36 results about "Skin photosensitivity" patented technology

Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities.

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD / AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD / AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light / temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.

The invention relates to a preparation method for graphical sapphire substrate for epitaxial growth of nitride, which comprises the following steps of: firstly, magnetron sputtering a layer of aluminous film on the sapphire substrate; next, coating two layers of photoresist films and the lower layer of photoresist film has better photosensitivity; next, exposing and developing the substrate to form a photoresist film graph; then carrying out magnetron sputtering to a second layer of aluminous film, and dipping the aluminous film in solvent to remove the outer layer aluminous film; finally processing the substrate at lower temperature and then high temperature to form the graphical sapphire substrate with single crystal alumina film. The preparation method is simple and easy to implement, which overcomes the problems that the dry etching method will pollute and damage substrate as well as overcomes the problems that the wet etching method will cause graphic distortion.

The invention discloses 5-iodine-4-sulfur-2'-deoxyuridine, and derivatives and a synthetic method of the 5-iodine-4-sulfur-2'-deoxyuridine. The synthetic method comprises the steps of using 5-iodine-2'-deoxyuridine as main raw material, treating by using acetic anhydride under a certain conditions to obtain 3', 5'-O-dioxo acetyl-5-iodine-2'-deoxyuridine, reacting under the action of phosphorus pentasulfide, then, introducing ammonia to saturated methanol solution, stirring and deprotecting at the room temperature to obtain 5-iodine-4-sulfur-2'-deoxyuridine. According to the invention, the compound and the derivatives have greatest absorption with the ultraviolet spectrum at 345 nm and stronger UVA photosensitivity. Therefore, the compound provided by the invention is a new basic base sulfur-containing nucleosides compound, can alternatively acts on cancer cells and has potential medical value; besides, the synthetic method provided by the invention has the advantages of simple reaction conditions, accessible raw material, low cost, high product yield, high purity and high efficiency.

The invention relates to a method for preparing a nano composite polyurea coating. The method comprises the following steps of: firstly, preparing a coating component A; secondly, preparing a component B mixed with nano powder; thirdly, adding the component A and the component B mixed with the nano powder into a connected spraying device respectively and heating the mixed materials to 65 to 75 DEG C; and when the nano composite polyurea coating is sprayed, controlling the pressures of the pressure meters of the component A and the component B mixed with the nano powder to be between 1,200 and 1,500 pounds per square inch and controlling the pressure difference of the two to be less than 200 pounds per square inch to perform spraying so as to obtain the nano composite polyurea coating. The method for preparing the nano composite polyurea coating has the advantage that: the technical scheme is adopted, so the nano composite polyurea coating prepared by the method has reduced photosensitivity and micro-flaws, improved wear resistance and corrosion resistance and high controllability and high operability.

The invention relates to novel high-elasticity environment-friendly latex paint. The latex paint is prepared from the following components in parts by weight: 25 to 40 parts of water, 25 to 40 parts of modified acrylic emulsion, 15 to 30 parts of pigment, 5 to 8 parts of a filler, 3 to 7 parts of washed kaolin, 15 to 30 parts of ground calcium carbonate, 1 to 3 parts of a dispersing agent, 0.2 to0.6 part of a defoaming agent and 1 to 3 parts of a coalescing agent. The latex paint has the following beneficial effects: (1) the acrylic emulsion modified by organosilicon and epoxy resin can effectively improve the elasticity of the latex paint, and increase the mechanical properties and high / low temperature resistance; (2) the aluminum oxide coated titanium dioxide is adopted, so that the photosensitivity of the titanium dioxide can be effectively protected, and the weather resistance of the emulsion paint is improved; and (3) the emulsion paint prepared by the invention is simple in construction process, good in film forming process, strong in weather resistance and good in elasticity, and can be widely applied to indoor or outdoor decoration.

