52results about How to "Convenient clinical diagnosis" patented technology

The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and / or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.

The invention provides an ultrasonic angiography image analysis method and system. The method comprises the following steps: obtaining a dynamic medical image meeting a DICOM (Digital Imaging and Communications in Medicine) standard; selecting an initial region of interest from the dynamic medical image; calculating a plurality of corresponding analysis parameter values of each pixel point of the initial region of interest, and carrying out colorful encoding on the analysis parameter values to obtain colorful codes of different parameters of the initial region of interest; selecting a current region of interest of the colorful codes; obtaining a parameter analysis curve of the current region of interest and a contrast speed analysis curve; providing an analysis result of the current region of interest. Compared with the prior art, the method can be used for carrying out the colorful encoding on the plurality of corresponding analysis parameter values of each pixel point, so that contrast parameters can be accurately quantified, and furthermore, accurate reference and differential diagnosis can be provided for doctors. The current region of interest can also be subjected to parameter analysis and speed analysis on the basis of the initial region of interest, and the clinical diagnosis can be facilitated.

The invention discloses a full-automatic contrast-enhanced ultrasonic image segmentation method. The method comprises the steps that step one, contrast-enhanced ultrasonic image sequences are acquired and stored, and an inter-frame grayscale standard difference matrix of multiple frames of contrast-enhanced ultrasonic image sequences is constructed; step 2, morphological filter is performed on the inter-frame grayscale standard difference matrix and then binarization is performed so that an initial contour line of an contrast-enhanced ultrasonic area is acquired; step three, an energy equation based on a Snake active contour model is constructed by utilizing the inter-frame grayscale standard difference matrix and the grayscale median matrix of continuous multiple frames of contrast-enhanced ultrasonic image sequences; and step 4, the initial contour line is substituted in the energy equation to perform multiple times of iteration so that the final contour line of the contrast-enhanced ultrasonic area is acquired, and segmentation of the contrast-enhanced ultrasonic area is realized.

The invention discloses an automatic collection device for mid-stream urine. The device comprises a collection cup body. The collection cup body comprises an upper cup cavity and a lower cup cavity, both of which communicate with each other. The upper cup cavity communicates with the lower cup cavity through an annular sleeve pipe body. The annular sleeve pipe body comprises an outer sleeve pipe and an inner sleeve pipe. A fluid passage is formed in an annular passage between the outer sleeve pipe and the inner sleeve pipe. The upper end and the lower end of the fluid passage are respectivelyequipped with an upper check ring body and a lower metal check ring body in a matching manner. The upper check ring body and the lower metal check ring are respectively equipped with multiple throughholes. Electromagnetic attraction force of the lower metal check ring is utilized to automatically and upwardly attract an annular metal check ring of a floating block body. Therefore, the annular metal check ring can be closely connected with the lower metal check ring in an attraction manner. A through hole of the lower metal check ring is blocked so that the upper cup cavity is separated from the lower cup cavity. Therefore, mid-stream urine samples can be conveniently and automatically collected. Data accuracy of urine detection is increased. Additionally, effective and stable separation is achieved.

The invention discloses a time resolution immunochromatographic test strip for detecting influenza A / B viruses and a preparation method thereof. The test strip comprises a bottom board and a sample pad, a combination pad, a reaction membrane and a water absorption pas, which are pasted on the bottom board in sequence, wherein the combination pad is coated with an influenza A / B virus monoclonal detection antibody marked by a time resolution fluorescent microsphere; the reaction membrane comprises a detection area and a quality control area parallel to and spaced from the detection area; the detection area is close to the combination pad; the quality control area is close to the water absorption pad; and the detection area and the quality control area are respectively coated with an influenza A / B viruses monoclonal capture antibody and a goat anti mouse IgG antibody for recognizing single epitopes. The time resolution immunochromatographic test strip for detecting influenza A / B viruses is high in sensitivity, simple to operate, low in cost and short in detection time, and is capable of effectively satisfying the demand of rapid clinical examination.

