54results about How to "To achieve the purpose of controlled release" patented technology

The invention provides a method for preparing a collagen-modified bacteria cellulose compound film, which relates to relevant fields of biomedical medical materials, medical appliances and cosmetics. The preparation method comprises the following steps of: pretreating and purifying a bacteria cellulose film to obtain purified bacteria cellulose, and functionalizing the hydroxyl of the purified bacteria cellulose; and physically compounding or chemically combining the bacteria cellulose film and a collagen suspension to obtain a collagen-modified bacteria cellulose compound film. Due to the adoption of the collagen-modified bacteria cellulose compound film obtained with the method, the recovery of collagen content in defect tissues can be promoted, the problems of poor water permeability, poor air permeability, poor drainage and poor absorbing effect existing in the conventional collagen medicament are solved simultaneously; a novel method for collagen application is provided, high cell affinity is achieved, and the tissue growth is facilitated. The method has a simple preparation process and a mature process, and is suitable for industrial production of collagen-modified bacteria cellulose compound films with different requirements.

The synthesis process of urea-formaldehyde controlled releasing fertilizer includes mixing gelatinized starch and urea, adding the mixture of polymer water absorbing resin and formaldehyde solution, adding vegetable oil, organic matter including turf and stalk and adsorbent including zeolite, adding sulfuric acid for acidifying to obtain solid product, and final drying, crushing and sieving to obtain the product. The said process avoids excessive crosslinking of polymer to raise the utility of nitrogen, avoids volatizing of formaldehyde during reaction to raise environment quality and production efficiency, and adds zeolite and other inorganic stuffing to raise product quality and provide water maintaining and fertilizer maintaining function and trace elements. In addition, phosphate fertilizer and potash fertilizer may be also added to produce re-compounded fertilizer.

The invention discloses a unidirectional flap. The unidirectional flap comprises a framework and an isolation membrane, wherein the framework comprises a far end, a near end and at least three vertical beams which are arranged between the near end and the far end; membrane-coating loca are arranged on the surfaces of the vertical beams; convex points are arranged on the membrane-coating loca and used for increasing friction force between the unidirectional flap and a bronchial tube; at least one isolation membrane penetrates through the membrane-coating loca to be covered on the surface of the far end; a mesh is arranged at the far end; and the near end is a closed structure which is composed of 2-3 sealed, mutually-separated and flap-shaped structures. According to the unidirectional flap, due to the adoption of the closed framework structure, support force and stability of the framework are improved; and quoin points, contacted with the inner wall of the bronchial tube, of the framework are reduced; damage rate of the inner wall of the bronchial tube caused due to machines is reduced; and occurrence probability of bronchitis is reduced.

Conjugate linoleate microcapsule consists of conjugate linoleate, other aliphatic salt, wall material, solvent and antioxidant. Mixed aliphatic salt powder containing conjugate linoleate is suspended on fluidized bed, wall material is dissolved in solvent and sprayed into the fluidized bed, and the microcapsule product is obtained through drying. Great amount of experiment shows that the product has high antioxidant stability and long shelf life, is easy to use, and may be controlled to release and to mask bad smell.

The invention discloses a preparation method for nano-sized zirconium-based cation metal organic framework (Zr-MOFs) materials carrying an anionic medicine. According to the method, firstly, cation functionalized Zr-MOFs are obtained, then, the anionic medicine is loaded to the Zr-MOFs, and the releasing effect of the Zr-MOFs is controlled through pH. After an n-donor ligand of the synthesized Zr-MOFs materials is subjected to cationization, due to the coulomb force, very strong acting force is exerted to the anionic medicine, a large loading capacity can be reached, and the nano-sized Zr-MOFs materials carrying the anionic medicine have a pH controlled-release effect in the medicine slow-release process. Thus, the materials have potential application prospects in the aspects of anionic medicine loading and controlled releasing.

The invention discloses an organic enveloped controlled-release compound fertilizer. The fertilizer comprises the following raw materials in parts by weight: 30-60 parts of urea, 10-30 parts of monoammonium phosphate, 10-36 parts of potassium salt, 10 parts of active organic matter and 0.02-0.1 part of trace elements. The organic enveloped controlled-release compound fertilizer has the advantagesof improving the quality of soil so that plants can more efficiently utilize the fertilizer, promoting the metabolization of various nutrient elements, improving the quality of agricultural products,increasing yield, reducing farmland investment cost, lightening labor intensity, increasing roots and strengthening seedlings, promoting growth of plants and enhancing stress resistance, and has quick-acting and long-acting dual effects.

