89results about How to "Protect liver function" patented technology

This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin D receptor agonists precursors) for the treatment of liver fibrosis. Also disclosed are methods for screening for agents that treat, prevent, and ameliorate fibrosis.

The invention discloses a blood lipid-reducing health-care product, which is prepared by mixing the following components in percentage by weight: 50 to 60 percent of natto flour, 25 to 35 percent of fiveleaf gynostemma herb, 1.5 to 2.5 percent of lentinan, 3 to 6 percent of puerarin, and 8 to 15 percent of tea polyphenol. The blood lipid-reducing health-care product can regulate blood lipid, clean blood vessels, reduce blood viscosity, improve and relieve vascular fibrosis, protect liver functions, reinforce cardiocerebral activities, reduce triglyceride, cholesterol and glutamic-pyruvic transaminase, promote density lipoprotein, restore carrier protein defects, delay aging and the like.

The invention discloses application of a Jingfang preparation in preparation of a medicine for treating sequelae of the novel coronavirus disease and a preparation method thereof, and belongs to the field of medicines. The Jingfang preparation is prepared from eleven raw medicinal materials such as fineleaf schizonepeta herb, divaricate saposhnikovia root, notopterygium root, doubleteeth pubescentangelica root, Chinese thorowax root, common hogfennel root, szechuan lovage rhizome, bitter orange, Indian buead, platycodon root and liquoric root, and has the effects of sweating, relieving exterior, dispersing wind and removing dampness. The Jingfang preparation is an effective formula for treating sequelae of the novel coronavirus disease, can effectively treat viral myocarditis of patientswith the novel coronavirus disease in the convalescence, reduce the serum concentration of liver function markers ALT and AST and renal function markers Cre and BUN, thereby effectively protecting liver and kidney functions, effectively inhibit inflammatory response of acute respiratory distress syndrome and effectively treat diarrhea. Both symptoms and root causes are treated, and definite therapeutic effect is achieved on the sequelae of the novel coronavirus disease.

The invention discloses novel garlic nutritive salt and a preparation method thereof. The novel garlic nutritive salt comprises edible salt serving as the main component and 0.1-30wt% of garlic nutrients. The novel garlic nutritive salt has the advantages that the original special smell and nutrients of garlic are kept in the salt, the eating effect of the garlic is brought into play while seasoning for cooking is achieved, and the salt can prevent and treat tumor, prevent diabetes, protect the liver, prevent cold, and the like. The preparation method has the advantages that the raw materials are food, the pure biomass preparation method is nontoxic, harmless, safe and free of side effect, and the garlic nutrients are kept, and the preparation method is simple, practicable and worthy of popularization.

The invention discloses a traditional Chinese medicine composition for treating an autoimmune liver disease, and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-30 parts of cooked rhubarb, 10-30 parts of glossy privet fruit, 10-30 parts of radix curcumae, 10-30 parts of large-leaved gentian, 10-30 parts of caulis spatholobi, 10-30 parts of caulis sinomenii, 10-30 parts of radix rubiae, 10-30 parts of sedum sarmentosum and 5-15 parts of liquorice. The traditional Chinese medicine has the effects of strengthening body resistance, detoxifying, dispersing stagnated liver qi for promoting bile flow, promoting blood circulation to remove blood stasis, expelling wind and removing dampness; the main treatment range comprises autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and overlap syndrome of any two in the three diseases; and the traditional Chinese medicine composition has the treatment effects of restoring immune balance, inhibiting liver inflammation, protecting liver function, resisting hepatic fibrosis, improving clinical symptoms, improving survival quality and the like, and has high safety.

