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Compound medicinal preparation with clopidogrel and red rice extracts and application thereof

A clopidogrel and extract technology, applied in the field of compound pharmaceutical compositions, can solve problems such as unsatisfactory curative effect, and achieve the effects of synergistic effect, convenient operation and simple process

Inactive Publication Date: 2006-01-18
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, in clinical practice, simple antithrombotic treatment or simple blood lipid-lowering treatment is mainly aimed at symptoms, but the curative effect is not satisfactory.
In order to solve the problems of safe, convenient and effective medication and reduce side effects, the invention provides a compound pharmaceutical composition composed of clopidogrel and red yeast extract

Method used

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  • Compound medicinal preparation with clopidogrel and red rice extracts and application thereof
  • Compound medicinal preparation with clopidogrel and red rice extracts and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation of Clopidogrel + Red Yeast Extract Tablets

[0037] Prescription: Prepare a prescription dosage of 1000 tablets

[0038] Clopidogrel 75g

[0039] Red Yeast Extract 300g

[0040] Microcrystalline Cellulose 105g

[0041] Sodium carboxymethyl starch 20g

[0042] Polyvinylpyrrolidone 8g

[0043] Micronized silica gel 4g

[0044] Magnesium Stearate 2g

[0045] Preparation method: pass the medicine and excipients through 80 mesh sieve respectively, weigh the prescription amount of red yeast rice extract, clopidogrel, bifendate, microcrystalline cellulose, sodium carboxymethyl starch (2 / 3), mix Evenly, use 10% polyvinylpyrrolidone aqueous solution to make soft material, pass through a 16 mesh sieve, dry, granulate, add the remaining (1 / 3) sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, and press into tablets to obtain ordinary tablet.

[0046] On the basis of ordinary tablets, enteric-coated tablet preparations can be pre...

Embodiment 2

[0064] Example 2: Preparation of Clopidogrel + Red Yeast Extract Dispersible Tablets

[0065] Prescription: Prepare a prescription dosage of 1000 tablets

[0066] Clopidogrel 75g

[0067] Red Yeast Extract 200g

[0068] Microcrystalline Cellulose 180g

[0069] PPVP 40g

[0070] L-HPC 9g

[0071] Aspartame 2.5g

[0072] Lemon essence 1.0g

[0073] Talc powder 4.5g

[0074] Appropriate amount of starch slurry

[0075] Preparation method: pass the medicine and auxiliary materials through 80 mesh sieves respectively, weigh the prescription amount of red yeast rice extract, clopidogrel, bifendate, mannitol, microcrystalline cellulose, mix well, add appropriate amount of starch slurry to prepare Make soft material, granulate with 16 mesh sieve, dry at 80°C for 3 hours, granulate with 16 mesh sieve, add disintegrating agent PPVP, L-HPC, flavoring agent aspartame, lemon essence, lubricant talcum powder, After mixing, compress into dispersible tablets. Example 3: Preparation ...

Embodiment 3

[0075] Preparation method: pass the medicine and auxiliary materials through 80 mesh sieves respectively, weigh the prescription amount of red yeast rice extract, clopidogrel, bifendate, mannitol, microcrystalline cellulose, mix well, add appropriate amount of starch slurry to prepare Make soft material, granulate with 16 mesh sieve, dry at 80°C for 3 hours, granulate with 16 mesh sieve, add disintegrating agent PPVP, L-HPC, flavoring agent aspartame, lemon essence, lubricant talcum powder, After mixing, compress into dispersible tablets. Example 3: Preparation of clopidogrel + red yeast extract chewable tablets

[0076] Prescription: Prepare a prescription dosage of 1000 tablets

[0077] Clopidogrel 75g

[0078] Red Yeast Extract 250g

[0079] Starch 40g

[0080] Microcrystalline Cellulose 42g

[0081] Citric acid 2.5g

[0082] Aspartame 1.5g

[0083] Talc powder 4g

[0084] 5% PVP50% alcohol solution appropriate amount

[0085] Preparation method: pass the medicine ...

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Abstract

The invention relates to a medicinal composition comprising effective dose of red yeast rice extract and at least a medicament for resisting platelet aggregation, especially compound medicinal preparation of Clopidogrel red yeast rice extract and its use, the preparation can also contain right amount of liver-protective agent, and at least one kind of pharmaceutically acceptable excipient.

Description

Technical field: [0001] The present invention relates to a compound pharmaceutical composition, in particular to a pharmaceutical composition comprising an effective amount of red yeast rice extract and at least one anti-platelet aggregation drug, and if necessary, an appropriate amount of liver-protecting drug, and at least one Pharmaceutically acceptable excipients. Background technique: [0002] As a traditional Chinese medicine, red yeast rice is recorded in "Pharmacopoeia of the People's Republic of China" and "Dictionary of Chinese Medicine". Description Red koji, also known as red koji, is prepared by inoculating Monascus on rice and fermenting it. In recent years, relevant scholars at home and abroad have continuously deepened the research on red yeast rice, and found that the active ingredients in red yeast rice mainly include: cholesterol synthesis inhibitor (lovastatin), unsaturated fatty acids, alcohols and ester compounds, various Pigments, hypotensive substan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K45/06A61K9/48A61P3/06
Inventor 王进京严轶东张惠芳
Owner FUKANGREN BIO PHARMA
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