202 results about "Artificial heart valve" patented technology

The present invention is directed to methods and devices for repairing a cardiac valve. Generally, the methods involve a minimally invasive procedure that includes creating an access in the apex region of the heart through which one or more instruments may be inserted so as to repair a cardiac valve, for instance, a mitral or tricuspid valve. Accordingly, the methods are useful for performing a variety of procedures to effectuate a repair. For instance, in one embodiment, the methods are useful for repairing a cardiac valve by implanting one or more artificial heart valve chordae tendinae into one or more cardiac valve leaflet tissues so as to restore the proper leaflet function and thereby prevent reperfusion. In another embodiment, the methods are useful for repairing a cardiac valve by resecting a portion of one or more cardiac valve leaflets and implanting one or more sutures into the resected valve tissues, which may also include the implantation of an annuloplasty ring. In an additional embodiment, the methods are useful for performing an edge to edge bow-tie repair (e.g., an Alfieri repair) on cardiac valve tissues. Devices for performing the methods of the invention are also provided.

An artificial heart valve and weaving method thereof are disclosed. The valve stent includes a tubular stent (10), valve leaflets (33), sealing membranes (351, 354), x-ray opaque markers (311, 312) and flexible connecting loops (41). The middle segment (15) of the net stent (10) is tubular or drum-shaped, or provided with radial protrusion structures (153), or provided with outer annular structures (155), or provided with outer free tongues (156), or provided with radial protrusion structures (153) and outer free tongues (156). The stent can be made by up and down interweaving the same one elastic metal wire, and also can be made by up and down interweaving different elastic metal wires. Moreover, the structure, shape and function of the valve stent are optimized; in radical compression, the valve can be transported to the right place with the help of interventional device; after expansion, fitted with figure of the vascular wall in the radical and axial direction, the artificial heart valve stent will not produce paravalvular leak; even more after implanting, the valve has a normal effect on prevent the slippage of artificial valve, which is caused by the blood reflux through the closed valve.

An artificial heart valve comprising a tubular base body having sinuse(s) of Valsalva and valve cusp(s) provided inside the base body, characterized in that the base body and the valve cusps comprise a bioabsorbable polymer material.

Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture / guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening / closing of the valve.

The invention relates to an artificial heart support valve, wherein it comprises tubular mesh support, valve blade, sealing film, impermeable x-ray mark, and flexible coiple ring; the middle part of mesh support is round or cylinder, or arranged with radial protrusion, or arranged with outer annular structure, or arranged with outer free tone, or arranged with radial protrusion and outer free tone. The invention can radial compress to transmit into accurate position via medium device, to be expanded, while the expanded valve will meet the shape of valve, without leakage. The invention can avoid being pushed when the blood refluxes and it is closed.

Heart valve attachment apparatus and methods that significantly reduce attachment times are provided. The apparatus and methods utilize a connector band to form an interface between a uni-directional valve and a tissue annulus. The connector band is secured to the tissue annulus by retention fingers.

Methods and devices for repairing a cardiac valve. A minimally invasive procedure includes creating an access in the apex region of the heart through which one or more instruments may be inserted. The device can implant artificial heart valve chordae tendineae into cardiac valve leaflet tissues to restore proper leaflet function and prevent reperfusion. The device punctures the apex of the heart and travels through the ventricle. The tip of the device rests on the defective valve and punctures the valve leaflet. A suture or a suture / guide wire combination is inserted, securing the top of the leaflet to the apex of the heart. A resilient element or shock absorber mechanism adjacent to the outside of the apex of the heart minimizes the linear travel of the device in response to the beating of the heart or opening / closing of the valve.

In an artificial heart valve for the replacement of an aortic or a mitral valve, including an annular body, which is provided at its outer circumference with means for mounting the artificial valve in place by surgical procedures and which defines in its interior a blood flow passage in which valve flap elements are pivotally supported so as to open or close the blood flow passage depending on their pivot positions, the annular body includes circumferentially spaced projections extending into the flow passage and being provided at their inner ends with pivot joints on which the valve flap elements are pivotally supported.

The invention is directed to methods for preparing artificial heart valves by preconditioning a matrix seeded with endothelial cells and smooth muscle cells differentiated from isolated progenitor cells. These cell seeded matrices are exposed to fluid conditions that mimic blood flow through the heart to produce tissue engineered heart valves that are analogous to native heart valves.

The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures / tethers which maintain proximal tension on the valve prior to deployment.

A method of biolization to the surface of inorganic material includes the following steps: the surface is spattered to form a tantalum oxide or a titanium oxide thin film; and then the inorganic material is put in a plasma immersion ion implantation device; after vacuumization, hydrogen, water vapour or ammonia is fed in, with gas pressure 0.05 to 50 Pa; the radio frequency discharge power is 200 to 1200W; the range value of the loaded pulse high-voltage power is 1KV to 100KV, the frequency is 50 to 40000HZ, and the duty ratio is 3 percent to 80 percent; the heating temperature is 20 to 500 DEG C; the treatment time is 0.1 to 5 hours; finally, the inorganic material is put into 10 to 100mg / mL albumin or heparin solution to be soaked for 2 to 48 hours under 20 to 40 DEG C soaking temperature. The method does not damage the activity of the biomolecule and the protein; the prepared inorganic material with biolized surface has good anti-coagulability, is used for medical blood vessel scaffolds and artificial heart valves, and can greatly improve the product performance.