The invention discloses a medicine for treating qi-yin deficiency type diabetes mellitus and a preparation method thereof and relates to the technical field of preparation of diabetes mellitus medicines. The medicine is prepared from the following raw materials in parts by weight: 20 to 30 parts of radix notoginseng, 20 to 30 parts of dendrobium officinale kimura ex migo, 20 to 30 parts of bittergourd, 25 to 35 parts of radix astragali seu hedysari, 20 to 30 parts of radix puerariae, 10 to 20 parts of American ginseng root, 20 to 30 parts of radix et rhizoma salviae miltiorrhizae, 25 to 35 parts of radix ophiopogonis, 10 to 20 parts of herba cistanches, 15 to 25 parts of rhizoma polygonati odorati, 10 to 20 parts of endothelium corneum gigeriae galli, 15 to 25 parts of ramulus euonymi, 7to 15 parts of semen persicae and 15 to 25 parts of rhizoma polygonati. Aiming at qi-yin deficiency symptoms at a middle period of the diabetes mellitus, various Chinese medicinal herbs are matched according to syndrome differentiation and have a common effect to realize the effects of nourishing yin and moistening dryness, reinforcing spleen and strengthening qi, clearing away heat and tonifyingkidney; the qi-yin deficiency symptoms of patients are effectively improved and a blood glucose level is reduced; the curative effect is remarkable and lasting; the medicine is papered from the pure Chinese medicinal herbs, is safe and has no side effect; the preparation method is simple and the effect of treating both principal and secondary aspects of the diabetes mellitus can be realized.

The invention provides aspartate of vortioxetine or hydrate thereof, comprising anhydrous crystal form, semihydrate crystal form and dihydrate crystal form of aspartate of vortioxetine, as well as a preparation method and application thereof. The preparation method comprises the following steps: performing a reaction on the vortioxetine and the aspartic acid in the organic solvent or the mixed solvent of the organic solvent and the water for generating the aspartate, keeping the temperature or cooling and crystallizing. The aspartate of the vortioxetine has the function of treating major depressive disorder and also has the function of the aspartic acid, so that the defect of the inorganic acid salt to the human body is effectively compensated by the aspartate. The solubility, stability and bioavailability of the aspartate are greatly improved. The equilibrium solubility shows that the solubility of the aspartate of the vortioxetine (at 37 DEG C) is more than 7 times of that of the hydrobromide of the vortioxetine.

The invention relates to a Chinese medicine with the functions of eliminating lipid and removing heat from the liver and a preparation method thereof. The Chinese medicine is a preparation prepared by giant knotweed, hawthorn, rhubarb, herba artemisiae capillaris and radix bupleuri in proportion. The preparation method is as follows: 1) giant knotweed, hawthorn and rhubarb are taken and extracted with ethanol in a fractionated manner, the extract is merged, the dreg mixture of the three raw materials is separated out by filtering, and after ethanol is recovered, the filtrate is concentrated into the thick extract of the three raw materials; 2) herba artemisiae capillaris and radix bupleuri are taken and merged with the dreg mixture and decocted with distilled water in a fractionated way, decoction is merged and filtered, and the obtained filtrate is concentrated into the thick extract of the five raw materials: 3) the thick extract of the three raw materials and the thick extract of the five raw materials are merged, treated with spray drying, pulverized into fine powder and prepared into pulvis, granules, tablets or capsules. The Chinese medicine can alleviate hyperlipaemia, reduce fat accumulation in the liver and fatty degeneratiaon degree, protect liver function and maintain energy equilibrium of the body, and has the advantages of definite curative effect, few toxic and side effects and safe and reliable performance.

The invention discloses a functional sea food for protecting liver and enhancing immunity, which is prepared from raw materials including sodium alginate and taurine, and has the advantages of evident effect and no toxic and side actions.