The invention relates to a medicinal composition, and in particular relates to a medicinal composition for treating photosensitive dermatoses as well as a preparation and a preparation application thereof. The medicinal composition contains the following components: sweet wormwood herb, buffalo horn, rehmannia root, root of largeleaf gentian, tree peony bark, red peony root, divaricate saposhnikovia root and licorice root. The medicinal composition provided by the invention has the advantages of improving the photosensitive state of skins, relieving clinical symptoms of patients, and being relatively good in curative effect and small in side effect, has the effects of clearing away heat and removing dampness as well as cooling blood to remove ecchymoses, can relieve physical symptoms of erythema, blisters and the like, can relieve the symptoms of rash swelling, scorching hot stabbing pain, thirsty, vexation irritability, dry stool, scanty yellowish urine and the like, can be used for treating the photosensitive dermatoses, and can also improve the tolerance and adaptability of patients to sunlight toxic factors.

The present invention relates to a composition comprising a photosensitizing agent and a skin-penetration enhancer. The composition herein show improved delivery of the photosensitizer through the stratum corneum. In addition, the composition of the present invention show improved stability and a reduced incidence of skin photosensitivity.

The invention provides magnetic nanoparticles with a dual-heating function and a preparation method thereof. The preparation method is characterized in that ferroferric oxide (Fe3O4) nanoparticles are prepared and serve as cores, and the magnetic induction of the ferroferric oxide nanoparticles is used for targeting tumor cells and carrying out the magnetic thermal therapy; and gold is used as shells of the magnetic nanoparticles, and the photosensitivity of the gold is used for carrying out near-infrared thermal therapy; and the constructed novel Fe3O4@Au compound magnetic nanoparticles can simultaneously serve as a magnetic induction agent and a photosensitizer for tumor thermotherapy. The compound magnetic nanoparticles prepared by the method are injected into an animal model for tumor and can be used for carrying out magnetic thermal therapy and photo-thermal therapy on a living animal model. The treatment effect of the magnetic nanoparticles on tumor is obviously superior to that of a single treatment method.

A molecular label of magnetic particles, which can be optically excised, is prepared by linking the photosensitive molecular radial to the magnetic particle. It can be used to synthesize the high-purity complete-length target polypeptide through derivation marking to conventional solid polypeptide, cutting, magnetic separation, optically excising the molecular label, and final separation.

The invention relates to a light-sensitive Zr-B-Si-C ceramic precursor and an in-situ preparation method thereof. The method comprises the following steps: uniformly mixing methylvinyldichlorosilane and a borane dimethyl sulfide complex, and then adding metal sodium for dechlorination to obtain methylvinyl borosilane; uniformly mixing chloromethyltrichlorosilane, methylchloromethyldichlorosilane and bis(cyclopentadienyl)zirconium dichloride, then adding metal magnesium to carry out a first heat preservation reaction, and then adding a reducing agent to carry out a second heat preservation reaction to obtain polyzirconocarbosilane; uniformly mixing methylvinyl borosilane and polyzirconocarbosilane to obtain vinyl Zr-B-Si-C alkane; and uniformly mixing the vinyl Zr-B-Si-C alkane with mercaptopropionate, and then adding a photoinitiator to initiate a polymerization reaction to prepare the ceramic precursor. The problems of high viscosity, high thermal stress, structural member mechanicalproperty attenuation and the like of a traditional photocuring system are solved, and a high-quality raw material is provided for photocuring 3D printing of an ultrahigh-temperature ceramic structuralmember.

The invention relates to a chrysanthemum photoperiod-sensitive gene CmFT and application of the CmFT gene in chrysanthemum photoperiod sensitivity. In the invention, the CmFT, an FT homologous gene, is separated out from chrysanthemums by using a homologous gene cloning method as well as a RACE technology, the gene has a nucleotide sequence as shown in SEQ ID No.1, and the CmFT belongs to FT subfamily members. The CmFT is relevant to chrysanthemum photosensitivity. After transforming the gene into model plant Arabidopsis thaliana and common chrysanthemum varieties by genetic transformation, the result shows that the gene can adjust the photoperiod of chrysanthemums and promote flowering.

The invention relates to a cold / thermal light source double-response fluorescence chameleon fiber and preparation and application thereof. The fiber is a core-shell structure fiber with uniform fineness, and comprises a polylactic acid shell layer and two parallel core layers, wherein the two parallel core layers are a cold light source-induced fluorescent ink and polyvinyl alcohol mixture and a thermal light source-induced chameleon ink and polyvinyl alcohol mixture. The fiber disclosed by the invention has photosensitivity and temperature sensitivity, two effects of fluorescence and chameleon are simultaneously existent in the core of one fiber, so that the fiber can be extensively used for a product anti-counterfeiting mark, textile and garment such as special garment, aviation and navigation, national defense industry, building decoration, transportation, nightwork, daily life, leisure and entertainment and like fields.

