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102 results about "Lymph Gland" patented technology

Stomach computed tomography (CT) sequence image segmentation method based on interactive region growth

The invention discloses a stomach computed tomography (CT) sequence image segmentation method based on interactive region growth, which mainly solves the problems that in the prior art, CT sequence segmentation speed is slow, and poor segmentation is easy to occur. The method includes: firstly, a seed point is selected manually in a target area to be segmented in a first image, the interactive region growth is used for performing segmentation, a center of a segmentation result and eight neighborhoods of the center are projected into a next CT image to serve as seed points, the interactive region growth is continuously used for performing segmentation to obtain the target area of the current image, and the segmentation result of the previous image is projected into a next image repeatedly to serve as a seed point to be segmented continuously until segmentation of a whole sequence is completed. Compared with a traditional serial region growth, the stomach CT sequence image segmentation method based on the interactive region growth has the advantages of being rapid in speed, good in effect and the like, can be used for segmenting stomach CT sequence images, and can well segment target areas which may occur in stomach lymph gland in the sequence.
Owner:XIDIAN UNIV

MRI image-based axillary lymph gland metastasis prediction system

The invention provides an MRI image-based axillary lymph gland metastasis prediction system and relates to the technical field of computer aided diagnosis. The system comprises an input module, an area-of-interest extraction module, a lump segmentation module, a sub-visualization module, a feature extraction module, a feature dimensionality reduction module, a classification and diagnosis module,and an output module. The input module receives a to-be-diagnosed mammary gland DCE-MR image sequence input by a user. The area-of-interest extraction module extracts an area of interest from the mammary gland DCE-MR image sequence. The lump segmentation module segments a lump in the area of interest. The sub-visualization module carries out the visual display on each segmented image and extractsthe edge of a focus. The feature extraction module extracts relevant feature values according to the lump information and transmits the relevant feature values to the feature dimensionality reductionmodule. The feature dimensionality reduction module carries out feature dimensionality reduction on an extracted feature set. The classification and diagnosis module inputs each lump feature value into a classifier. After that, the automatic classification and recognition is carried out by a computer for judging whether a lymph gland has already been transferred or not. The output module displaysa transfer prediction result and a transfer probability. According to the invention, the accurate segmentation of breast lesions can be realized. The accurate diagnosis of mammary axillary lymph glandmetastasis can be effectively assisted.
Owner:NORTHEASTERN UNIV

Lymph gland detection system and method based on stomach computed tomography (CT) image with shape fitting with oval

The invention discloses a lymph gland detection system and a method based on a stomach computed tomography (CT) image with a shape fitting with an oval. The system and the method mainly solve the problem that in an existing stomach CT image, missing inspection exists in automatic aquisition of a suspected lymph gland or left irrelevant information is excessively much. The system comprises a pre-processing module, an interested boundary point detection module, a boundary oval fitting module, an area combination module and a lymph gland tracking and extraction module. The pre-processing module carries out pre-processing on a to-be-detected image. The interested boundary point detection module carries out further processing on the processed image to obtain interested boundary points. The boundary oval fitting module carries out oval fitting on a curve formed by the interested boundary points to obtain an oval-like closed area. The area combination module eliminates ambiguous areas formed in oval intersection. The lymph gland tracking and extraction module carries out window characteristic match and tracking on the suspected lymph gland to complete extraction of the lymph gland. The system and the method can automatically and effectively extract a suspected lymph gland area which a doctor is interested in and ultimately detect the lymph gland, and can be used for medical image processing.
Owner:XIDIAN UNIV

Computer aided gastric cancer diagnosis method based on target tracking

The invention discloses a computer aided gastric cancer diagnosis method based on target tracking and mainly solves the problem of lymph gland transfer judging in a gastric cancer diagnosis process in the field of medical imaging. The steps include 1 segmenting images; 2 extracting tracked targets; 3 forecasting tracking; 4 judging whether all target forecasting tracking is finished, if all target forecasting tracking is finished, a next step is performed, otherwise, the step 3 is returned; 5 matching features; and 6 identifying lymph gland. A method of computer aided medical diagnosis is applied to detection of gastric cancer lymph gland transfer, a large amount of stomach section images can be processed in a short period of time, detecting speed and accuracy rate are improved compared with traditional detection of gastric cancer lymph gland transfer, automatic identification of lymph gland of stomach section images is achieved, clinical diagnosis time is greatly shortened, and a better treatment opportunity is obtained for patients.
Owner:XIDIAN UNIV