There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.

There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg / cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

The invention provides an involved artificial heart valve prosthesis.A support of the involved artificial heart valve prosthesis sequentially comprises a first sub-support, a second sub-support and a third sub-support connected in sequence.The first sub-support is a net pipe in a cone frustum shape, the second sub-support is a cylindrical net pipe, and the third sub-support is a trumpet-shaped net pipe.The maximum pipe diameter of the first sub-support is the same as the pipe diameter of the second sub-support.The minimum pipe diameter of the third sub-support is the same as that pipe diameter of the second sub-support.Due to the fact that the first sub-support is designed as the net pipe in the cone frustum shape, compared with an existing support designed as a cylindrical net pipe, the length of the support is reduced through the structure of the first sub-support, and harm caused by the fact that a too long part of the support punctures into the surrounding heart tissue to the heart is avoided.In addition, due to the fact that barbs with a locating function are arranged on the first sub-support, it is avoided that the involved artificial heart valve prosthesis shifts after being released; meanwhile, the structure is matched with the surrounding tissue, a blocking structure can be conveniently formed through membranae tectoria, perivalvular leakage can be avoided, and the success rate of an operation is increased.

The present disclosure concerns embodiments of implantable prosthetic devices, and in particular, implantable prosthetic valves, and methods for making such devices. In one aspect, a prosthetic device includes encapsulating layers that extend over a fabric layer and secure the fabric layer to another component of the device. In particular embodiments, the prosthetic device comprises a prosthetic heart valve, and can be configured to be implanted in any of the native heart valves. In addition, the prosthetic heart valve can be, for example, a transcatheter heart valve, a surgical heart valve, or a minimally-invasive heart valve.

The present invention relates to the fields of chemistry and biology and more particularly to the field of biomaterials. The present invention includes amphiphilic fibers and membranes, which can be used for biomembranes and biocompatible devices. The present invention also relates to processes for preparing amphiphilic fibers and membranes from solutions comprising amphiphilic molecules. More particularly, the present invention relates to processes for preparing fibers and membranes from electrospinning solutions comprising amphiphilic molecules. The present invention further provides fibers and nonwoven membranes comprising amphiphilic fibers chosen from anionic surfactants, cationic surfactants, nonionic surfactants, phospholipids, sulfobetaines, lyotropic liquid crystalline molecules, and / or block copolymers. Electrospun fibers offer the potential for direct fabrication of biologically based, high-surface-area membranes without the use of multiple synthetic steps, complicated electrospinning designs, or post-processing surface treatments. Polymeric phospholipids, for example, have been shown to be attractive candidates for blood purification membranes, artificial heart valves and organs, and other prosthetics, including other biocompatible devices.

The invention relates to an artificial heart support valve, wherein it comprises tubular mesh support, valve blade, sealing film, impermeable x-ray mark, and flexible coiple ring; the middle part of mesh support is round or cylinder, or arranged with radial protrusion, or arranged with outer annular structure, or arranged with outer free tone, or arranged with radial protrusion and outer free tone. The invention can radial compress to transmit into accurate position via medium device, to be expanded, while the expanded valve will meet the shape of valve, without leakage. The invention can avoid being pushed when the blood refluxes and it is closed.

A prosthetic heart valve according to the present disclosure includes a radially collapsible and expandable annular frame and a leaflet structure including a plurality of leaflets mounted within the frame. In particular embodiments, the frame can have a commissural attachment portion configured to support the valve at a location spaced radially inward toward the longitudinal flow axis of the prosthetic valve relative to the frame portion constraining the movable portion of the leaflets. The commissure of the leaflets. As the leaflets open under the pressure of blood flowing through the prosthetic valve, the movable portion of the leaflets is held at a position spaced inwardly from the inner surface of the frame so as not to rub against the leaflets.

A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher.; The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

The invention relates to an artificial heart valve pyrolytic carbon and a testing method for the fracture toughness of a pyrolytic carbon composite material. A testing method for the fracture toughness of the pyrolytic carbon composite material has not been brought forward yet. The testing method provided by the invention comprises the following steps: preparing a plurality of compact tension C(T) specimens from heart valve pyrolytic carbon or a composite material thereof and prefabricating sharp cracks on each specimen, wherein the specimen is of a specification as recommended by American ASTM standard E399, a gap is processed at the central part of the specimen, and upper and lower ends of the gap are respectively provided with a loading hole; then respectively clamping the two loading holes of the gap by using clamps and erecting an extensometer on an open end of the gap; and starting a loading platform to apply an upward load increasing at a uniform speed until the specimens fracture, determining critical load and effective crack length of each specimen, calculating fracture toughness according to the critical load and the effective crack length and taking a mean value as a fracture toughness test value of the heart valve pyrolytic carbon or the composite material thereof. The method provided by the invention can accurately determine fracture toughness of pure pyrolytic carbon and a pyrolytic carbon composite material.

