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Polyethylene glycol hydrogel material and preparing method thereof

A polyethylene glycol and hydrogel technology, which is applied in the fields of biochemical equipment and methods, analytical materials, chemical instruments and methods, etc., can solve the problems of few methods for adjusting the mechanical properties of hydrogels.

Active Publication Date: 2017-05-31
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all need to derivatize polyethylene glycol, and there are few ways to adjust the mechanical properties of hydrogels.

Method used

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  • Polyethylene glycol hydrogel material and preparing method thereof
  • Polyethylene glycol hydrogel material and preparing method thereof
  • Polyethylene glycol hydrogel material and preparing method thereof

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preparation example Construction

[0022] The invention provides a preparation method of a polyethylene glycol hydrogel material. After the mixed raw materials are gelled in the presence of a catalyst, the unreacted raw materials are washed and removed, and then the corresponding hydrogel is obtained through hydration. The method comprises the step of reacting the raw material to form a gel under the condition of the presence of the catalyst; the raw material is obtained by uniformly mixing polyethylene glycol, polyhydroxy compound and divinyl sulfone.

[0023] In a specific embodiment, the polyethylene glycol is hydroxyl-terminated polyethylene glycol, without further derivatization, having the structure of general formula i, and the degree of polymerization n≥3. Polyethylene glycol with a polymerization degree of 6≤n≤150 is preferred.

[0024]

[0025] On the other hand, the polyhydroxy compound is selected from glycerol, butylene glycol, polyvinyl alcohol, sugar, multi-armed polyethylene glycol, cellulose...

Embodiment 1

[0033] Preparation of polyethylene glycol hydrogels

[0034] The polyethylene glycol hydrogel is prepared by using hexapolyethylene glycol (n=6) as the polyethylene glycol raw material and glycerol as the polyhydroxy compound raw material. Weigh 0.56g hexapolyethylene glycol (2mmol), 0.96g divinyl sulfone (8mmol), 0.37g glycerol (4mmol), add 0.098g 4-dimethylaminopyridine (0.8mmol, 0.1eq.) and mix well, Stand at room temperature for 12h. The obtained gel was soaked and washed 3 times with ethanol, and washed 3 times with water to obtain a colorless transparent hydrogel material, such as figure 1 shown.

Embodiment 2

[0036] Modulation of Mechanical Properties of Polyethylene Glycol Hydrogels by Polyol Ratio

[0037] Polyethylene glycol hydrogel was prepared by using hexapolyethylene glycol as polyethylene glycol raw material and glycerin as polyol raw material. Weigh 0.56g hexapolyethylene glycol (2mmol), insert 4, 6, 8, 10mmol glycerin respectively, and add divinyl sulfone and 0.1eq 4-dimethylaminopyridine of the amount of corresponding substances, mix and place On the flat plate rheometer, the mechanical properties of the hydrogel prepared under different glycerin ratio conditions were measured, and the results were as follows: figure 2 shown. As the proportion of glycerol increases, the storage modulus of the hydrogel increases; while the loss modulus remains almost unchanged, indicating that the toughness of the hydrogel increases with the proportion of glycerol increasing. This result indicates that the regulation of the mechanical properties of hydrogels can be achieved by adjusti...

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Abstract

The invention discloses a polyethylene glycol hydrogel material and a preparing method thereof. The preparing method includes the steps that under the condition that a catalyst exists, polyethylene glycol, and the raw material obtained in the mode that a polyhydroxy compound and divinyl sulfone are mixed to be even is reacted to form gel. In the preparing method, hydroxyl-terminated polyethylene glycol serves as a raw material, the divinyl sulfone serves as a cross-linking agent, the polyhydroxy compound is added, the network structure is formed, and a one-step reaction is carried out at the room temperature under the catalyst condition. The method is simple, and adjustment of mechanical performance of hydrogel can be achieved by controlling the species and the proportion of the polyhydroxy compound and the chain length of the polyethylene glycol; solvent selection is wide, the polyethylene glycol hydrogel material is suitable for multiple hydroxyl-compound raw materials, and the hydrogel material meeting the requirements is further obtained.

Description

technical field [0001] The invention belongs to the field of organic polymer materials, and relates to a preparation method and application of a novel polyethylene glycol hydrogel with controllable mechanical properties. [0002] technical background [0003] Hydrogel is a material with a polymer network skeleton. Its chemical and physical properties are very similar to the natural cell environment. It has broad application prospects in the fields of medicine, biology, and medicine, and has been widely used in various fields. , such as wound dressings, drug carriers, contact lenses, etc. [0004] Commonly used polymers for making hydrogels include polyethylene glycol, polyvinyl alcohol, and acrylate. Among them, polyethylene glycol (PEG) is widely used due to its good biocompatibility and adjustable mechanical properties. Moreover, polyethylene glycol hydrogel materials are naturally inert to the recognition and adhesion of proteins and cells, so they have a wide range of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L71/02C07C315/04C07C317/18A61K9/06A61K47/10C12Q1/02
CPCA61K9/06A61K47/10C07C315/04C08J3/075C08J3/24C08J2371/02C12N2503/00G01N33/5014C07C317/18
Inventor 程昉王汉奇何炜朱娇慧马晓春曲景平
Owner DALIAN UNIV OF TECH
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