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Polypropylene mesh/electro-spinning nano-fiber membrane as well as preparation method and application thereof

A technology of polypropylene mesh and nanofiber membrane, applied in the field of medical devices

Active Publication Date: 2015-11-11
NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, in the field of open abdominal cavity, there is no repair material that can not only protect the exposed intestine, but also promote the proliferation of body tissue, and at the same time provide sufficient repair effect

Method used

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  • Polypropylene mesh/electro-spinning nano-fiber membrane as well as preparation method and application thereof
  • Polypropylene mesh/electro-spinning nano-fiber membrane as well as preparation method and application thereof
  • Polypropylene mesh/electro-spinning nano-fiber membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Polypropylene mesh was purchased from Bard Company, USA. That is, a non-absorbable material woven from polypropylene monofilaments, including a rectangular mesh sheet of about 6cm×4cm.

[0052] 2. Preparation of chitosan-polyethylene glycol hydrogel:

[0053] 1) Polyethylene glycol PEG (molecular weight 3000, 4000gmol -1 ) Dissolve in dichloromethane at 20-28°C in a nitrogen environment, the final concentration of PEG in the solution is 10% (g / 100ml);

[0054] 2) Dissolve 4-dimethylaminopyridine and triethylamine in dichloromethane to obtain mixed solution A, so that the concentration of 4-dimethylaminopyridine and triethylamine in mixed solution A are both 0.375mol / L, and then The mixed solution A is added to the PEG-containing dichloromethane solution prepared in the previous step and stirred for 15 minutes to obtain the mixed solution B. The volume ratio of the mixed solution A to the PEG-containing dichloromethane solution is 1:5;

[0055] 3) Add the mixed solution B d...

Embodiment 2

[0067] 1. Animals and grouping: 20 male SD rats (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), weight

[0068] 230~270g, randomly divided into 2 groups. Experimental group: The polypropylene mesh / nanofiber membrane prepared in Example 1 is cut into a polypropylene mesh / electrospun nanofiber membrane composite patch group (referred to as polypropylene mesh composite nanofiber membrane group) obtained by cutting into appropriate specifications. Control group: polypropylene mesh group.

[0069] 2. Surgical method: Animals are fasted for 8 hours before operation, and 1% ketamine 10ml / kg is injected intraperitoneally. After successful anesthesia, a model of abdominal wall defect caused by cecal ligation and perforation (CLP) combined with abdominal hypertension (IAH) was established. The details are as follows: take the midline incision of the abdomen, 20cm from the ileocecal area, cut off the small intestine circumference 1 / 3, away from the perforat...

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Abstract

The invention relates to a polypropylene mesh / electro-spinning nano-fiber membrane as well as a preparation method and an application thereof. The polypropylene mesh / electro-spinning nano-fiber membrane is prepared through the following steps: (1) preparing a chitosan-polyethylene glycol hydrogel; (2) preparing basic fibroblast growth factor (bFGF) embedded polylactic acid-poly lactic-co-glycolic acid (PLGA) microspheres; (3) preparing an electro-spinning solution; (4) preparing the polypropylene mesh / electro-spinning nano-fiber membrane by use of an electro-spinning method. According to the polypropylene mesh / electro-spinning nano-fiber membrane, the polypropylene mesh and the nano-fiber membrane are compounded creatively, and therefore, the biocompatibility of the polypropylene mesh is improved by use of the nano-fiber membrane and the tensile strength of the nano-fiber membrane is improved by use of the polypropylene mesh, and the polypropylene mesh and the nano-fiber membrane supplement each other; in addition, the microspheres are introduced to realize controlled drug release; as a result, lots of defects of the clinical existing polypropylene meshes can be overcome.

Description

Technical field [0001] The invention belongs to the field of medical equipment, and relates to a polypropylene mesh / electrospun nanofiber membrane and a preparation method and application thereof. Background technique [0002] Experiences and lessons in the treatment of war injuries from the Second World War to the local wars in Afghanistan and Iraq show that the incidence of abdominal war injuries has never dropped significantly, and it has always been the third fatal war injury. Abdominal injuries caused by explosion injuries can cause varying degrees of abdominal wall damage, exposure of abdominal organs, and prolapse of intestines. Abdominal hypertension combined after resuscitation from hemorrhagic shock and traumatic shock can cause the abdominal incision to dehisce, leading to passive opening of the abdominal cavity. In order to treat shock combined with abdominal cavity syndrome (ACS), active abdominal cavity opening is often required. Whether the abdominal cavity is op...

Claims

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Application Information

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IPC IPC(8): D04H13/00D01D1/02A61L31/04A61L31/14
Inventor 任建安陈国璞吴秀文王革非邓友铭黎介寿
Owner NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A
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