The invention provides a bolete-tremella blood pressure-reducing health-care rice cake. The rice cake is prepared from the following components by weight: 90 to 100 parts of glutinous rice, 8 to 10 parts of brown rice, 10 to 12 parts of kidney bean, 12 to 15 parts of chickpea, 3 to 4 parts of greens, 5 to 6 parts of cauliflower, 8 to 10 parts of collard, 6 to 8 parts of spinach root, 10 to 12 parts of bolete, 6 to 8 parts of common morel, 5 to 6 parts of saddle fungus, 5 to 7 parts of Pleurotus tuber-regium, 4 to 6 parts of Lactarius deliciosus, 3 to 4 parts of poria cocos, 6 to 8 parts of tremella, 3 to 4 parts of kelp base, 2 to 4 parts of polygonatum rhizome, 3 to 4 parts of cinnamon, 2 to 4 parts of dahurian angelica root, 1 to 2 parts of eucommia, 3 to 4 parts of licorice, 2 to 3 parts of epimedium, 3 to 4 parts of ginkgo bud-leaf, 2 to 3 parts of saffron, 2 to 4 parts of gynostemma pentaphylla and 0.01 to 0.02 part of lycium barbarum polysaccharide. The health-care rice cake provided by the invention has delicate taste and fragrant smell and the effects of enriching yin, nourishing kidney, strengthening stomach, promoting digestion, reducing lipid and adjusting immunity of people and is applicable to a variety of populations.

The invention provides antibacterial medical hemostasis absorbent cotton gauze, which consists of medicine dressing and a tissue material carrying the medicine dressing, wherein the medicine dressingis prepared from traditional Chinese medicine and western medicine; the tissue material carrying the medicine dressing is blended by scleroprotein fiber and cotton fiber. The hemostasis and the antibacterial effects are integrated; the obvious effects are achieved on abnormal bleeding in operations of lung, liver, pancreas, adrenal gland and the like, the bleeding except for obstetrics departmentand postpartum hemorrhage, urinary tract bleeding and the like; in addition, the antibacterial medical hemostasis absorbent cotton gauze can be used under the conditions of great and deep wound and great bleeding quantity; the hemostasis is fast; the wound surface wound recovery is facilitated; meanwhile, the antibacterial spectrum is wide; the sterilization power is strong; the action is fast; the effectiveness can also be achieved on pseudomonas aeruginosa, klebsiella, escherichia coli, enterobacter, staphylococcus, mycoplasma and chlamydia; in addition, good effects are achieved on trimethoprim drug resistant bacteria, penicillin drug resistant staphylococcus aureus andtylosin or tiamulin drug resistant mycoplasma.

A food for supplementing estrogen to human body and regulating the intenstinal bacilli is prepared from soybean isoflavone, bifidobacteria, lactolin and VC1.

The invention belongs to the field of traditional Chinese medicine production and relates to an application of Cordyceps sobolifera water extract in preparation of an acute liver injury preventing and treating drug. Based on D-galactosamine / lipopolysaccharide induced acute liver injury model experiments, results prove that the Cordyceps sobolifera water extract can relieve lipid peroxidation and oxidative stress injury of liver cells by reducing transaminase (AST and ALT) and alkaline phosphatase (ALP) in serum, remarkably relieves infiltration of inflammatory factors of the liver and improves liver lesion obviously, meanwhile, the Cordyceps sobolifera water extract can relieve infiltration of neutrophils in the liver, inhibit transcription and expression of related inflammatory mediators, reduce inflammation induced inflammatory factor and NO release and inhibit MAPK (mitogen-activated protein kinases) pathway activation. The Cordyceps sobolifera water extract can be used for preparing the acute liver injury preventing and treating drug and is used for protecting liver function and relieving liver inflammation.

