New human bio-sensors in a virtual reality headset can be worn comfortably for extended periods of time, detecting brain, nerve, ocular, muscle or other bio-signals. Recording raw data, amplification, digital conversion, filtering, support subsequent manipulation by iteratively creating multiple interpretation maps. Data processing and transmission are reduced so that control of a remote device may occur in real time, based on an event in the body of a wearer. A signal interpretation engine iteratively creates numerous interpretation maps, the best correlated one being used exclusively, thus minimizing false positives and requiring minimal data to distinguish an event from any other non-presence of that event. After training and verification, operation in real time processes live, continuous data to control a remote device based on the events detected by the sensor set in a headset, arm bands, leg bands, gloves, or boots.