...

Embodiment 3

[0051] (1) Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3, so that the hydroxyapatite microspheres evenly adhere to the NaCl particles On the surface, sinter at 700°C for 2 hours to construct composite porogenic particles;

[0052] (2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0053] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0054] (4) Prepare icariin solution of 10mg / ml, keep the negative pressure adsorptio...

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Abstract

The invention relates to a bioactive porous poly-ether-ether-ketone material and a preparation method and application thereof. The active porous poly-ether-ether-ketone material has a pore diameter of450-800 [mu] m and a porosity of 30-95%, and hydroxyapatite microspheres are contained on the inner surfaces of pores. The preparation method comprises the following steps: uniformly adhering the hydroxyapatite microspheres to the surfaces of NaCl particles, performing sintering to obtain composite pore-forming particles, uniformly mixing the composite pore-forming particles with poly-ether-ether-ketone, performing compacting, performing sintering, and finally removing NaCl to obtain the porous poly-ether-ether-ketone material. Osteogenesis promoting medicines and antibacterial medicines canbe loaded into the material according to needs, and the hydroxyapatite microspheres on the inner surface are added, so that the bioinertness of the poly-ether-ether-ketone can be effectively improved,the poly-ether-ether-ketone has bioactivity, the medicines and growth factors can be loaded, a good slow release effect is achieved, and good osteogenesis promoting and antibacterial properties are achieved. The bioactive porous poly-ether-ether-ketone material disclosed by the invention has the advantages of simple process, low cost, controllable structure, convenient drug loading and the like.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a bioactive porous polyetheretherketone material and its preparation method and application. The inner surface of the material has an active hydroxyapatite layer, which can be loaded by adsorption Osteogenic drugs and antibacterial drugs are mainly used in artificial bone repair and bone transplantation. Background technique [0002] Polyetheretherketone (poly-ether-ether-ketone, referred to as PEEK), as a special engineering plastic with excellent performance, is widely used in trauma, prosthesis, orthopedic implants and other medical fields. Compared with titanium alloy and stainless steel, etc. Traditional metal implants, PEEK has good biological properties. As early as 20 years ago, the biocompatibility of polyether ether ketone was proved. No cytotoxicity was found in the process of co-cultivation of cells. Its biological Security is well guaranteed. Moreover, PEEK can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/32A61L27/56A61L27/54C08J9/26C08L61/16
CPCA61L27/18A61L27/32A61L27/56A61L27/54C08J9/26C08J2361/16C08J2201/0444A61L2300/404A61L2300/412A61L2300/602C08L61/16
Inventor 张立群谢纹奇石锐吴丝竹路欣
Owner BEIJING UNIV OF CHEM TECH
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