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Graded porous scaffolds as immunomodulatory wound patches

A technology of grading porous and porous materials, applied in the direction of non-active components of polymer compounds, prostheses, bandages, etc.

Active Publication Date: 2020-02-14
TEMPLE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Application of bioengineered scaffolds in animal models appears to play a role in the repair of skin appendages, which has not been reported in skin wounds treated with the other two techniques (Har-el Y et al., Wound Medicine 5(2014) :9-15; Sundaramurthi D et al., Polymer Reviews 54.2(2014):348-376)

Method used

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  • Graded porous scaffolds as immunomodulatory wound patches
  • Graded porous scaffolds as immunomodulatory wound patches
  • Graded porous scaffolds as immunomodulatory wound patches

Examples

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Embodiment 1

[0093] Example 1: Graded Hydration Lyophilized (GHL) Scaffold

[0094] The purpose of this study is to develop a fibrous scaffold with large enough pores to allow cells to penetrate into the depth of the scaffold, which is reported to initiate / promote the phenotype of macrophages to switch to the tissue remodeling M2 phenotype and thereby enhance regeneration Wound healing (Garg K et al., Biomaterials 34.18(2013): 4439-4451; Wang Z et al., Biomaterials 35.22(2014): 5700-5710; Sussman EM et al., Annals of biomedicalengineering 42.7(2014): 1508-1516).

[0095] The main component of the fibrous scaffold is purified soy protein isolate (SPI), which is a paradigmatic biocompatible biomaterial that has been shown to allow cells to attach, diffuse and proliferate in vitro (LinL et al. , Journal of tissue engineering and regenerative medicine 7.12(2013):994-1008). The sacrificial component of the stent is polyethylene oxide (PEO), which is a cheap polymer compound, easily available and...

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Abstract

The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.

Description

[0001] Cross references to related applications [0002] This application claims priority from U.S. Provisional Patent Application No. 62 / 490,148 filed on April 26, 2017, the content of which is incorporated herein by reference in its entirety. Background technique [0003] Chronic wound care imposes a huge financial burden on the US healthcare system and individual payers. Currently, the annual costs associated with non-healing / difficult-to-heal skin wounds total approximately US$25 billion (Witherel CE et al., Wound Repair and Regeneration 24.3(2016):514-524). However, despite all the costs, the patient's needs for a normal life without any pain or scars are hardly met. Although autologous transplantation is one of the most commonly used methods for skin replacement, there are still problems with size limitations in terms of morbidity, mortality, and the area of ​​donor skin that can be used for transplantation. [0004] Alternative treatment methods include the application of bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/56A61K47/42
CPCA61L27/227A61L27/56A61L27/60A61L2400/08D01D5/003A61L15/425A61L27/38A61L15/32A61L27/26D10B2509/022
Inventor 阿扎德·蒂姆纳克彼得·I·莱尔凯斯耶-艾尔·H·哈尔-艾尔
Owner TEMPLE UNIVERSITY
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