Fluorescence navigation system used in tumor surgery

The present invention relates to a fluorescence navigation system used in tumor surgery, which belongs to clinical medicine surgery. The present invention solves problems existing in the surgical excision operation process of tumors that tumor boundaries are difficult to identify, remnant tumor tissue is difficult to recognize, and tumor metastasis lymph glands are difficult to track. The fluorescence navigation system used in tumor surgery is characterized in that the system comprises a biofluorescence excitation light source, a light guide system, a specificity targeted marking fluorescent material, a video camera and an image display and processing device connected with the video camera. The present invention provides fluorescence navigation concept for tumor surgery based on the prior art. When physicians identify tumor boundaries, recognize remnant tumor tissue, and track tumor metastasis lymph glands with a fluorescence observing mirror or a camera display system, tumor tissue is thoroughly excited, operation therapeutic effect is effectively improved, and the death rate of tumor patients is reduced. The present invention makes a breakthrough in tumor surgery.
Owner:SHANXI MEDICAL UNIV

Fully-automatic multi-functional integrated puncture training computer dummy

The invention belongs to the medical teaching equipment technical field and relates to a fully-automatic multi-functional integrated puncture training computer dummy. The fully-automatic multi-functional integrated puncture training computer dummy comprises a high-simulation human body model, a position-automatic changing experimental table, puncture cavities, modules, arteriovenous veins, a liquid injection automatic control device, a fully-automatic arterial pulse simulator and a microcomputer controller. The dummy is characterized in that the high-simulation human body model is installed on the position-automatic changing position experimental table and is provided with various puncture cavities / modules such as pneumothorax, hydrothorax and abdominocentesis modules which are all connected with the microcomputer controller and / or a micro water pump / air pump; double-layer metal mesh electrodes are distributed on the neck, thoracic puncture and lumbar puncture positions of the dummy; the dummy is further provided with kidney, bladder, lymph gland and bone marrow puncture cavities / modules as well as a variety of puncturable central veins and peripheral veins; and arteries are connected with a fully-automatic blood circulation simulator. With the dummy adopted, dozens of puncture items can be provided; puncture position change, liquid injection, gas injection and artery pulsing are completely automated; and sound-light alarms can be given out automatically; life-like simulation effects can be realized; and teaching effects can be significantly improved.
Owner:营口市贵东医疗器械制造有限公司

Double FQ-PCR detection kit for identifying PCV (porcine circoviruses) type 2 and type 3

The invention provides a double FQ-PCR detection kit for identifying PCV (porcine circoviruses) type 2 and type 3. By aiming at the characteristic of low Rep protein and Cap protein gene homology of PCV2 and PCV3, a pair of specific primers and a TaqMan MGB probe (SEQ ID NO:1-6) are designed by using Rep protein gene of PCV2 and Cap protein gene of PCV3 as amplification target regions; the real-time fluorescence quantitative PCR technology is used; the identification detection of the PCV2 and the PCV3 is realized. The detection kit provided by the invention is applicable to viral nucleic aciddetection in samples such as nose swab, oral cavity secreta, faeces, serum, lungs, lymph gland and kidneys of a suspected PCV infectious pig; the sensitivity can reach 1.0*10<1> copy / mu L; the crossedreaction with other pathogene capable of generating mixed infection or with similar of infection symptoms do not exist.
Owner:HENAN CENT FOR ANIMAL DISEASE CONTROL & PREVENTION

Biological self-assembly nanometer crystal injection agent with lympha targeted function and preparation method

The invention discloses a biological self-assembly nanometer crystal injection agent composition with a lympha targeted function and an administration mode for targeting a lymphatic system by using a biological self-assembly nanometer crystal injection agent. A recipe composition is prepared from 0.05 to 5 percent of mitoxantrone and mitoxantrone salt, 0.1 to 10 percent of osmotic pressure regulating agents, 0.001 to 0.1 percent of buffer agents, 0.01 to 0.1 percent of antioxidants, 0.05 to 1 percent of adsorbents and 0 to 20 percent of filling agents. The administration mode is interstitial injection; after the passive lymphatic system targeting, the lymph gland can generate the macroscopic blue color. The problems of poor in vitro and vivo physical and chemical property, poor storage stability, preparation flow process complexity and high cost of the micro particle preparation with the lympha targeted function are solved.
Owner:SHENZHEN CHINA RESOURCES JIUCHUANG MEDICAL & PHARMA CO LTD