The invention discloses a polyene structure-containing donor-acceptor Stenhouse adduct and a preparation method thereof, and belongs to the technical field of donor-acceptor Stenhouse adducts. According to the invention, cheap and easily available olefine aldehyde compounds are used as substrates, the cost is low, the whole synthesis route uses organic alkali as a catalyst, the yield of a target compound is improved, and the characteristics of high efficiency and low toxicity are realized; and the triene conjugated structure of a donor-acceptor Stenhouse adduct is expanded into a tetraene and pentaene structure, such that the structural range of the donor-acceptor Stenhouse adduct is substantially enriched, the photosensitive property of the donor-acceptor Stenhouse adduct is effectively regulated, and the donor-acceptor Stenhouse adduct can be applied to more fields, and has scientific and practical values.

The invention discloses a preparation method of castor oil-based polyamide capable of being cross-linked by ultraviolet light, and relates to the technical field of macromolecules, the preparation method comprises the following steps: (1) adding castor oil-based functional polyamide and a photo-crosslinking functional monomer into tetrahydrofuran, and heating until dissolving; (2) dissolving dimethylaminopyridine in tetrahydrofuran, and then mixing with the mixture obtained in the step (1); and (3) dissolving a dehydrating agent in tetrahydrofuran, then mixing with the mixture obtained in the step (2), carrying out sealed reaction at 65 DEG C for 12 hours, and purifying to obtain a polymer, namely the ultraviolet-crosslinkable castor oil-based polyamide. The invention also provides a product obtained by the method and application thereof. The castor oil-based polyamide has the beneficial effect that the ultraviolet light sensitive side group endows the castor oil-based polyamide with light sensitivity. According to the invention, the preparation of the castor oil-based photo-crosslinked polyamide elastomer is realized, so that the bio-based polyamide elastomer has ultraviolet light crosslinking functionality, and the application field of castor oil-based polyamide is expanded.

The invention discloses a preparation method of a photochromic material based on boron cluster anions, which comprises the following steps: adding conjugated polypyridine molecules into ultrapure water, regulating the pH value to -1-7 with an inorganic acid, and carrying out ultrasonic stirring at room temperature until the solution is completely clear and transparent to obtain a solution A; and adding an aqueous solution containing a boron cluster compound into the solution A, continuously stirring for 0.5-24 hours after generating a precipitate, filtering to obtain a precipitate, washing, and carrying out vacuum drying to obtain the photochromic material based on boron cluster anions. The method is mild in reaction condition, simple in process and easy to operate. The absorption spectrumdifference before and after material discoloration is large, and preparation cost is low. The synthesized material has the advantages of higher photosensitivity, quicker discoloration and longer freeradical service life. A reference thought is provided for subsequently utilizing the photochromic material in the application fields of biological treatment, photoelectric conversion and the like, and the photochromic material has a great application prospect in the aspect of photoelectrocatalysis.

The invention provides a positive photoresist composition and a preparation method and application thereof, and relates to the technical field of photoresist preparation, the positive photoresist composition comprises phenolic resin, a cross-linking agent, an acid catalyst, a photoinduced deactivator and an optional solvent, and the photoinduced deactivator comprises an anionic initiator. The positive photoresist composition belongs to chemical amplification photoresist, the phenolic resin in the positive photoresist composition has excellent physical and chemical properties, proper dissolution rate and good film-forming property, in a non-exposure area, an acid catalyst catalyzes a cross-linking agent to be subjected to a cross-linking reaction with the phenolic resin, and after the positive photoresist composition is exposed by ultraviolet light with the wavelength of 365 nm or 436 nm in an exposure area, the compound generated by the anionic initiator deactivates the acidic catalyst and does not catalyze the cross-linking reaction any more. According to the invention, the technical problem of large exposure dose demand caused by poor photosensitivity of the photoresist is solved, and the technical effects of high photosensitivity of the photoresist, small exposure dose demand, improvement of production efficiency and reduction of production cost are achieved.