The invention provides a preparation for rapid treatment of fatty liver. The preparation is prepared from the following herbal raw materials: Abrus cantoniensis, Semen Sinapis, Allium macrostemon, filiform cassytha herb, Elsholtzia blanda, Asparagus cochinchinensis, radix angelicae pubescentis, Phyllanthus urinaria, Hedyotis diffusa, scutellaria baicalensis, ginger, Elsholtzia ciliata, Fritillaria thunbergii, Polygala japonica, seaweed, Chinese Buckeye Seed, chicken's gizzard-membrane, Amomum kravanh, Poncirus trifoliate, Cortex Lycii, Curcuma zedoaria, ruddle, dragon bone, and Swertia bimaculata. The preparation for rapid treatment of fatty liver provided by the invention selects medicinal materials with appropriate compatibility, is accord with the theories of traditional Chinese medicine and pharmacy and modern medicine and pharmacology, all the medicinal materials are compatible, and can jointly achieve the efficacy of lowering lipid and benefiting liver, tonifying Yin and dispersing blood stasis, nourishing yin for lowering fire, activating stagnancy and dredging vessels. With significant curative effect on fatty liver, the preparation provided by the invention has the advantages of safety and reliability, quick effect, convenient oral administration, no toxic or side effect and no recurrence after cure, can achieve the purpose of treating both symptoms and root causes, effectively eliminates or alleviates infiltration of fat in liver, protects the liver function, reduces blood lipid, and is worthy of wide promotion and application in clinical practice.

The invention relates to a production method of a traditional Chinese medicine moxa stick with the effects of liver soothing and qi smoothing. The traditional Chinese medicine moxa stick comprises, by weight percentage, 70-85% of three-year-aged moxa and 15-30% of traditional Chinese medicine powder. The traditional Chinese medicine powder comprises, by weight, 3-7 parts of bupleurum, 3-7 parts of radix curcumae, 8-12 parts of oriental wormwood, 3-7 parts of costusroot, 3-7 parts of rhizoma cyperi, 3-7 parts of pericarpium citri reticulatae viride, 3-7 parts of cape jasmine and 8-12 parts of felwort. The production method includes: taking traditional Chinese medicine according to the weight, smashing into powder, sieving through a 100-mesh sieve, mixing into the traditional Chinese medicine powder, and mixing the traditional Chinese medicine powder into the moxa according to the weight percentage to produce the moxa stick. The moxa stick can be used to perform moxibustion on targeted acupoints, is high in targeting performance, and can nurse and treat people with diseases such as depression, insomnia and dysphoria, anorexia, swelling pain on two sides of the chest, chest suppression, dryness-heat and irritability, unhappiness and menstrual period stomachache.

The invention belongs to the technical field of medicine and relates to a pharmaceutical composition with liver protective function. The pharmaceutical composition is composed of saikoside A and taurine; the composition is prepared by supplementing the routine pharmaceutical adjuvants in a routine process. The invention further discloses application of the pharmaceutical composition in preparation of a medicine for treating and / or preventing the acute liver injury or relieving the chronic liver injury. The pharmaceutical composition has an obvious effect for preventing the acute liver injury or reducing the chronic liver injury.

The invention discloses traditional Chinese medicine bath manipulation external decoction for treating neonatal jaundice and preparation and using methods of the traditional Chinese medicine bath manipulation external decoction. The traditional Chinese medicine bath manipulation external decoction is prepared from the following crude drugs in percentage by weight: herba artemisiae scopariae, fructus gardenia, Radix et Rhizoma Rhei, radix glycyrrhizae, Rhizoma Acori Graminei, radix curcumae, radix scutellariae, herba pogostemonis, Mangnolia officinalis, radix salviae miltiorrhizae, herba eupatorii, rhizoma atractylodis and radix paeoniae rubra; after all the crude drugs are weighed according to the weights, water is added for soaking, and then liquid decocting through a drug-decocting machine, residue filtering and packaging are conducted, so that the external decoction in bags is prepared; and during using, the decoction is adopted and added with warm water, bathing is conducted for 20-40 minutes every time, after bathing is completed, the body is wipe-dried to be manipulated for 40-80 minutes, and after navel disinfection, treating is completed. The traditional Chinese medicine bath manipulation external decoction is prepared from pure traditional Chinese medicines and absorbed through the skin, has the function of strengthening the spleen and stomach, and has the effects of promoting discharging of bilirubin, clearing heat and benefiting the gallbladder, and removing toxins and jaundice, the treating effective rate reaches 97%, and thus the traditional Chinese medicine bath manipulation external decoction for treating neonatal jaundice is simple, convenient, easy to implement and good in treating effect.