Manganese dioxide nanometer adjuvant and preparation method and application thereof

The invention provides a manganese dioxide nanometer material. The manganese dioxide nanometer material comprises manganese dioxide nanoparticles and carried matter, wherein the carried matter is compounded onto the surface of the manganese dioxide nanoparticle; the carried matter comprises oligonucleotide CpG and / or antigen; the antigen comprises protein antigen and / or polypeptide antigen. The provided manganese dioxide nanometer material has the advantages that the immunostimulation function of an immunologic adjuvant CpG is greatly improved, the immunity protection function of vaccine is improved, and the inherent defect of effective improving of immune reaction by a large amount of CpG because the oligonucleotide CpG is used as an immunologic stimulant and cannot easily enter the body lymph glands is solved; the manganese dioxide nanometer material is used as a vaccine adjuvant, and can carry the antigen, especially the protein antigen, so that the intake on the antigen by the immune cells in the lymph glands is effectively improved, and the immunogenicity of the antigen is improved; the nanometer adjuvant can be biologically degraded, and can be gradually degraded into manganese ions (Mn<2+>) under the weak acid environment, such as lysosome, and the manganese ions are finally discharged out of the human body.
Owner:SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD

Diagnosis of prostate cancer

Methods for diagnosing prostate cancer, and differentiate prostate cancer from other prostate complications, and use of said method, and diagnosing and monitoring lymph gland metastasis, post operative examinations, and examinations during or after radiation, cytostatic, and androgen treatments are disclosed. The methods comprise injecting tracer-labelled PSA or hK2 specific antibodies, visualising PSA or hK2 producing tissue with the aid of a visualisation method, and diagnosing prostate cancer from the difference in visualisation.
Owner:JANSSEN BIOTECH INC

Stomach CT image lymph gland recognition system and method based on low-rank decomposition

The invention discloses a stomach CT image lymph gland recognition system and method based on low-rank decomposition. Firstly, suspected lymph glands in a single image are extracted according to the spatial positions and shape characteristics of the lymph glands, and then local self-adaptive windows in one-to-one correspondence to the suspected lymph glands are built considering the fact that lymph glands and blood vessels are difficult to distinguish; if the size of a window is larger than 11*11, a lymph gland tracking and recognition method based on a decolor low-rank model is put forward, the initial frame and terminal frame of the corresponding suspected lymph gland are acquired, and whether the suspected lymph gland is a lymph gland or not is judged according to local-region area changes of the initial frame, the terminal frame and the frame with the largest area; if the size of a window is smaller than 11*11, a lymph gland tracking and recognition method based on region overlapping is put forward, a tracking sequence of the suspected lymph glands is acquired, if the length of the sequence is larger than 10, blood vessel judgment is carried out according to relevant features, and if the length of the sequence is smaller than 10, lymph gland judgment is carried out according to related features. By means of the system and method, lymph glands in a stomach CT image can be automatically and effectively recognized.
Owner:XIDIAN UNIV

Activated carbon nanosphere and application thereof to tumor boundary and lymph gland tracing

The invention discloses an activated carbon nanosphere which is prepared by taking activated carbon particles with the particle sizes of 10-100nm as carriers, and the surfaces of the activated carbon particles are compounded with an organic dyestuff. The activated carbon nanosphere disclosed by the invention is rather strong in dyeing property, remarkable in tracing effect and capable of remarkably showing a lymph tracing effect for a tested living body within half a hour, realizing multi-mode imaging and directly observing the trace of the nanosphere from tumors, tissues or organs through naked eyes.
Owner:SHANGHAI JIAO TONG UNIV

Traditional Chinese medicine composition for treating pulmonary tuberculosis, preparation method and application thereof

