Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition composed of saikoside A and taurine and use thereof

A technology of saikosaponin and composition, which is applied in the field of medicine to achieve the effect of broadening the range, improving liver metabolism, and enhancing liver protection activity

Inactive Publication Date: 2015-06-10
SHANDONG ACAD OF CHINESE MEDICINE
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The combination of saikosaponin A and taurine is used to improve the hepatoprotective effect of the drug and reduce the hepatotoxic effect of the drug. There is no report or patent disclosure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition composed of saikoside A and taurine and use thereof
  • Pharmaceutical composition composed of saikoside A and taurine and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Preparation of the composition tablet of the present invention

[0026] 1. Prescription:

[0027] Prescription 1

[0028] saikosaponin A 0.2g taurine 100g microcrystalline cellulose 50g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 pieces

[0029] Prescription 2

[0030] saikosaponin A 1g taurine 200g microcrystalline cellulose 60g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 pieces

[0031] 2. Preparation process:

[0032] Raw materials and auxiliary materials were crushed through 80-mesh sieve for later use; preparation of granulation solution: take PVP K30 and add medicinal ethanol with a concentration of 30-95% to make a 5-10% solution; mix raw materials and auxiliary materials, and add appropriate amount of ...

Embodiment 2

[0033] Embodiment 2 The preparation of the capsule of pharmaceutical composition of the present invention

[0034] 1. Prescription:

[0035] Prescription 1

[0036] saikosaponin A 0.5g taurine 100g microcrystalline cellulose 50g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 capsules

[0037] Prescription 2

[0038] saikosaponin A 2g taurine 200g microcrystalline cellulose 60g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 capsules

[0039] 2. Preparation process:

[0040] Raw materials and auxiliary materials were crushed through 80-mesh sieve for later use; preparation of granulation solution: take PVP K30 and add medicinal ethanol with a concentration of 30-95% to make a 5-10% solution; mix raw materials and auxiliary materials, and ad...

Embodiment 3

[0041] Embodiment 3 Preparation of pharmaceutical composition granules of the present invention

[0042] 1. Prescription:

[0043] Prescription 1:

[0044] saikosaponin A 1g taurine 200g powdered sugar 1000g 2%HPMC50% ethanol solution Appropriate amount co-preparation 1000 packs

[0045] Prescription 2:

[0046] saikosaponin A 2g taurine 300g powdered sugar 1200g 2%HPMC50% ethanol solution Appropriate amount co-preparation 1000 packs

[0047] 2. Specific steps:

[0048] Crush the raw materials and auxiliary materials through a 100-mesh sieve, and set aside; weigh the raw materials and auxiliary materials according to the prescription amount, mix the raw materials and powdered sugar in equal amounts, add an appropriate amount of 2% HPMC50% ethanol solution, and stir evenly to prepare Suitable for soft materials, pass through a 20-mesh sieve to granulate, dry at 60°C, pass through a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine and relates to a pharmaceutical composition with liver protective function. The pharmaceutical composition is composed of saikoside A and taurine; the composition is prepared by supplementing the routine pharmaceutical adjuvants in a routine process. The invention further discloses application of the pharmaceutical composition in preparation of a medicine for treating and / or preventing the acute liver injury or relieving the chronic liver injury. The pharmaceutical composition has an obvious effect for preventing the acute liver injury or reducing the chronic liver injury.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of saikosaponin A and taurine in a certain proportion, a preparation method thereof, and an application of the pharmaceutical composition in the preparation of medicines for treating and / or preventing acute liver injury or alleviating chronic liver injury , belonging to the field of medical technology. Background technique [0002] Bupleurum is bitter and cool in nature and taste, enters the liver and gallbladder meridian, reconciles exterior and interior, soothes the liver, and promotes yang. Treatment of alternating cold and heat, chest fullness and hypochondriac pain, bitter mouth and deafness, headache and dizziness, malaria, prolapse of the anus, irregular menstruation, and prolapse of the uterus. Modern pharmacological studies have shown that Bupleurum has various pharmacological activities such as anti-inflammation, immune regulation, anti-hepatic fibrosis and liver protection. In ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16A61P29/00A61K31/185
Inventor 孙蓉毛近隆冯群李晓宇李晓骄阳刘闰平
Owner SHANDONG ACAD OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com