The invention provides a mixed treatment technology of copper and lead anode slime. The mixed treatment technology comprises the technical steps that crude selenium and calcine are obtained after copper anode slime is subjected to sulfatizing roasting, a selenium dioxide product is obtained after crude selenium is subjected to oxidation, calcine is rinsed, and copper is removed; decoppering slagsare mixed with lead anode slime after being dried, a mixture of the decopper slags and lead anode slime is subjected to reduction smelting through a bullion lead furnace, soot, slags and primary bullion lead are obtained, and antimony is recycled from soot and the slags; primary bullion lead enters an antimony removing furnace, antimony is removed, antimony soot and secondary bullion lead are obtained, antimony is recycled from antimony soot, and secondary bullion lead is subjected to oxidation refining through a silver-smelting furnace; bismuth slags, tellurium slags, soot and a silver anodeplate are obtained through oxidation refining of the silver-smelting furnace, bismuth is recycled from the bismuth slags, tellurium is recycled from the tellurium slags, soot returns to a pyrometallurgy system to be treated, and the silver anode plate is subjected to silver electrolysis; and silver powder and black gold dust are generated through silver electrolysis, gold is recycled from black gold dust, silver powder is molten, and silver ingots are generated through pouring. According to the technology, mixed treatment of copper and lead anode slime and comprehensive recovery of various valuable metals like gold, silver, copper, lead, selenium, antimony, bismuth, tellurium are mainly achieved, and the problem that the quantity of wastewater generated in a traditional copper anode slimetreatment technology is effectively solved.