The invention relates to a traditional Chinese medicine composition for treating pulmonary tuberculosis, which comprises the following components of lilium brownie, ladybell root, lilyturf root, rehmannia, ginseng, cortex lycii, bulbus fritillariae cirrhosae, radix stemonae,common bletilla pseudobulb, radix astragali, Chinese yam and radix ranunculi ternati. The traditional Chinese medicine composition has the effect of nourishing yin for moistening lung, replenishing qi and invigorating the spleen, and can be used for preparing a medicine for preventing and treating pulmonary tuberculosis and / or lymph gland tuberculosis and / or tuberculous pleurisy. The invention also relates to a preparation method of the traditional Chinese medicine composition, which adopts different extraction methods according to the medicine properties of different herbal medicines to extract effective components in the herbal medicines maximally, thus enhancing medicine effect.
Owner:吉林一正药业集团有限公司

Data processing method in intelligent lymph gland disease diagnostic system

InactiveCN104268566AGuaranteed accuracyThe data feature dimension is smallImage enhancementImage analysisPatient dataFeature selection
The invention discloses a data processing method in an intelligent lymph gland disease diagnostic system. The data processing method is characterized by comprising the following steps that (1) normalization processing is conducted on sample data so that the sample data can be in a preset section range, wherein the sample data comprise the M patient data and the N non-patient data; (2) characteristic selection is conduced on the normalized data based on the P-value algorithm; (3) the characteristics selected in the step (2) are further screened based on forward characteristic selection; (4) an LS-SVM training model is structured according to the characteristics screened out in the step (3); (5) normalization processing is conducted on test data according to the mode in the step (1), the characteristics screened out in the step (3) are selected and brought in the LS-SVM training model structured in the step (4) to conduct classified recognition, and classifying results are output. According to the data processing method, the characteristic dimensions of the data are few when the training model is structured, the diagnostic time is shortened, and meanwhile the accuracy of the diagnostic system is ensured.
Owner:CHONGQING UNIV

Medicine for curing bed sore and ulcer

InactiveCN1408382AInfection effectsInfectionUnknown materialsDermatological disorderMyrrhCurative effect
The medicine for treating bed sore and ulcer is prepared with frankincense, myrrh, pearl, fossil fragemts, borneol and other four kinds of Chinese medicinal materials and through decoction and other steps to form plaster to medicine medicine strip. It has high curative effect on bed sore, bone tuberculosis, lymph gland tuberculosis and various purulent ulcer.
Owner:贾作胜

Antigen capable of increasing CD4 + CD25 + Foxp3 + regulatory T cells and application thereof

InactiveCN101921325ASuppress inflammatory symptomsInhibitory reactivityPeptide/protein ingredientsAntipyreticAntigenDisease
The invention belongs to the immunology field, in particular to a proteantigen molecule-Japanese blood fluke heat shock protein 60KDa (SjHSP60) which is derived from a blood fluke and is capable of increasing CD4 + CD25 + Foxp3 + regulatory T cells and application thereof. The SjHSP60 has a full-length amino acid sequence as shown in SEQ.ID.NO.1, has a series of identical or highly similar cross-reactive T cell epitopes with HSP60 infected by a host. After being used for mouse in vivo immunization or in vitro stimulus to mouse spleen and lymph gland cells, the SjHSP60 can obviously increase CD4 + CD25 + Foxp3 + Tregs. In practical application, the SjHSP60 can effectively relieve inflammatory symptoms and immunopathological effects caused by arthritis, thereby having wide prospects in the aspects of immunological suppression inducement and treatment of immunological diseases.
Owner:NANJING MEDICAL UNIV

Folic acid composite used for imageology diagnosis of tumor and lymphatic metastasis tumor

The invention belongs to the field of pharmaceutical chemistry, relating to a folic acid-polyethyleneglycol composite which can be combined with imageology nuclide for tumor diagnosis, wherein the folic acid composite folic acid, the polyethyleneglycol, functional oligomerized polylysine and a plurality of DTPA are connected in a covalent bond mode. After applying the folic acid composite to animal nuclear magnetic resonance or radioactive video picture diagnosis, experiment results show that the type of the composite is lead to lymphatic system without transmitting blood capillaries at tissue spaces, is dynamically concentrated and eliminated at lymph glands, combines with high-expressive tumor cells of folate receptors in a competitiveness mode, and presents excellent lymph guiding property and accumulative property of tumor locations. The invention can be effectively used for target diagnosis of tumors and metastatic tumors of the lymphatic system, and has high targeting property and high resolution of the tumor and lymphoma diagnosis.
Owner:FUDAN UNIV