The invention discloses a new application of small-molecular citrus pectin. The small-molecular citrus pectin can be used for preparing anti-tumor auxiliary medicines which have immunoregulation effects and can be used for cooperating with the effect-enhancing and toxicity-reducing action of chemotherapy medicines, or can be used for preparing health products with anti-tumor auxiliary effects. A compound disclosed by the invention cannot be used for directly killing tumor cells when being separately used, and does not have anti-tumor effects; the compound can be taken as an auxiliary medicine, can cooperate with the chemotherapy medicines for use, can have immunoregulation functions on T cells and MDSC cells by virtue of ligands on the surfaces of antagonistic immune cells and tumor tissue cells of the compound, can be used for enhancing the anti-tumor effects in an auxiliary mode, and ensures that the sensitivity-enhancing and toxicity-reducing effects on tumor chemotherapy can be achieved; and new medical applications of the known compound namely the small-molecular citrus pectin can be explored, and a new application field can be created.

The invention discloses a mixed feed for improving the post-weaning estrus rate of sows in summer. Every 1000 kg of the mixed feed comprises 600-680 kg of corn, 30-70 kg of soybean meal, 40-60 kg of fermented soybean meal, 80-120 kg of expanded soybean, 55-80 kg of corn germ meal, 40-55 kg of apple pomace, 10-13 kg of stone flour, 10-13 kg of calcium hydrogen phosphate, 2-3 kg of lysine, 0.2-0.4 kg of methionine, 0.8-1.0 kg of threonine, 1.7-2.0 kg of tryptophan, 0.2-0.4 kg of chitosan oligosaccharides, 0.4-0.7 kg of plant extract, 0.4-0.6 kg of a mildew inhibitor and 8-10 kg of a premix. Themixed feed is applied in a period from seven days before weaning of the sows in summer to estrus, can effectively increase the feed intake of the sows, reduce the heat stress reaction and inflammationproblems of the sows and improve the post-weaning estrus rate of sows in summer, and is of great significance to actual production.

The invention relates to anti-inflammatory effect of novel anti-inflammatory molecular DRP, an implementation method and application, in particular to application of death resistant protein (DRP) in resisting bacterial infection and an application method. The invention provides the application method of the molecule in resisting bacterial infection and a corresponding immunological principle. The invention discloses application and strategy of the molecule in resisting the bacterial infection, particularly in preventing and treating infectious shock and endotoxic shock caused by the bacterial infection. The invention proves that the molecule can inhibit the generation of inflammatory factors after the bacterial infection, improve the survival rate of bodies in the endotoxic shock and protect the infected organs such as liver and the like from inflammation injury.

A medicine contains aspirin, red koji extrat, liver-protecting medicine, dihydroxyaluminium aminoacetate, heavy magnesium carbonate and / or magnesium aluminate carbonate. A packing box is also disclosed, which contains 60 tablets of red koji extract and 60 tablets of aspirin.

The invention provides a traditional Chinese medicine composition for preventing and / or treating fatty liver, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 15 parts of radix ginseng rubra, 10 to 30 parts of radix et rhizoma rhei, 20 to 50 parts of radix astragali, 20 to 50 parts of herba epimedii, 20 to 35 parts of rhizoma chuanxiong, 10 to 30 parts of unprocessed radix rehmanniae, 10 to 30 parts of herba artemisiae scopariae, 10 to 30 parts of herba sedi sarmentosi, and 15 to 40 parts of turtle shell. According to the embodiment of the invention, the traditional Chinese medicine composition for treating the fatty liver has the advantages that the effective rate for treating fatty liver reaches 83.88%; the effective rate for treating II diabetes combined with nonalcoholic fatty liver is 64.86%.

