The invention is applicable to the technical field of
pharmacy and provides an enteric-soluble
duloxetine hydrochloride controlled-release tablet. The
duloxetine hydrochloride controlled-release tablet comprises a tablet core and a
semipermeable membrane coated on the outer surface of the tablet core, wherein the tablet core comprises a
drug-containing layer and a boosting layer which are adjacently arranged; a diaphragm is arranged between the
drug-containing layer and the boosting layer; a through hole is formed in the
semipermeable membrane; an enteric-soluble membrane is coated on the outer surface of the
semipermeable membrane; the
drug-containing layer comprises substances such as
duloxetine hydrochloride, and the like. By compounding and adopting a double-layer
osmotic pump and the enteric-soluble, medicines in the drug-containing layer are pushed to release from the through hole at a
constant speed (namely zero-level release) by utilizing the stable swelling effect after the boosting layer absorbs water, so that the
controlled release purpose is achieved; moreover, the enteric-soluble membrane is coated on the outer surface of the semipermeable membrane, so that intestinal tract
controlled release of the acid-sensitive type
duloxetine hydrochloride is realized. The preparation method of the
duloxetine hydrochloride controlled-release tablet is simple in process, easy to operate and very suitable for industrial production.