The invention relates to the technical field of plant plantation, and specifically relates to a method for planting Syzygium samarangense. The method comprises: (1) selecting land and preparing land; (2) planting; (3) performing field management: a, regulating in a production period, b, forcing flowers, c, blossom and fruit thinning, d, bagging; (4) harvesting fruits: when 70-90% of Syzygium samarangense areola is unfolded and variety inherent color appears, harvesting. The invention provides the method for planting Syzygium samarangense, and provides a technical scheme for Syzygium samarangense standardized planting, and meanwhile using production period regulation, the Syzygium samarangense come into the market staggering a selling season of July to August. The method improves quality of Syzygium samarangens, and improves economical benefits of Syzygium samarangens planting.

The invention relates to a slow release type chlorine dioxide solid disinfectant and a preparation method thereof. The slow release type chlorine dioxide solid disinfectant is composed of a component A, a component B and a double-layer slow release device. The component A comprises chlorine dioxide parent, a reducing agent, a filling agent, a stabilizer and a slow release carrier. The component B comprises acid solution. The component A is placed in the double-layer slow release device, and the component B is independently packaged. The preparation method is simple, and the slow release type chlorine dioxide solid disinfectant is suitable for industrial large-scale production, convenient to use, easy to store and long in guarantee period and has good application prospects in the fields such as home furnishing, environmental protection and health defence. The slow release type chlorine dioxide solid disinfectant can be used for deodorization and disinfection of a refrigerator, a toilet, a shoe cabinet, a storage room and the inside of a vehicle and the like.

The invention discloses a pear tree planting controlled-release fertilizer which is prepared from the following raw materials in parts by weight: 30-35 parts of seaweed meal, 25-30 parts of bean pulp, 20-24 parts of tobacco powder, 25-28 parts of ash wood, 50-70 parts of rice straws, 65-80 parts of maize straws, 2-3 parts of EM biological agent, 12-14 parts of quartz stone powder, 8-12 parts of urea, 8-10 parts of biammonium carbonate, 6-7 parts of potassium nitrate, 7-8 parts of phosphate fertilizer, 4-5 parts of calcium chloride, 7-9 parts of borax, 8-12 parts of alkyd resin, 2-3 parts of propyl alcohol, 3-4 parts of sodium dodecyl benzene sulfonate, 5-6 parts of cross-linking agent and a proper amount of water. According to the controlled-release fertilizer disclosed by the invention, organic wastes serve as basic raw materials, nitrogen is particularly added to meet the special requirement of pear trees on the nitrogen fertilizer, the chemical components and resins are combined by utilizing solidification of the resins and cross-linking agents, and finally resin granules are prepared to be mixed in organic matters, so that the concentration change degradation rate of the cross-linking agents and resins can be controlled, the controlled release aim is achieved, and the fertilization frequency is reduced.

The invention relates to a preparation method and application of a combined targeted medicine controlled release system with a gold nanometer cage being a carrier. The problem that existing tumor treating medicine is large in side effect and poor in treating effect and the medication problem about photothermal therapy of tumors are effectively solved. The method includes the steps that, Re2O3, Fe(NO3)3, Mn(NO3)2, zinc(NO3)2, citric acid, ethylene glycol and the gold nanoparticle cage are added into HNO3, the pH is adjusted to 6, centrifuging is performed, sediment is redissolved through water, the pH is adjusted to 6, drying is performed, and the gold nanometer cage coated with manganese-zinc ferrite is obtained; thermosensitive materials are heated, medicine and the gold nanometer cage coated with the manganese-zinc ferrite are added in, centrifuging is performed, and gold nanometer cage-manganese-zinc ferrite compounds carrying the manganese-zinc ferrite and the thermosensitive materials are obtained; OPSS-PEG-SVA is added into a PBS buffering solution with -NH2 group target head molecules, the gold nanometer cage-manganese-zinc ferrite compounds are added in, centrifuging is performed, sediment is washed through the PBS buffering solution, and the combined targeted medicine controlled release system with the gold nanometer cage being the carrier is obtained. By means of the preparation method and the application, the purposes of thermal therapy, chemical (gene) treatment, targeting and controlled release can be achieved at the same time.