Thyroid gland neck tissue classifying and identifying system and method based on autofluorescence technology and optical coherence tomography

Provided are a thyroid gland neck tissue classifying and identifying system and method based on an autofluorescence technology and an optical coherence tomography. The system organically integrates anautofluorescence system and an optical coherence tomography system, utilizes high-sensitivity tissue element resolution capability of the autofluorescence system and high-resolution tissue structureimaging of the optical coherence tomography system to achieve quick, identifier-free, nondestructive, high-sensitivity and real-time thyroid gland neck tissue classification and identification. By adopting the thyroid gland neck tissue classifying and identifying system and method, the classification and identification efficiency and accuracy of doctors to parathyroid glands, thyroid glands, fat,lymph glands and other neck tissues in clinic thyroid gland operation can be effectively improved, the doctors can be assisted to protect the parathyroid glands and thoroughly remove the lymph glands.
Owner:NANKAI UNIV

Lymph gland targeted metastatic human hepatoma cell strain and establishing method thereof

The invention provides a lymph gland targeted metastatic human hepatoma cell strain. The mother cell is a red fluorescent protein-expressed hepatoma cell HCCLM3-R. The human hepatoma cell strain is characterized in that the cell is named as lymph gland targeted metastatic human hepatoma cell strain HCCLM3-R-LnM1 according to the classified nomenclature with a preservation number of 3645, and has the following biological characteristics: the cell is polygonal epithelioid and is in adherent growth and loss of contact growth inhibition, is of a hypo-triploid karyotype, and has 50-58 of chromosomes each of which secretes AFP proteins. The establishing method comprises the following steps: using subcutaneous and liver orthotopic transplantation tumor models of a nude mouse to carry out spontaneous lymphatic metastasis screening, and then carrying out in-vitro cloning, amplification and purification on the lymphatic metastasis human hepatoma cell. The invention has wide application prospects and potential social and economic values in the basic research on hepatoma and the pre-clinic research on medicament.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Double detection method of porcine reproductive and respiratory syndrome virus and bovine viral diarrhea virus from pig

The invention relates to a double RT-PCR detection method of porcine reproductive and respiratory syndrome virus (PRRSV) and bovine viral diarrhea virus from a pig (BVDV), belonging to the biotechnology field. A pair of gene specific primers are respectively designed aiming to the PRRSV and the BVDV, the double RT-PCR detection method of the BVDV and the PRRSV is established, and minimum amounts of cDNA detection of the PRRSV and the BVDV are respectively 3.8*10<-4>ng and 7*10<-4>ng. Samples of a lung, a spleen, a lymph gland and the like of 75 piglets of Jiangsu Province are detected through the method to have a result that 55 are PRRSV positive and 14 are BVDV positive, wherein 12 PRRSVs and 12 BVDVs are mixedly infected, the detection result coincidence rate of the PRRSV and a single RT-PCR and the detection result coincidence rate of the BVDV and the single RT-PCR are respectively 89.3 percent and 92 percent, thereby proving that the established double RT-PCR detection method can be used for detecting the BVDV and the PRRSV in a clinical sample. Compared with a single detection method, the double RT-PCR detection method can save the time and the cost of an experiment and enhance the detection efficiency.
Owner:NANJING AGRICULTURAL UNIVERSITY

Preparation method, formula and use method of bovine mycoplasma pneumonia inactivated vaccine

