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Interventional cardiac valve prosthesis based on polymer fiber composite material and preparation method of interventional cardiac valve prosthesis

A technology of artificial heart valves and polymer fibers, applied in heart valves, coatings, medical science, etc., to achieve good hydrodynamic performance, improve radial compliance, and reduce protein and platelet adhesion effects

Inactive Publication Date: 2018-11-30
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned shortcomings of the artificial mechanical valves and biological valves currently used clinically, the present invention provides an interventional artificial heart valve based on polymer fiber composite materials and a preparation method thereof. The prepared heart valve prosthesis is hydrodynamically Its important technical indicators such as effective opening area and reflux ratio all meet the ISO5840 international standard, which has important clinical application value

Method used

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  • Interventional cardiac valve prosthesis based on polymer fiber composite material and preparation method of interventional cardiac valve prosthesis
  • Interventional cardiac valve prosthesis based on polymer fiber composite material and preparation method of interventional cardiac valve prosthesis
  • Interventional cardiac valve prosthesis based on polymer fiber composite material and preparation method of interventional cardiac valve prosthesis

Examples

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Effect test

Embodiment 1

[0035] Raw materials and requirements: polyethylene terephthalate / polyamide 6 composite polymer fiber material, polyethylene glycol, acryloyl chloride, PBS solution, ethanol, ultrapure water (chemical reagents are all analytical grade).

[0036] PEGDA synthesis: Polyethylene glycol diacrylate (PEGDA) is prepared by reacting polyethylene glycol (PEG) with acryloyl chloride;

[0037] A nickel-titanium alloy thin-walled tube with an outer diameter of 7 mm and a wall thickness of 0.5 mm was laser-engraved, heat-treated, shaped, and polished to prepare a self-expanding stent with a bottom diameter of 23 mm;

[0038] Cutting of polymer fiber material: According to the shape and size of the metal bracket, the polyethylene terephthalate / polyamide 6 composite polymer fiber cloth is cut into such image 3 (a) The shape shown; the polymer fiber cloth is made of directional weaving of polyethylene terephthalate / polyamide 6 composite polymer fiber bundles ( figure 2 (a)); the weaving met...

Embodiment 2

[0047] In this example, a self-expanding interventional valve prosthesis with a stent bottom diameter of 25 mm was prepared. A nickel-titanium alloy thin-walled tube with a diameter of 7 mm was laser-engraved, then heat-treated, shaped, and polished to prepare a self-expanding stent. The bottom diameter of the stent was 25 mm, and the rest were the same as in Example 1.

[0048] The various performance tests of the valve prosthesis prepared in this example are basically the same as those in Example 1.

Embodiment 3

[0050] In this example, a self-expanding interventional valve prosthesis with a diameter of 23 mm at the bottom of the stent was prepared using polyurethane fiber material. Cut the polyurethane fiber material into a suitable shape and sew it inside the metal bracket, and the rest are the same as in Example 1.

[0051] The various performance tests of the valve prosthesis prepared in this example are basically the same as those in Example 1.

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Abstract

The invention prepares an interventional cardiac valve prosthesis based on anisotropic polymer fiber composite material valve leaflets. Anisotropic polymer fiber cloth is seamed in a metal stent, so that a self-expanded (such as nickle-titanium alloy stent material) or self-expanded (such as cobalt-chromium alloy stent material) interventional valve stent prosthesis is prepared; and photo-crosslinking or chemical crosslinking polyethylene glycol hydrogel covers the surface of the polymer fiber material. The interventional cardiac valve prosthesis provided by the invention, which is prepared from polymer fiber cloth having anisotropic mechanical performance, such as polyester, polyurethane, polytetrafluoroethylene or a composite material thereof, can simulate a stress distribution state ofa human body aortic valve under a blood flow effect, so that mechanical performance, which is similar to that of human body valve, can be achieved, and subsequently, the fatigue resistance of the valve leaflets can be improved. In addition, by combining the polyethylene glycol hydrogel on the surface, the integration of the valve leaflet material is guaranteed, and moreover, an anti-fouling function is achieved; platelet adhesion and protein adsorption can be relieved; and good bio-compatibility can be achieved.

Description

technical field [0001] The invention relates to the technical field of artificial heart valves, in particular to an interventional artificial heart valve based on a polymer fiber composite material and a preparation method thereof. Background technique [0002] Heart valve disease is a serious heart disease with a high incidence in my country, among which valve damage caused by rheumatic fever is the most common. With the aging of the population, valvular disease caused by senile valvular disease, coronary heart disease, and myocardial infarction is becoming more and more common. At present, the main clinical treatment for heart valve disease is to replace the diseased valve with an artificial heart valve prosthesis. The valve prosthesis widely used in clinical practice includes mechanical valves and biological valves. However, after mechanical valve replacement, anticoagulant drugs need to be taken for life, and biological valves are also prone to problems such as decay an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/04A61L27/34A61L27/50A61L27/52A61F2/24
CPCA61F2/2415A61F2/2418A61L27/045A61L27/06A61L27/34A61L27/50A61L27/52A61L2430/20C08L71/02C08L75/04
Inventor 张兴郭峰白芸杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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