59results about How to "Fast release rate" patented technology

A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and / or elevated relative humidity.

The invention relates to a hierarchical pore zeolite molecular sieve and a preparation method, which belongs to the fine chemical and inorganic material field. The invention relates to a ZSM-12 zeolite molecular sieve having intergranular mesoporous and macroporous and a preparation method, the invention is characterized in that a traditional template tetraethyl ammonium bromide TEABr or a tetraethyl ammonium hydroxide TEAOH synthesized by zeolite are taken as a template to synthesize the hierarchical pore zeolite molecular sieve, the problem that the synthesis of the hierarchical pore zeolite molecular sieve employs post-treatment or expensive hard template to prepare the mesoporous can be solved, according to the material, the diffusion path is substantially shortened and the acid site accessibility is enhanced, and the material has important utility value on fine chemical, catalysis of petroleum chemical, adsorption and separating.

The invention discloses a silymarin nano-crystal self-stabilizing Pickering emulsion and a preparation method thereof. The emulsion is an oil-in-water type Pickering emulsion consisting of silymarin nano-crystal, an oil phase and water. According to the preparation method of the Pickering emulsion, nano-crystal is prepared from silymarin by utilizing a high pressure homogenization method, so that silymarin nano-crystal is adsorbed to the surface of an oil drop, the oil drop is coated with a medicine, the medicine is partially dissolved in the oil phase and partially adsorbed to the surface of the oil drop in a nano-crystal mode, and the oil drop can be stably distributed in water to form a stable emulsion; the medicine in the emulsion is an effective component, and can play a role in stabilizing the emulsion. The emulsion prepared by the method does not contain a surfactant or an organic solvent, and has stability, quick release speed and excellent bioavailability.

This disclosure features a system for processing microspheres. A vessel contains a suspension of solidified microspheres comprising polymer and an active agent. A hydrocyclone has a fluid inlet, a first fluid outlet and a second fluid outlet. The fluid inlet is in fluid communication with the vessel and receives the suspension. The second fluid outlet contains a flow of the suspension having concentrated microspheres. The first fluid outlet contains a flow of a relatively large amount of liquid compared to the flow from the second fluid outlet. Also featured is a method of processing the microspheres using the hydrocyclone.

The invention discloses a radiating heating furnace with an annular flue. The radiating heating furnace comprises a furnace body, an air supply channel with an air inlet is arranged on the upper portion of the furnace body, a plurality of primary air inlet holes are formed in the bottom of the air supply channel, a plurality of secondary air inlet holes are formed in the inner wall of the air supply channel, a primary air inlet channel is formed between the outer wall of a hearth and the inner wall of the furnace body, the primary air inlet holes are communicated with the bottom of the hearth through the primary air inlet channel, the secondary air inlet holes are directly communicated with the hearth, the annular flue is arranged on the upper portion of the air supply channel, the flue is communicated with the hearth through a smoke inlet, a plurality of thermoelectricity modules generating electricity through temperature difference are arranged between the flue and the air supply channel, and an air blower powered by the thermoelectricity modules is arranged on the air inlet. The radiating heating furnace with the annular flue has the good combustion and heating effects in high-altitude regions, and is suitable for being used in the high-altitude regions. According to the radiating heating furnace with the annular flue, when smoke passes through the secondary air inlet holes, unburned smoke is combusted again, the hearth and smoke temperature rises, the radiating efficiency of the annular flue is improved, the heating efficiency is high, and the using and maintenance cost is low.

The invention belongs to the pharmaceutical technical field, relates to a solid pharmaceutical composition of an EGFR inhibitor, and in particular, relates to a solid pharmaceutical composition prepared with a compound represented by the formula (I) or a pharmaceutically acceptable salt as raw material and a preparation method thereof. On one hand, the solid pharmaceutical composition includes a diluent, a disintegrating agent and a lubricant; on the other hand, a carrier material is selected from a solid dispersion body of a cellulose compound. The solid pharmaceutical composition obviously improves the water solubility and stability of the compound, has faster release rate, and helps to improve the bioavailability.

The invention provides a pH sensitive bacillus subtilis fungicide. The fungicide comprises bacillus subtilis and / or spore, dopamine or salt thereof and pH sensitive polymer macromolecules. The dopamine is attached to the surface of the bacillus subtilis, and the surface of the dopamine is coated with the pH sensitive polymer molecules, so that the pH sensitive bacillus subtilis fungicide capable of adjusting the release amount of live bacteria wrapped therein according to the pH vale of the environment can be prepared. In the salinization soil, by applying the pH sensitive bacillus subtilis fungicide provided in the invention, the live bacteria can be rapidly released, so that the soil salinization problem of the soil can be rapidly improved; and by applying the pH sensitive bacillus subtilis fungicide provide in the acidified soil, the release rate of the live bacteria in the fungicide can be effectively retarded, the loss of organic fertilizer generated by the decomposition of live bacteria in the acid soil can be prevented, and the utilization efficiency of the fertilizer can be improved.

The invention provides slow-controlled release fertilizer. The slow-controlled release fertilizer includes a fertilizer core, a binder and an outer coating film, wherein the fertilizer core includes chemical fertilizer and bentonite, the binder includes a polyvinyl alcohol solution, and the outer coating film also includes magnesium ammonium phosphate, super absorbent resin and rooting powder. Theraw materials of the slow-controlled release fertilizer comprise, in parts by mass, 50-85 parts of the chemical fertilizer, 5-10 parts of bentonite, 10-15 parts of the binder, 15-25 parts of magnesium ammonium phosphate, 10-20 parts of the super absorbent resin and 1-3 parts of the rooting powder, and the chemical fertilizer includes nitrogen fertilizer, potassium fertilizer and phosphorus fertilizer at a mass ratio of (25-38):(12-20):(15-24). The slow-controlled release fertilizer has a good slow-release effect.