According to the invention, high-fiber organic materials such as sawdust, waste paper and humus are adopted as basic materials and fermented to be used as a base fertilizer so as to improve soil for a root system of towel gourd, the towel gourd belongs to a vegetable planted in hole soil, and the soil quality and nutrients near the root system play an important role in the quality and yield of towel gourd; fermented sawdust, humus and leaves have thermal-insulation effects, so that the survival of towel gourd seedlings is facilitated, the towel gourd seedlings are protected from the frost damage caused by cold spell in spring, and survival rates of the seedlings is improved; and meanwhile, nitrogen, phosphorus and potassium components are added by virtue of coating in resin, nutrients are slowly released during the degradation process of the resin, and the degradation speed of the resin can be controlled and regulated by changing concentrations of the resin and the crosslinking agent so as to achieve the purpose of controlled release, which is very important in subsequent fertilizer and water management.

The invention relates to a preparation method of a medicine sustained-release system with pH and near-infrared light dual response. The preparation method comprises the following steps of preparing graphene oxide, preparing graphene oxide / aminated mesoporous silica, preparing methotrexate / graphene oxide / aminated mesoporous silica, and preparing a methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system. The preparation method provided by the invention has the beneficial effects that amino groups on the surface of aminated mesoporous silica and carboxyl onsodium alginate take amidation reaction, so that amido bonds can be generated to coat the surface of the mesoporous silica with the sodium alginate, and a sealing and blocking effect is achieved on medicine methotrexate in mesopores. The amido bonds have certain pH sensitivity, and the graphene oxide has good light-to-heat conversion characteristics, so that the methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system with pH and near-infrared light dual response is obtained. The methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system can achieve the goal of controlled release of medicine through dual stimulation of near-infrared light and pH.

The invention discloses a polymer composite microsphere as well as a preparation method and application thereof. The polymer composite microsphere comprises a microsphere matrix, and the preparation raw materials of the microsphere matrix comprise a hydrophobic degradable polymer; the drug particles are dispersed in the microsphere matrix, and each drug particle comprises a hydrophobic drug inner core and a water-soluble polymer layer wrapping the surface of the hydrophobic drug inner core; the surface of the microsphere matrix is coated with the coating film, and preparation raw materials of the coating film comprise natural macromolecules. According to the high-molecular composite microsphere disclosed by the invention, the loading capacity, the release capacity and the controlled release effect of the high-molecular composite microsphere on hydrophobic drugs can be effectively improved through regulation and control of components.

The invention provides a phosphate fertilizer controllably released through a pH-sensitive material. The phosphate fertilizer is characterized by being prepared by coating a water-soluble phosphate fertilizer with the pH-sensitive material, wherein the pH-sensitive material is prepared by crosslinking wheat gluten and zeolite under the action of a crosslinking agent; after a crop is lack of phosphorus, the pH value of the periphery of the root system is reduced because organic acid secreted by the root system of the crop is increased, and the wheat gluten embedded in pores of the zeolite is pored through soluble inflation and hydrolysis under the condition of low pH value, so that a controlled release effect is achieved; and at the moment, water-soluble phosphorus cannot be fixed by soil due to the existence of organic acid, so that the efficient absorption of the crop on phosphorus is increased to the maximum extent, and the fixed and lost phosphorus is reduced. By using the phosphate fertilizer controllably released through the pH-sensitive material, the problems that the absorption and utilization rates of crops on phosphorus are low and phosphorus is easily fixed and lost because phosphorus in the existing controlled-release phosphate fertilizer cannot be controllably released according to the growth demands of the crops are solved.

An environment-friendly graphene-based aqueous antifouling paint adopts a two-component design, wherein a component A is composed of a water-based resin emulsion, an antifouling agent / graphene compound, zinc oxide, rosin, a filler, an auxiliary agent and the like, and a component B is a water-based polyamine curing agent; the component A and the component B are blended according to a certain proportion during construction. The antifouling paint has excellent antifouling performance, and the antifouling agent is loaded on the surface of the graphene through chemical bonding, so that the purposeof controlled release of the antifouling agent is achieved. The aqueous antifouling paint has antifouling validity period of 12 months on Xiamen sea area shallow sea hanging plate, has the antifouling validity period of 1-2 years in the actual application process, and has wide application prospects.

