Composite material based on silk fibroin fiber and heart valve prosthesis

An artificial heart valve and silk fibroin technology, applied in heart valves, medical science, prostheses, etc., can solve problems such as fibrous hyperplasia and calcification, fatigue tearing of polymer materials, etc., and achieve good long-term fatigue resistance and good fluidity Effects on dynamic properties, enhanced radial compliance and hoop strength

Inactive Publication Date: 2019-09-27
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polymer valves have not been popularized clinically so far, and many polymer materials

Method used

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  • Composite material based on silk fibroin fiber and heart valve prosthesis
  • Composite material based on silk fibroin fiber and heart valve prosthesis
  • Composite material based on silk fibroin fiber and heart valve prosthesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this example, an anisotropic silk fibroin fiber composite material coated with polyethylene glycol hydrogel was used to prepare an artificial heart valve prosthesis with a stent diameter of 25 mm.

[0037] 1. Preparation of silk fibroin solution: Take natural silk and go through the steps of degumming, drying, dissolving, dialysis and concentration to make silk fibroin solution.

[0038] 2. Preparation of fiber material by electrospinning: the concentrated silk fibroin solution is mixed with polyethylene oxide (molecular weight ~ 300000) solution to prepare a spinnable silk fibroin solution. Carry out spinning under the conditions of low silk fibroin solution concentration (the content of concentrated silk fibroin solution in the spinnable silk fibroin solution is 10wt%), low spinning voltage (18kV), first use the drum receiver (number of revolutions) 2800rpm) to collect the anisotropic film and place it on the baffle to collect the isotropic film, and finally obtain...

Embodiment 2

[0046] In this example, an anisotropic silk fibroin fiber composite material coated with polyethylene glycol hydrogel was used to prepare an artificial heart valve prosthesis with a stent diameter of 23 mm.

[0047] 1. Configure silk fibroin spinning solution: same as Example 1.

[0048] 2. Preparation of fiber material by electrospinning: same as in Example 1.

[0049] 3. Coating PEGDA hydrogel: Same as Example 1.

[0050] 4. Cut the silk fibroin fiber composite material according to the required size of the 23mm stent, and place the silk fibroin fiber membrane according to Figure 4 Fold and suture in the manner shown, and suture it inside the stent (diameter 23mm) with medical sutures to make a heart valve prosthesis. When suturing, ensure that the silk fibroin fibers are arranged along the circumference of the valve leaflets, and ensure that the natural state is maintained after suturing. The fit of the three leaflets is good.

[0051] The hydrodynamic evaluation result...

Embodiment 3

[0053] In this example, an isotropic silk fibroin fiber composite material coated with polyethylene glycol hydrogel was used to prepare an artificial heart valve prosthesis with a stent diameter of 25 mm.

[0054] 1. Configure silk fibroin spinning solution: same as Example 1.

[0055] 2. Preparation of fiber material by electrospinning: under the conditions of low silk fibroin solution concentration (10wt.%) and low spinning voltage (18kV), the isotropic film was collected with a baffle. The prepared fiber membrane was carefully torn off from the aluminum foil, immersed in methanol solution to obtain a partially crystallized silk fibroin membrane.

[0056] 3. Coating PEGDA hydrogel: Same as Example 1.

[0057] 4. Cut the silk fibroin fiber membrane according to the required size of the 25mm stent, and place the silk fibroin fiber membrane according to Figure 4 Fold and suture in the manner shown, and sew it inside the stent (25mm in diameter) with medical sutures to make a...

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Abstract

The invention discloses a composite material based on silk fibroin fiber and heart valve prosthesis, and belongs to the technical field of medical materials. Prosthetic valve leaflets are prepared from the silk fibroin fiber with an electrospinning technology, and silk fibroin membrane material valve leaflets with isotropy and anisotropy mechanical properties can be prepared by electrospinning according to different collecting modes respectively. Besides, the surface of a silk fibroin fiber membrane can be coated with polyethylene glycol hydrogel with a photo-crosslinking method, and therefore, the composite material is formed. A space grid structure of the polyethylene glycol hydrogel protects silk fibroin from being degraded by bio-enzyme, and the polyethylene glycol hydrogel has an antifouling function. Anisotropic silk fibroin membrane prepared by electrospinning has mechanical anisotropy, can simulate the stress distribution state of a human aortic valve under the action of blood flow, and has mechanical properties close to those of a human valve.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a composite material based on silk fibroin fibers and an artificial heart valve. Background technique [0002] Heart valve disease is a common and frequently-occurring disease, and heart valve replacement surgery is the most effective surgical method for the treatment of end-stage heart valve disease. Currently, the clinically used replacement valves are mainly mechanical valves (stainless steel, pyrolytic carbon materials, etc.) and biological valves (porcine pericardium, bovine pericardium materials, etc.). complication. Thrombosis is easy to form on the surface of mechanical valve materials, so anticoagulant drugs need to be taken for life after surgery, and biological valves are also prone to problems such as decay and calcification, resulting in a short service life. In recent years, with the continuous development of polymer materials, more and more polymer-base...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/52A61L27/56A61L27/58A61L27/22A61L27/18A61F2/24
CPCA61L27/58A61L27/56A61F2/2415A61F2/2412A61L27/227A61L27/18A61L27/52A61L2430/20C08L71/02C08L89/00
Inventor 张兴郭峰韩日峥杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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