The invention discloses a miR-451a antisense strand inhibitor and an application thereof. According to the invention, a mouse model with alcoholic liver disease is established, deep sequencing of small RNA on the liver tissues of a model group and a normal control group can be performed, the differentially expressed miR-451a can be analyzed and screened, and qRT-PCR is used for verification. the miR-451a antisense strand inhibitor is chemically synthesized, in-vivo experiments in mice is carried out, the results show that the miR-451a antisense strand inhibitor effectively reduces ALT and glutamic-pyruvic transaminase AST in serum of mice with alcoholic fatty liver disease, and the accumulation of fat in the liver is significantly reduced, which indicates that the miR-451a antisense chaininhibitor can protect liver function and alleviate alcoholic fatty liver disease. The miR-451a antisense strand inhibitor is expected to be developed as a new small molecule RNA drug for the treatmentof alcoholic fatty liver disease.

The invention provides a feed addictive for preventing fatty liver of grass carp. The feed addictive comprises raw materials in percentage by weight as follows: 40%-60% of a Chinese medicine fermentedextract, 20%-30% of betaine and 5%-10% of vitamins, wherein the Chinese medicine fermented extract is mainly prepared by the fermentation of capillary wormwood herb, flaccid knotweed herb, spirulina,green tea, plantain herb and a tangerine peels with lactobacillus acidophilus and saccharomyces cerevisiae. The feed addictive can be directly added in the fish feed to reduce fat depositions in fish, maintain normal physiological function of liver tissue, promote digestion and feeding of the grass carp and increase the edible proportion of grass carp.

The invention relates to a medicinal composition comprising effective dose of red yeast rice extract and at least a medicament for resisting platelet aggregation, especially compound medicinal preparation of Clopidogrel red yeast rice extract and its use, the preparation can also contain right amount of liver-protective agent, and at least one kind of pharmaceutically acceptable excipient.

The invention discloses a puerarin-proline eutectic crystal and a preparation method thereof, and particularly relates to two puerarin pharmaceutical eutectic crystals and a preparation method thereof, the pharmaceutical eutectic crystals take puerarin as a pharmaceutical active ingredient (API), a selected eutectic crystal forming matter is L-proline, the puerarin is connected with the proline through a hydrogen bond, and the proline is connected with the puerarin through a hydrogen bond. The molar ratio of the two co-crystals is 1: 1 and 2: 1 respectively, the solvents selected in the preparation process of the pharmaceutical co-crystal are alcohol and water, the adopted crystallization method is a cooling crystallization method, and the prepared co-crystal inherits the pharmacological activity of puerarin and is obviously improved in the aspects of solubility, dissolution rate, stability and the like.

A medicine contains red koji extract, liver-protecting medicine, skeleton material and medicinal additive. A packing box is also disclosed, which includes 60 tablets of red koji extract and 60 tablets of liver-protecting medicine.

The invention belongs to the field of medical and health care, and specifically provides a clinical nutrient for liver diseases. The liver disease clinical nutrient includes protein energy supply components, fat energy supply components and sugar energy supply components, and the energy supply ratio of the three is 17-20:18.5-20:60-64.5. At the same time, the present invention also provides the application of the liver disease clinical nutritional agent of the present invention in the preparation of a composition for treating liver diseases. The beneficial effect achieved is that the clinical nutritional agent for liver disease of the present invention can provide a pretreatment nutritional substrate that meets the special needs of liver disease through targeted nutritional formula adjustment. Reduce the burden on the liver, improve metabolic disorders, protect the existing liver function, and benefit the regeneration of liver cells. Then it can meet the continuous medium and high consumption energy demand of patients with chronic liver disease for long-term treatment, and provide the necessary and key nutritional guarantee for the reconstruction and long-term maintenance of liver-intestinal function.