The invention discloses ultrasonic activateable medicine-release albumin nanoparticles as well as a preparation method and application thereof. The ultrasonic activateable medicine-release albumin nanoparticles adopt azo-group-containing small molecules as a chemical cross-linking agent and albumin as a nanoparticle framework, coats an anti-cancer medicine and is prepared by using a solvent removing method; and the nanoparticles have particle sizes of 50-300nm under normal physiological conditions, and are uniform and stable in distribution. Under the action of ultrasonic waves acceptable by aliving body, the azo bond of the cross-linking agent can be broken, then the structure of the albumin nanoparticles can be damaged, medicines coated by the albumin nanoparticles can be rapidly released, the release amount of the medicines can be regulated and controlled through ultrasonic time and intensities, and the maximum release amount is up to 70%. Through intensive permeability of the ultrasonic waves, the albumin nanoparticles are capable of achieving rapid and controlled release of medicines at tumor tissue.

The invention relates to a mineral filter material, which is characterized by comprising a mineralization material and an embedding material coated on the periphery of the mineralization material. Theembedding material is at least one of zeolite, calcium carbonate and magnesium carbonate. The invention also discloses a preparation method of the mineral filter material, a filter element with the mineral filter material and a water quality mineralization method of the filter element. In the dissolving process of the embedding material, the mineralizing material can be gradually exposed, so thatthe purpose of slowly releasing mineral substances is achieved. Meanwhile, the mineralizing material is combined with the micro-nano bubbles, so that the mineralizing efficiency of the raw water is improved. The embedding material and carbon dioxide can generate chemical reaction, so that the dissolution rate is increased.

The invention discloses a method for preparing a compound controlled-release capsule for treating benign hyperplasia of prostate and the compound controlled-release capsule for treating the benign hyperplasia of prostate, and belongs to the technical field of medicines. The method comprises that: common micro pills containing the finasteride medicine and slow release micro pills containing the doxazosin pills are prepared respectively, and the two kinds of micro pills are mixed and encapsulated to prepare the controlled-release capsule, wherein the mass ratio of the finasteride medicine to the doxazosin medicine in the capsule is 1:0.625-2.5. In the method, ethylcellulose and hydroxypropyl emthylcellulose are used as auxiliary materials of the slow release preparation, and by combining the preparation process by which the auxiliary materials is mutually cooperated with compound medicines, the finasteride-doxazosin compound controlled-release capsule is prepared. Active ingredients in the two medicines in the preparation not only can be mutually cooperated to achieve better curative effects, but also can stably release the medicines, avoid the difference between blood concentration at wave crest and wave hollow, and reduce toxic and side effects of the medicines on human body; moreover, the controlled-release capsule can also shorten the medicine taking time of patients and improve compliance of taking medicines. The finasteride-doxazosin controlled-release capsule can be used as the medicine to treat hypertension and benign hyperplasia of prostate.

The invention discloses a preparation method and application of PAMs (natural plant antimicrobial solution) hydrogel patch. The hydrogel patch is prepared from 15-45 parts by weight of glycerol, 2-6 parts by weight of NP-700, 0.2-0.6 parts by weight of dihydroxyaluminium aminoacetate, 13.6-40.7 parts by weight of distilled water, 0.1-0.3 parts by weight of tartaric acid, 1.5-4.5 parts by weight ofazone, 1.5-4.5 parts by weight of propylene glycol, 0.25-0.75 parts by weight of SDS (sodium dodecyl sulfate), and 15.85-47.55 parts by weight of PAMs. The hydrogel patch provided by the invention has the beneficial effects of good moldability, viscoelasticity, gas permeability, good peeling property from skin and good therapeutic effect on skin burns, and can prevent skin ulceration, and has good antimicrobial and anti-inflammatory effects on wounds and good repairing effects on wound surface to slow down the problem of scar residue. The hydrogel patch is obtained by one-time heat preservation crosslinking, and the operation is convenient and advantageous for large-scale production.

