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Medicinal preparation of extractive from compound aspirin and rice fermentred with red yeast

A kind of technology of aspirin and extract, applied in the field of compound pharmaceutical composition

Inactive Publication Date: 2005-08-31
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no other class of drugs that can replace this class of drugs in terms of lowering low-density lipoprotein, treating coronary heart disease, and preventing cardiovascular events.

Method used

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  • Medicinal preparation of extractive from compound aspirin and rice fermentred with red yeast
  • Medicinal preparation of extractive from compound aspirin and rice fermentred with red yeast
  • Medicinal preparation of extractive from compound aspirin and rice fermentred with red yeast

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Prescription: 1000 tablets

[0050] Red Yeast Extract 300g

[0051] Aspirin 20g

[0052] Bifendate 25g

[0053] Aluminum glycylate 6g

[0054] Heavy Magnesium Carbonate 11g

[0055] Microcrystalline Cellulose 105g

[0056] Sodium carboxymethyl starch 20g

[0057] Polyvinylpyrrolidone 8g

[0058] Micronized silica gel 4g

[0059] Magnesium Stearate 2g

[0060] Preparation method: Pass the medicine and auxiliary materials through 80-mesh sieve respectively, weigh the prescription amount of red yeast rice extract, aspirin, bifendate, aluminum glyoxate, heavy magnesium carbonate, microcrystalline cellulose, sodium carboxymethyl starch (2 / 3), mix evenly, make soft material with 10% polyvinylpyrrolidone aqueous solution, cross 16 mesh sieves, dry, granulate, add remaining (1 / 3) sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, It can be directly compressed into tablets.

Embodiment 2

[0061] Example 2: Preparation of Red Yeast Extract+Aspirin+Malotilate Film-Coated Tablets.

[0062] prescription:

[0063] 1000 pieces

[0064] Red Yeast Extract 250g

[0065] Aspirin 25g

[0066] Aluminum glycylate 6g

[0067] Heavy Magnesium Carbonate 11g

[0068] Malotilate 100g

[0069] Microcrystalline Cellulose 67.5g

[0070] Croscarmellose Sodium 20g

[0071] 10% starch slurry appropriate amount

[0072] Micronized silica gel 5g

[0073] Magnesium Stearate 2.5g

[0074] Preparation method: pass the drug and auxiliary materials through 80 mesh sieves, weigh the prescription amount of red yeast rice extract, aspirin, aluminum glycolate, heavy magnesium carbonate, malotilate, microcrystalline cellulose, and cross-linked carboxymethyl cellulose Sodium (2 / 3), mix evenly, use 10% starch slurry to make soft material, pass through 16 mesh sieve, dry, granulate, add remaining croscarmellose sodium, micropowder silica gel, magnesium stearate and...

Embodiment 3

[0075] Example 3: Preparation of Red Yeast Extract + Aspirin + Disodium Adenosine Triphosphate Capsules

[0076] prescription:

[0077] 1000 capsules

[0078] Red Yeast Extract 200g

[0079] Aspirin 40g

[0080] Aluminum glycylate 6g

[0081] Heavy Magnesium Carbonate 11g

[0082] Disodium Adenosine Triphosphate 15g

[0083] Microcrystalline Cellulose 84g

[0084] Polyvinylpyrrolidone 5g

[0085] capsule shell

[0086] Preparation method: pass the medicine and auxiliary materials through 80-mesh sieve respectively, weigh the prescription amount of red yeast rice extract, aspirin, aluminum glycolate, heavy magnesium carbonate, adenosine triphosphate disodium, microcrystalline cellulose, mix evenly, and use 5% poly The soft material is made of vinylpyrrolidone 75% ethanol solution, passed through a 16-mesh sieve, dried, granulated through a 14-mesh sieve, and the drug granules are filled into the capsule shell to obtain the product.

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Abstract

A medicine contains aspirin, red koji extrat, liver-protecting medicine, dihydroxyaluminium aminoacetate, heavy magnesium carbonate and / or magnesium aluminate carbonate. A packing box is also disclosed, which contains 60 tablets of red koji extract and 60 tablets of aspirin.

Description

Technical field: [0001] The invention relates to a compound pharmaceutical composition, in particular, it contains 5 mg-100 mg of aspirin, 10-500 mg of red yeast rice extract, 5-500 mg of liver-protecting medicine, and the composition may also contain 3-33 mg of glyoxate, heavy carbonic acid 5-44 mg of magnesium, or 15-150 mg of aluminum carbonate, and appropriate amount of pharmaceutically acceptable auxiliary materials. [0002] The invention also relates to a packaging box, which contains 60 effective doses of red yeast rice extract, 60 aspirin tablets and 60 tablets of at least one hepatoprotective drug. Background technique: [0003] Small doses of aspirin can inhibit the platelet release response (release caused by adrenaline, collagen, thrombin, etc.) and aggregation reaction (second phase aggregation). It can prolong bleeding time and reduce thrombus formation in vivo. Simultaneous inhibition of cholesterol biosynthesis reduces normal and elevated low-density lipop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/06A61P3/06A61P7/02A61P9/10
Inventor 鄂滟蔡金巧
Owner FUKANGREN BIO PHARMA
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