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Preparation method of medicine sustained-release system with pH and near-infrared light dual response

A near-infrared light, dual-response technology, applied in the field of material synthesis and biomedicine, can solve problems such as premature drug release and burst release

Inactive Publication Date: 2020-06-02
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although mesoporous silica has been used in the field of drug sustained release, there are still some disadvantages, such as premature release or burst release of drugs.

Method used

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  • Preparation method of medicine sustained-release system with pH and near-infrared light dual response
  • Preparation method of medicine sustained-release system with pH and near-infrared light dual response
  • Preparation method of medicine sustained-release system with pH and near-infrared light dual response

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Embodiment 1

[0027] A method for preparing a drug slow-release system with dual responses to pH and near-infrared light, comprising the following steps:

[0028] (1) Accurately weigh 6g of potassium permanganate and 1.0g of graphite powder, slowly add them to a mixed solution of 120mL of concentrated sulfuric acid and 13.3mL of phosphoric acid, heat and stir in a water bath at 50°C for 12 hours, then cool to room temperature, pour over 1mL of supernatant Stand overnight in an ice-water bath of hydrogen oxide, centrifuge and wash the product to remove the remaining acid, dry it naturally and grind it to obtain graphene oxide;

[0029] (2) Dissolve 40mg of graphene oxide in 50mL of deionized water and disperse by ultrasonic for 2h. When the graphene oxide solution turns yellow completely and no obvious solids can be seen, add 0.6g of hexadecyltrimethyl bromide ammonium chloride, stirred at 40°C for 2 h, then added 40 mg of sodium hydroxide and continued to stir for 0.5 h, then added 1.0 g of...

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Abstract

The invention relates to a preparation method of a medicine sustained-release system with pH and near-infrared light dual response. The preparation method comprises the following steps of preparing graphene oxide, preparing graphene oxide / aminated mesoporous silica, preparing methotrexate / graphene oxide / aminated mesoporous silica, and preparing a methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system. The preparation method provided by the invention has the beneficial effects that amino groups on the surface of aminated mesoporous silica and carboxyl onsodium alginate take amidation reaction, so that amido bonds can be generated to coat the surface of the mesoporous silica with the sodium alginate, and a sealing and blocking effect is achieved on medicine methotrexate in mesopores. The amido bonds have certain pH sensitivity, and the graphene oxide has good light-to-heat conversion characteristics, so that the methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system with pH and near-infrared light dual response is obtained. The methotrexate / graphene oxide / mesoporous silica / sodium alginate medicine sustained-release system can achieve the goal of controlled release of medicine through dual stimulation of near-infrared light and pH.

Description

technical field [0001] The invention relates to a preparation method of a drug slow-release system with dual responses to pH and near-infrared light, belonging to the fields of material synthesis and biomedicine. [0002] technical background [0003] Graphene oxide has attracted extensive attention from the scientific community due to its good biocompatibility, unique structural features and relatively low cost. Graphene oxide has been proven to be an efficient emerging carrier that can be used to deliver anticancer drugs, proteins, gene drugs and biological imaging agents in cells. Most importantly, graphene oxide, a photosensitive material with high near-infrared light absorption, has potential photothermal therapeutic capabilities in vitro and in vivo. Due to its large specific surface area and pore volume, tunable pore size, and easy surface functionalization, mesoporous silica is often used to construct stimuli-responsive controlled drug release systems. Although meso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/04A61K47/36A61K31/519A61P35/00
CPCA61K41/0052A61K9/5115A61K9/5161A61K9/0009A61K31/519A61P35/00A61K2300/00
Inventor 孔泳李尚基吴大同高俊秦勇陶永新
Owner CHANGZHOU UNIV
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