The invention provides a preparation method, a formula and a use method of a bovine mycoplasma pneumonia inactivated vaccine. The preparation method of the bovine mycoplasma pneumonia inactivated vaccine comprises the following steps: 1, selecting diseased cattle which naturally infect mycoplasma pneumonia and is dying, taking diseased lungs, lymph glands and spleens to homogenize and removing precipitates and grease through filtering and centrifugation to obtain an antigen solution; 2, adding formaldehyde into the antigen solution to inactivate for 72 hours, adding 1,000 units of penicillin and 1,000 units of streptomycin into the antigen solution per millimeter and uniformly mixing to obtain an inactivated antigen solution; 3, mixing the inactivated antigen solution with an aluminum hydroxide adjuvant according to the proportion of 4:1 to obtain the inactivated vaccine. The vaccine prepared by the preparation method is safe in application, strong in pertinence and indeed in immune protection effect on mycoplasma causing bovine pleuropneumonia by infection, the lung lesion score of the infected cattle can be obviously reduced, the material weight ratio is improved, and the good effects of prevention and disease control can be achieved.
Owner:福清市默克兽医院

Traditional Chinese medicine composition for inhibiting tumor growth and preparation method thereof

The invention belongs to the field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for inhibiting tumor growth and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention is prepared from the raw materials including radix aconiti lateralis preparata, cassia twig, asarum, radix scrophulariae, oyster, thunberg fritillary bulb, raw pinellia, ginger, honey-fried licorice root, spreading hedyotis herb, sculellaria barbata, radix ginseng rubra, lucid ganoderma, platycodon grandiflorum, fructus aurantii, centipede, scorpio, pangolin, rhizoma dioscoreae, coix seed, polyporus umbellatus, poria, pseudo-ginseng, turtle shell, dioscorea bulbifera, momordica cochinchinensis, selfheal, edible tulip, radix sophorae subprostratae, celosia cristata, herba epimedii, fructus psoraleae, amber and red orpiment. The traditional Chinese medicine composition is capable of tonifying kidney and spleen, removing stasis, eliminating inflammation around tumors, removing tumor toxin and swelling lymph gland, better displaying the functions of various internal organs, improving immunity of the organism, self-inhibiting and eliminating tumor cells, making a local lump diminish or disappear and recovering the health status of a human body. The preparation method of the traditional Chinese medicine composition disclosed by the invention is simple to operate and suitable for industrial production.
Owner:李景宏

Triplet fluorescence quantitative detection kit for PRRSV (Porcine reproductive and respiratory syndrome virus), HP-PRRSV (Highly pathogenic porcine reproductive and respiratory syndrome virus) and CSFV (Classical Swine Fever Virus)

The invention provides a triplet fluorescence quantitative detection kit for PRRSV (Porcine reproductive and respiratory syndrome virus), HP-PRRSV (Highly pathogenic porcine reproductive and respiratory syndrome virus) and CSFV (Classical Swine Fever Virus). The triplet fluorescence quantitative detection kit comprises primers and probes listed in SEQ ID No.1-9 in a sequence table, as well as a total virus RNA extraction agent, an RT-QPCR mixed enzyme solution, RNase Free dH2O, and one or more of positive controls and negative controls. The kit is based on a triplet fluorescence quantitative PCR technology, PRRSV molecules, HP-PRRSV molecules and CSFV molecules are simultaneously detected, the kit is applied to detection of insignificant-content samples such as animal lungs, lymph glands, spleens, kidneys, hearts, livers, blood and meat products, whether the sample donors are contaminated or not is determined, and the kit is applicable to quarantine of live animals and meat products. The kit has the advantages of good specificity and high sensitivity, the detection cost is greatly lowered through joint detection, the detection time is saved, and the type of a pestilence can be conveniently determined in a short time at an epidemic outbreak.
Owner:北京联拓创盈科技有限公司 +1

Human liver cancer cell line of high lymphatic channel tranfer

The invention relates to the field of microbiological animal cells, in particular to a human hepatocarcinoma cell line with high lymph channel transfer potency established in lymph gland transfer stove, wherein nude mouse in vivo continuous screening method lymph channel transfer screening is employed to create human liver cancer cell line HCCLYM with high lymphatic channel transfer proficiency.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Medical use of engrafted nanometer carbon

The invention relates to a medical use of engrafted nanometer carbon for preparing the target medicine for lymph labeling or directly killing transferred cancer cell in the lymph gland. The engrafted nanometer carbon is produced by surface modification, connecting nanometer carbon with hydrophilic group. The engrafted nanometer carbon can be dispersed into engrafted nanometer carbon suspension in water without dispersing auxiliary and grinding scattering. The suspension has a better lymph labeling and lymph target treatment effect, and has more surface active group and connects to other chemotherapy medicine. Therefore, it is possible to exploit the engrafted nanometer carbon to the lymph target chemotherapy medicine.
Owner:SICHUAN YINGRUI PHARMA TECH CO