The invention discloses an essential oil nano emulsion emulsified by xanthan gum. The essential oil nano emulsion mainly consists of the following components in percentage by volume: 1 to 20 percent of composite oil phase taking clove essential oil as a main component; 60 to 78 percent of a xanthan gum solution; and 15 to 23 percent of a starch octenyl succinate solution. The invention also provides a preparation method and application of the essential oil nano emulsion emulsified by xanthan gum. The nano emulsion can play a role in preserving fresh-cut fruits and vegetables, and particularlycan solve the problems of easy rot and browning of fresh-cut apples in the prior art.

The invention belongs to the technical field of oral cavity health care, and particularly relates to a chewable composition (such as chewing gums) containing phosphosilicate glass and a preparation method of the chewable composition. The chewable composition containing phosphosilicate glass and a chewable substance are prepared, wherein after the phosphosilicate glass is in contact with oral cavity saliva, a series of chemical reactions can occur, and finally, the repairing effects of the phosphosilicate glass on the surfaces of teeth or gums can be exerted. In addition, the phosphosilicate glass in the chewable composition and the chewable substance has high dissolving-out properties and stable pH value, so that various gene expression can be promoted, and the purpose of preventing and treating oral cavity problems of oral cavity infection, oral cavity ulcer, gingivitis and the like can be achieved; and besides, through remineralization of the chewable composition on teeth, hemodia can be relieved. The preparation method disclosed by the invention is simple in technology, the raw materials are cheap and easy to obtain, and the chewable composition is suitable for industrialized mass production.

The invention relates to the field of pharmaceutic preparations, in particular to a ginkgolide K preparation and a preparation method thereof. A ginkgolide K hot-melt extruded capsule is prepared fromthe following components in parts by mass: 7.5 to 15 parts of ginkgolide K, 30 to 75 parts of a hydrophilic macromolecular carrier, 5 to 40 parts of a solubilizer and a stabilizer and 2 to 15 parts of a plasticizer. The invention further discloses a preparation method of the ginkgolide K hot-melt extruded capsule. According to the preparation method, the ginkgolide K is prepared into the hot-meltextruded capsule, so that the dissolubility of the ginkgolide K is improved, and the biological utilization degree of oral administration can be increased; the ginkgolide K preparation has the characteristics of small use amount, high product stability, increase of the drug use compliance of a patient and the like.

The invention relates to the field of pharmaceutical preparations, in particular to a rivaroxaban tablet and a preparation method thereof. According to the rivaroxaban tablet, a co-treatment substance formed by mannitol and other pharmaceutically acceptable auxiliary materials is mixed with rivaroxaban, and the mixture can be directly tableted to form a tablet, especially in a rivaroxaban micronized raw material; and by adoption of the composition provided by the invention, the problem of uneven dispersion caused by easy agglomeration of the raw material during tabletting of the conventional rivaroxaban micronized raw material can be solved. The process for preparing the tablet from the composition is few in steps, the required equipment is simple, the manpower and fixed asset cost for preparing the rivaroxaban tablet can be greatly reduced, and meanwhile after the composition is tableted, the rivaroxaban content uniformity is better, the release rate is high, and the release degree is more stable.

The invention relates to a pharmaceutical composition containing idebenone and a preparation method thereof, in particular to a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and idebenone that can improve cognitive behavior A pharmaceutical composition of benzoquinone and a preparation method thereof belong to the technical field of pharmaceutical preparations. The pharmaceutical composition comprises idebenone, a stabilizer and a freeze-drying protective agent, wherein the percentage composition of each component in the composition is as follows: idebenone accounts for 20-50%, and stabilizer accounts for 2-50%. 10%, freeze-drying protective agent accounts for 40-60%, and the weight ratio of idebenone to stabilizer is 15:1-3:1. The present invention uses freeze-drying technology to freeze-dry the prepared pharmaceutical composition suspension to obtain a powdered pharmaceutical composition, and the freeze-dried powder of the pharmaceutical composition can be rapidly dispersed into Nanosuspension state.

The invention provides a curcumin carrier with temperature response. A lyotropic liquid crystal (hexagonal phase and three-dimensional phase) is built in a water medium with non-ionic surfactants (Brij97 and Tween40) and oleic acid to serve as a drug carrier of curcumin. When the temperature of the drug carrier provided by the application rises, the releasing rate of a sample increases, and the highest releasing rate is reached when the temperature of the drug carrier is approximate to the temperature of human body. The drug carrier can be released rapidly after being taken, and facilitates rapid treatment of diseases with drug. Moreover, the carrier has a better slow-releasing effect on the curcumin, and can reduce the taking times of the curcumin.

The invention provides a famciclovir sustained-release pellet, a preparation method and an application thereof. The famciclovir sustained-release pellet provided by the invention is composed of a blank pellet core used as a core, a main drug layer containing famciclovir and coating the pellet core, and a sustained-release coating layer coating the main drug layer; the weight of polymer contained in the sustained-release coating layer is 8-15% of the total weight of the blank pellet core and the main drug layer. The famciclovir sustained-release pellet is prepared by a spraying method. According to the famciclovir sustained-release pellet provided by the invention, not only the high drug release rate of the famciclovir sustained-release pellet in an acidic medium is significantly inhibited, but also the final complete release is not influenced; and the following release degree scopes can be realized: 10-30% (1.5 hours), 30-70% (3 hours), and not less than 90% (8 hours).