The invention provides a method for preparing a collagen-modified bacteria cellulose compound film, which relates to relevant fields of biomedical medical materials, medical appliances and cosmetics. The preparation method comprises the following steps of: pretreating and purifying a bacteria cellulose film to obtain purified bacteria cellulose, and functionalizing the hydroxyl of the purified bacteria cellulose; and physically compounding or chemically combining the bacteria cellulose film and a collagen suspension to obtain a collagen-modified bacteria cellulose compound film. Due to the adoption of the collagen-modified bacteria cellulose compound film obtained with the method, the recovery of collagen content in defect tissues can be promoted, the problems of poor water permeability, poor air permeability, poor drainage and poor absorbing effect existing in the conventional collagen medicament are solved simultaneously; a novel method for collagen application is provided, high cell affinity is achieved, and the tissue growth is facilitated. The method has a simple preparation process and a mature process, and is suitable for industrial production of collagen-modified bacteria cellulose compound films with different requirements.

The invention discloses a planting method for a garden plant. The planting method for a garden plant comprises the following steps: (1) loosening soil, spreading an organic fertilizer on the soil, then spreading a layer of dry straws and plant ash above the organic fertilizer, and fermenting for 5-7 days; (2) spraying wheat bran, water and brown sugar onto the soil treated in the step (1), loosening the soil to sufficiently mix the dry straws, plant ash, wheat bran, water and brown sugar, and fermenting for 10-12 days; and (3) digging a hole, putting a garden plant seedling into the hole, and performing filling and tamping treatment to achieve an effect of increasing the survival rate.

The invention discloses a methotrexate transdermal drug delivery local controlled release preparation and a preparation method and application thereof. The preparation is obtained through the steps that mesoporous silica is loaded with methotrexate, the surface is wrapped with a layer of polydopamine or polymethyldopa. The adopted mesoporous silica is good in biocompatibility, large in specific surface area and high in drug loading capacity, and is polymerized through polydopamine under alkaline conditions, and methotrexate is degraded and released under acidic conditions, and controlled drugrelease is achieved. The outer surface of a drug is wrapped with a layer of black polydopamine, the photostability of the methotrexate can be ensured, and better convenience is brought to the processof drug preservation and management. Meanwhile, it is found through research that polymethyldopa shows the similar gating effect as that of the polydopamine, and intelligent drug delivery is achieved.

The invention discloses a medium-sized hedge plant planting method. The medium-sized hedge plant planting method includes the following steps: (1) evenly dispersing a fertilizer and an adhesive in water to acquire an inner core, spraying an outer surface of the inner core with a micro-permeable layer, and acquiring fertilizer particles; (2) taking hollow L-shaped degradable tubes, forming a plurality of through holes in bottom surfaces of cross tubes of the degradable tubes, and putting the acquired fertilizer particles of the step (1) in the cross tubes; (3) digging holes in a soil layer, putting a plurality of degradable tubes of the step (2) in the holes, wherein the cross tubes of the degradable tubes are paved on the bottoms of the holes, the through holes contact the bottoms of the holes, and vertical tubes of the degradable tubes extend outward to an outer environment; and (4) putting soil into the holes of the step (3), putting young seedlings of the medium-sized hedge plant above the soil, and performing burying and compacting. The effect of reducing the frequency of fertilizing can be achieved.

The invention discloses a controllable release halloysite loaded molybdate corrosion inhibitor and a preparation method of the controllable release halloysite loaded molybdate corrosion inhibitor. Themethod comprises the steps that molybdate is loaded into HNTs by a negative pressure method according to the nano container effect of HNTs, and an insoluble CaMoO4 complex is formed in a port of theHNTs through mutual interaction of Ca ions and MoO42- of a pipe orifice slow down the release speed of MoO42- in a pipe. Therefore, the service life of the corrosion inhibitor is prolonged through thecontrolled release behavior of the corrosion inhibitor, so that the corrosion inhibitor can be conveniently and effectively used for corrosion prevention of metal materials, and the effect of releasing the corrosion inhibitor for a long time is achieved.

The synthesis process of urea-formaldehyde controlled releasing fertilizer includes mixing gelatinized starch and urea, adding the mixture of polymer water absorbing resin and formaldehyde solution, adding vegetable oil, organic matter including turf and stalk and adsorbent including zeolite, adding sulfuric acid for acidifying to obtain solid product, and final drying, crushing and sieving to obtain the product. The said process avoids excessive crosslinking of polymer to raise the utility of nitrogen, avoids volatizing of formaldehyde during reaction to raise environment quality and production efficiency, and adds zeolite and other inorganic stuffing to raise product quality and provide water maintaining and fertilizer maintaining function and trace elements. In addition, phosphate fertilizer and potash fertilizer may be also added to produce re-compounded fertilizer.