This invention provides methods for determining photosensitive properties of product materials by exposing the product materials to controlled light exposures and measuring for changes in the product materials to quantify light sensitivity.

The invention belongs to the technical field of high polymer material preparation, and particularly relates to polyurethane, single-component light-sensitive reversible hydrogel and a preparation method and application of the single-component light-sensitive reversible hydrogel, a side chain of the polyurethane contains a beta-cyclodextrin (beta-CD) group and an azobenzene group, a main chain is based on polyethylene glycol, the preparation method is simple, and the content of functional groups is easy to control; the hydrogel prepared on the basis of the polyurethane has high photosensitivity and high response speed to white light and ultraviolet light media, can realize solution-gel-solution circulation along with irradiation of ultraviolet light-white light-ultraviolet light, and can be repeatedly used for multiple times; the hydrogel is extremely sensitive to light rays, the time T (liquid-gel) for converting a solution into a gel state is 0.5-1.5 min, the time T (gel-liquid) for converting the gel into a liquid state is 5-10 min, and the hydrogel shows excellent light response speed; the hydrogel has relatively high anti-cracking strength, and the anti-cracking strength can reach 5 to 20 kPa.

The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.

The invention provides photosensitive resin, a preparation method and an application thereof. The photosensitive resin has a structure as shown in a formula I, is an alkali-soluble resin, and heat resistance, stability and photosensitivity can be remarkably improved through a special design of a molecular structure and introduction of anthracene ketone groups. The photosensitive resin can be subjected to a chemical crosslinking reaction under light irradiation to form a stable condensate insoluble in an alkali liquor so that a photoresist composition containing the photosensitive resin has excellent developing performance, adhesion, pattern precision and thermal stability. The photosensitive resin is suitable for a negative photoresist composition and is especially suitable for photoresistfor a black matrix, and a pattern obtained after exposure and development has good collimation, resolution and the excellent thermal stability. The photosensitive resin can be used for preparing a high-precision microstructure, and a stability requirement of the photoresist for multiple high-temperature baking processes in a processing process can be fully met.

The invention belongs to the field of preparation of nano noble metal particle-containing hybrid microgel materials, and particularly relates to nano gold-containing polyvinyl pyrrolidone / poly (N-vinylcaprolactam) hybrid microgel and a preparation method of the nano gold-containing polyvinyl pyrrolidone / poly (N-vinylcaprolactam) hybrid microgel. The preparation method comprises the following steps: firstly, synthesizing polyvinyl pyrrolidone / poly (N-vinylcaprolactam) intelligent composite microgel through a seed soap-free emulsion polymerization method, and then reacting with a chloroauric acid (HAuCl4) solution by utilizing the reducibility of the polyvinyl pyrrolidone component in the microgel, so as to reduce gold ions into simple substance nanogold. And changing synthesis conditions and experimental formulas to obtain the hybrid microgels with different forms, different gold nanoparticle contents and different performances. In the final product, the size of the gold nanoparticles is 5-80 nm, and the size of the gold nanoparticles can be regulated and controlled through reaction conditions. The obtained hybrid microgel material organically combines the photo-thermal conversion capability of the gold nanoparticles and the temperature sensitivity of the microgel, and has special photosensitivity.

The invention discloses a polyimide positive photoresist based on an alkali deactivation mechanism, which comprises the following components in percentage by weight: 10-50% of polyamide acid resin, 10-50% of alkaline catalyst, 10-50% of photo-acid generator and 10-50% of solvent, and the sum of the components is 100%. 0.5%-10% of a basic catalyst; 0.5%-10% of a photoacid generator; and 50%-90% of a solvent. The invention provides a polyimide positive photoresist based on an alkali deactivation mechanism, the photoresist belongs to a chemical amplification photoresist, the photosensitivity is strong, the exposure dose can be reduced to 50-70mj / cm < 2 > by taking the photoresist thickness of 3 microns as an example, meanwhile, the imidization photoresist thickness loss is smaller, the production efficiency of customers can be greatly improved, and the production cost is reduced.