The invention relates to the field of medical images, in particular to a medical image digital printing method and a medical image digital printing system, which can realize the imaging of a film without a developing solution or a fixing solution. The medical image digital printing system comprises medical image scanning equipment, a printing control unit and printing equipment, wherein the medical image scanning equipment is used for performing image scanning on an object to acquire scanning data; the printing control unit is used for converting the scanning data into raster data capable of being identified by the printing equipment; and the printing equipment is used for receiving and identifying the raster data transmitted by the printing control unit and printing the raster data on the medical film.

The present invention relates to the field of biotechnology and firstly reveals that miR-19b plays an important role in osteoblast differentiation and can be used as a target for prevention and treatment of bone metabolic diseases (including osteoporosis, osteoproliferation, abnormal osteogenic differentiation, and loss of bone mass). The present application discloses the miRNA marker miR-19b associated with the bone metabolic diseases and an application thereof. An expression level of the miR-19b can distinguish between a population of the related bone metabolic diseases and a healthy population.

The invention discloses a deep learning segmentation method based on a pseudo-color CT image. The method comprises the following steps: step 1, acquiring a CT image data set SI0 and a corresponding label image data set SL0; 2, amplifying the data set through image rotation and zooming operation; 3, selecting three different interested window width window levels to obtain CT images under the corresponding window width window levels, and further generating a pseudo-color CT image data set SIP; 4, randomly dividing the pseudo-color CT image data set SIP and the corresponding label image data setSL0 into a training set ST and a test set SX; 5, constructing a deep learning network architecture; 6, training the deep learning network model by using the training set ST and the test set SX to obtain a trained segmentation model; and step 7, inputting image data needing to be detected into the trained deep learning network model to obtain a corresponding segmentation result. The CT image segmentation precision and efficiency can be effectively improved, and clinical diagnosis and treatment are facilitated.

The invention relates to an auscultation sound spectrum analysis-based multifunctional digital stethoscope circuit. A CMOS (complementary metal-oxide-semiconductor transistor) technology-based silicon microphone sensor is arranged in a stethoscope; the sensor can convert various sounds generated by organs of a human body into corresponding level signals; the level signals are subjected to operation amplification, filter anti-aliasing, and analog-to-digital conversion, and then are transmitted into an application specific integrated circuit (ASIC) for digital signal processing, wherein a digital signal processing part is characterized by comprising an FIR (finite impulse response) filter unit, a system master control unit, an FFT (fast Fourier transform) operation unit, a spectrum screening core operation unit, a data communication unit and other logic units for spectrums of different organs of the human body; through an earphone interface, a universal asynchronous receiver / transmitter(UART) or variable-gain amplifier (VGA), a doctor can listen to the sound frequency through an earphone, or performs auscultation by displaying the spectrums through the connected display, and diagnosis results can be conveniently recorded, evaluated and saved; meanwhile, by combining technology of Internet of things, digital medical treatment solutions such as remote auscultation at home, remotemultilateral consultation and establishment of a civil human organ sound frequency spectrum library are constructed.

The invention discloses an endoscope objective group with a viewing directional angle, belonging to the technical field of medical endoscope in medial apparatuses, specifically relating to an endoscope objective group and a viewing direction angle prism. In the invention, one prism in the prior art is changed into a structure formed by gluing three prisms, the original expensive optical glass ZLaF1 is changed into common K9 glass; through adjusting the optical path length of the prism, a transition block is removed, an air gap of the original design is eliminated, and the excircle shape and optical parameters of an A object lens are modified, so that the viewing angle of the object lens is designed within 5 to 90 degrees according to actual demands. The endoscope objective group comprisesprotective glass, a first object lens, an a viewing angle prism, a b viewing angle prism, a c viewing angle prism and a second object lens; a plurality of optical parts are glued into an integral round rod. The invention is convenient to be installed, thereby improving the production efficiency, reducing the cost and the environmental pollution; the aperture of the prism is increased, the observedimage information is brighter so as to facilitate the diagnosis and improve the level of the operation.