The invention is applicable to the technical field of pharmacy and provides an enteric-soluble duloxetine hydrochloride controlled-release tablet. The duloxetine hydrochloride controlled-release tablet comprises a tablet core and a semipermeable membrane coated on the outer surface of the tablet core, wherein the tablet core comprises a drug-containing layer and a boosting layer which are adjacently arranged; a diaphragm is arranged between the drug-containing layer and the boosting layer; a through hole is formed in the semipermeable membrane; an enteric-soluble membrane is coated on the outer surface of the semipermeable membrane; the drug-containing layer comprises substances such as duloxetine hydrochloride, and the like. By compounding and adopting a double-layer osmotic pump and the enteric-soluble, medicines in the drug-containing layer are pushed to release from the through hole at a constant speed (namely zero-level release) by utilizing the stable swelling effect after the boosting layer absorbs water, so that the controlled release purpose is achieved; moreover, the enteric-soluble membrane is coated on the outer surface of the semipermeable membrane, so that intestinal tract controlled release of the acid-sensitive type duloxetine hydrochloride is realized. The preparation method of the duloxetine hydrochloride controlled-release tablet is simple in process, easy to operate and very suitable for industrial production.

The invention provides procaine hydrochloride micro-capsules. The procaine hydrochloride micro-capsules are prepared from procaine hydrochloride powder and a capsule material coating the procaine hydrochloride powder, wherein the mass ratio of the procaine hydrochloride powder to the capsule material is 1 to 1-6, and the capsule material is a cellulose derivative, acrylic resin RL100, gelatin, arabic gum or alginate. The invention further provides a preparation method of the procaine hydrochloride micro-capsules. The procaine hydrochloride micro-capsules can improve the stability of procaine hydrochloride, reduce side effects, reduce various adverse drug reactions and improve the medication compliance of patients.

Conjugate linoleate microcapsule consists of conjugate linoleate, other aliphatic salt, wall material, solvent and antioxidant. Mixed aliphatic salt powder containing conjugate linoleate is suspended on fluidized bed, wall material is dissolved in solvent and sprayed into the fluidized bed, and the microcapsule product is obtained through drying. Great amount of experiment shows that the product has high antioxidant stability and long shelf life, is easy to use, and may be controlled to release and to mask bad smell.

The invention relates to conjugated linoleic acid and docosahexenoic acid microencapsulated powder. The conjugated linoleic acid and docosahexenoic acid microencapsulated powder comprises a wall material, a capsule core, auxiliary agents, an emulsifying agent or a surfactant, wherein two greases of conjugated linoleic acid and docosahexenoic acid are co-used as the capsule core. A microencapsulated product is obtained by adding the capsule core into the wall material in a solution state, adding the auxiliary agents, the emulsifying agent or the surfactant to carry out emulsification, and spray drying. The conjugated linoleic acid and docosahexenoic acid microencapsulated powder can be used as a health-care food, a nutritional food capable of being taken by direct brewing, a food additive or a nutrient supplement, and has a plurality of functions.

The invention relates to a non-viral gene drug carrier of a complexing platinum-based anti-tumor drug, which is the Pt-PEI-PEG or PEG-PEI-Pt complex carrier, PEI is taken as a framework to connect polyethylene glycol and complex the platinum anti-tumor drug for constitution; and the molar percentage of all the components of the complex are: Pt: 48.8 to 83.2 percent, PEI: 16.5 to 49.8 percent, PEG: 0.17 to 2.44 percent respectively. The preparation method is that the platinum compound and the PEI are carried out the coordination, the reaction with the PEG is further carried out, thus generating the Pt-PEI-PEG complex carrier; or the platinum compound and the PEG-PEI complex are carried out the coordination reaction, thus generating the PEG-PEI-Pt complex carrier. The non-viral gene drug carrier has the advantages of effects of the anti-tumor drug, high stability, good water solubility, long cycle in vivo and lowering toxicity.