The invention relates to a preparation method for graphical sapphire substrate for epitaxial growth of nitride, which comprises the following steps of: firstly, magnetron sputtering a layer of aluminous film on the sapphire substrate; next, coating two layers of photoresist films and the lower layer of photoresist film has better photosensitivity; next, exposing and developing the substrate to form a photoresist film graph; then carrying out magnetron sputtering to a second layer of aluminous film, and dipping the aluminous film in solvent to remove the outer layer aluminous film; finally processing the substrate at lower temperature and then high temperature to form the graphical sapphire substrate with single crystal alumina film. The preparation method is simple and easy to implement, which overcomes the problems that the dry etching method will pollute and damage substrate as well as overcomes the problems that the wet etching method will cause graphic distortion.

The invention relates to a dual-responsive color-changing polylactic acid fiber and preparation and application thereof. The dual-responsive color-changing polylactic acid fiber includes a polylacticacid shell layer, first fibers and second fibers, wherein an inner cavity is symmetrically filled with the first fibers and the second fibers in a length direction; the first fibers are compound fibers containing photochromic ink; and the second fibers are compound fibers containing thermochromic ink, and the first fibers and the second fibers form an interface. The dual-responsive color-changingpolylactic acid fiber has temperature sensitivity and photosensitivity, the core of one fiber has two colors and color-changing effects at the same time, and the dual-responsive color-changing polylactic acid fiber can be used in the fields of military camouflage, anti-counterfeit marking of products, ultraviolet high temperature warning protection, decorative clothing and the like.

The invention relates to the technical field of agricultural breeding, in particular to a soybean sterile gene mutant, a construction method and application of the soybean sterile gene mutant in photosensitive fertility regulation. The soybean sterile gene mutant provided by the invention is located in a soybean chromosome 2, and an abnormality exists in a PHD-finger structural domain region of an ORF2 gene, so that compared with a wild type, the gene mutant has the advantages that the PHD-finger structural domain transcription is terminated in advance or the PHD-finger structural domain function is lost after smooth expression, thereby finally changing the fertility of the soybean and causing pollen abortion of the mutant. Through identification, the fertility of the soybean containing the mutant also shows photosensitivity, and the adjustment of the fertility of a plant transformed with the mutant soybean can be realized by adjusting the illumination length, so that a brand-new sterile line resource is provided for soybean hybrid seed production or sterile line seed reproduction; and the risk caused by failure of other sterile line resources due to a certain reason is avoided.

Disclosed is an agent for inhibiting or reducing light sensitivity comprising a substance that inhibits or reduces ubiquitination, for example, an agent for inhibiting or reducing light sensitivity capable of protecting a retina, reducing retinal degeneration, reducing aging of a retina and / or reducing hyperesthesia. The present invention is suitable for use in amelioration or prevention of a symptom associated with light reception, such as age-related macular degeneration, retinitis pigmentosa, Leber congenital amaurosis, Stargardt disease, cone-rod dystrophy, diabetic retinopathy, macular edema, retinal ischemia, photosensitive seizure, photosensitive epilepsy, psychiatric disorders, photic maculopathy, asthenopia, retinal dysfunction, sleep disorders, migraine and light-induced damage.

The invention discloses a preparation method of a double-sensitivity cyclodextrin supermolecule aggregate, belonging to the technical field of functional materials. The preparation method comprises the following steps of preparing a host molecule-photosensitive 4-hydroxycinnamic acid-cyclodextrin (4HCA-CD) by using 4-hydroxycinnamic acid (4HCA) to modify beta-cyclodextrin (beta-CD); using trithioester with adamantine (AD) at tail end as a chain transfer agent, and preparing temperature-sensitive object polymer-double-arm adamantine-poly(N-isopropyl acrylamide)-adamantine (AD-PNIPAM-AD) by using a reversible addition-fragmentation chain transfer free radical polymerization (RAFT) method; constructing a double-sensitivity supermolecule inclusion complex 4HCA-CD / AD-PNIPAM-AD by utilizing comprehensive performance of a beta-CD dewatering cavity and AD; and self-assembling the 4HCA-CD / AD-PNIPAM-AD to form the supermolecule aggregate which is capable of realizing reversible conversion in shape and size by changing light and temperature. The supermolecule aggregate prepared by the preparation method disclosed by the invention has good light / temperature double sensitivities and is capable of carrying out smart response onto external stimulus, so that the supermolecule aggregate has a wide application prospect in the fields of drug loading, controlled release, and the like.