The invention provides a fluorine and silicon-containing polyurethane material with high biostability and belongs to the field of biomedical materials. Polyurethane of the polyurethane material is copolymerized by adopting polyether or polycarbonate diol as a first flexible chain segment, polydimethylsiloxane diol as a second flexible chain segment and diisocyanate and a chain extender as a rigidchain segment, wherein the chain extender is a diol blend of small-molecule diol or diamine and a side chain fluorine-containing alkyl group. By utilizing the low surface energy characteristic of thetwo elements, namely fluorine and silicon, in the process of melt processing or solution processing of the polyurethane, the two elements, namely fluorine and silicon can synergistically migrate to the surface to form a protective layer, water and oxidizing media can be prevented from penetrating into the material to improve the hydrolysis resistance and oxidation resistance of the material, the polyurethane material has excellent surface performance and ontological performance while the biostability is improved, and the material can be applied to the field of long-term implantation of medicalmaterials, such as artificial blood vessels, artificial heart valves, heart pulser wires and various interventional catheters.

A portable artificial heart valve in vitro performance test and circulatory system simulation device can realize the functions of pulsating flow simulation test and fatigue life test. Adding accessories can realize the function of simulating the hemodynamics of different subsystems in the human circulatory system. The device is composed of a flow channel, a driving system, a compliance device, a damping device, a valve fixing device, a function switching device, a temperature control system and an observation system. The flow path is composed of a fatigue life test functional circuit and a pulsating flow simulation test functional circuit. The driving system includes a linear motor, etc., and it connects the valve fixing device one with the flow channel through the rolling diaphragm. The compliance device and the damping device communicate with the flow channel through the interface. The second valve fixing device is installed on the flow channel through the support member. The flow channel has a function switching device interface, a temperature control system interface, and an observation system interface. The whole set of device is novel in conception, exquisite in design, reasonable in structure, good in sealing performance, convenient in valve replacement, small in floor space, and easy to move.

The invention relates to a novel artificial heart valve which is implanted to replace a de-functionalized heart valve by surgical operation or vascular intervention. The novel artificial heart valve comprises a stent and a valve leaflet. The valve leaflet is made of a porcine or bovine pericardium or made of artificially synthesized high polymer material. The stent is composed of an inflow segment and an outflow segment and dilates by the aid of a balloon or by self-expanding. The inflow segment is provided with a self-expanding ring. Soft braided fabric is wrapped around a nitinol wire to form a soft surface. The valve leaflet is attached to the outflow segment to form a valve leaflet segment integrated with the outflow segment. The left-expanding ring has diameter larger than that of the valve leaflet segment and radial holding power larger than that of the valve leaflet segment. The inflow segment is flexibly connected with the valve leaflet segment. The metallic stent of the novel artificial heart valve need not enter a left ventricular outflow tract, and a left ventricle is internally fixed through the self-expanding ring. In addition, the self-expanding ring has smaller supporting power than the valve leaflet segment and the soft surface, so that stress of an endocardium of a left ventricular outflow tract can be lowered evidently, and risks caused by conduction block are reduced.

The present invention is primarily directed a prosthetic cardiac valve support device adapted for endovascular delivery to a cardiac valve, comprising a single ring-shaped support element having an inner diameter and an outer diameter, wherein said support element has an outer perimeter that is entirely rigid, wherein said support element is fitted with one or more intraventricular and / or intra-atrial stabilizing elements, and wherein said support element has a collapsed delivery configuration and a deployed configuration.

The invention relates to a heart valve prosthesis with clamping devices. The heart valve prosthesis comprises a stent and an artificial valve. The stent comprises a heat atrium section, a valve sewing section and at least one clamping device, the artificial valve is fixedly connected onto the valve sewing section, a proximal end of the heart atrium section is fixedly connected with a distal end of the valve sewing section, a reinforcement structure is arranged on the heart atrium section, one end of the reinforcement structure is fixedly connected onto the heart atrium section or is fixedly connected onto materials which are fixedly connected with the heart atrium section and are used for reducing blood or stopping the blood from flowing through the materials, the other end of the reinforcement structure is opened towards the outside of the valve sewing section in natural states, the reinforcement structure and the materials are abutted to autologous valve ring tissues and / or heart atrium tissues after the artificial heart valve prosthesis is completely released, a part of each clamping device is abutted to the outer surface of the valve sewing section in the natural states, at least one bent section which is inwardly bent towards the valve sewing section is arranged on each clamping portion, and a part of each bent portion extends into grid gaps of the valve sewing section.

Apparatus and methods are described herein for anchoring a prosthetic heart valve. In some embodiments, an apparatus includes a tether attachment member that includes a base member (240) that defines at least a portion of a tether passageway (235) through which a portion of a tether (228) extending from a prosthetic heart valve can be received there through. The base member defines a locking pin channel (234) that intersects the tether passageway. A locking pin (226) is disposable within the locking pin channel and movable between a first position in which the locking pin is at a spaced distance from the tether passageway, and a second position in which the locking pin intersects the tether passageway and can engage the portion of a tether disposed therein to secure the tether to the tether attachment member.