The invention prepares an interventional cardiac valve prosthesis based on anisotropic polymer fiber composite material valve leaflets. Anisotropic polymer fiber cloth is seamed in a metal stent, so that a self-expanded (such as nickle-titanium alloy stent material) or self-expanded (such as cobalt-chromium alloy stent material) interventional valve stent prosthesis is prepared; and photo-crosslinking or chemical crosslinking polyethylene glycol hydrogel covers the surface of the polymer fiber material. The interventional cardiac valve prosthesis provided by the invention, which is prepared from polymer fiber cloth having anisotropic mechanical performance, such as polyester, polyurethane, polytetrafluoroethylene or a composite material thereof, can simulate a stress distribution state ofa human body aortic valve under a blood flow effect, so that mechanical performance, which is similar to that of human body valve, can be achieved, and subsequently, the fatigue resistance of the valve leaflets can be improved. In addition, by combining the polyethylene glycol hydrogel on the surface, the integration of the valve leaflet material is guaranteed, and moreover, an anti-fouling function is achieved; platelet adhesion and protein adsorption can be relieved; and good bio-compatibility can be achieved.