Test sample allergenicity detection method and kit thereof

The invention relates to a test sample allergenicity detection method and a kit thereof. The detection method comprises the following steps: randomly dividing a plurality of mice into groups; measuring the thickness of ears of each mouse of different groups; entering into a first time period; within the first time period, smear an equal amount of a reagent on the ears of each mouse of different groups; entering into a second time period; when the second time period is ended, firstly measuring the thicknesses of the ears of the mice of different groups, further killing the mice, taking down lymph glands after the ears of the mice under a sterile condition, preparing a cell suspension, putting a 5-bromodeoxyuridine solution into the cell suspension, culturing, and testing the content of the5-bromodeoxyuridine by using an ELISA (Enzyme-Linked Immuno Sorbent Assay) method; and judging the allergenicity of a test substance according to limiting standards. By adopting the method, whether the test substance has positive allergenicity can be tested, intraperitoneal injection is avoided, then animals can be prevented from pain, the amount of the 5-bromodeoxyuridine can be greatly reduced,and the detection cost can be reduced.
Owner:NANJING MEDICAL UNIV

Application of gene HES2 to auxiliary diagnosis, prognosis and treatment of esophageal squamous carcinoma

The invention discloses application of gene HES2 to the auxiliary diagnosis, prognosis and treatment of esophageal squamous carcinoma. The HES2 gene is highly expressed in esophageal squamous carcinoma tissues. The experiment further discovers that mRNA of HES2 gene is highly expressed in an esophageal squamous carcinoma cell line, the progress of the HES2 high-expressed tumor is faster and is more likely to be transferred to lymph gland or far organs, which is significantly related to poor five-year disease-free survival rate and five-year general survival rate. In addition, an antisense oligonucleotide chain sequence targeting HES2 gene is also designed to silencing HES2 expression and can be useor the trd featment of esophageal cancer. HES2 can be used as a detection marker for assisting the diagnosis of the esophageal squamous carcinoma and predicting the reoccurrence trend of the esophageal squamous carcinoma as well as a treatment target spot.
Owner:SUN YAT SEN UNIV CANCER CENT +1

Mucosal adjuvant and its preparation method and use

The invention provides a mucosal adjuvant. The mucosal adjuvant is prepared by copolymerization crosslinking compounding of oligo-chitosan and lymphotactin encoding plasmids. The invention also discloses a preparation method and a use of the mucosal adjuvant. When the mucosal adjuvant and a gene vaccine composed of chitosan or oligo-chitosan are synchronously dropped into a nasal cavity for immunization, coxsackievirus specific serum antibody and systemic (spleen and lymph glands) Th1-type immune responses are induced and especially, intestinal mucosa partially-reinforced specific-secretion-type sIgA and IFNgama+Th1 responses are induced, and thus a gene vaccine used with the mucosal adjuvant is obviously superior to an exposed gene vaccine and effectively prevents coxsackievirus-caused myocarditis. The mucosal adjuvant can be used as a novel mucosal vaccination adjuvant.
Owner:FUDAN UNIV

Positioning and marking system for finding lymph glands

The invention belongs to the technical field of pathological apparatus and discloses a positioning and marking system for finding lymph glands. The positioning and marking system for finding lymph glands solves the technical problems that the prior art depends on hands of the pathologist to find lymph glands, the finding time is long, the lymph gland number is insufficient, and the small lymph glands are easy to be neglected. According to the technical scheme, the positioning and marking system for finding lymph glands comprises an ultrasonic detecting device body, an imaging device, a probe, a positioning and marking device, an automatic identifying device, a mode selecting device, a wireless power supply receiving device, and an assorted wireless power supply emitting device connected with an external power supply. The positioning and marking system for finding lymph glands uses ultrasonic imaging principle and wireless design to realize observation, positioning and marking in real time, and the probe change, detecting and marking modes, observation angle regulation and positioning needle marking power can be decided according to actual situations; the positioning and marking system for finding lymph glands provides comprehensive and effective support for the later lymph gland shearing for the pathologist, has advantages of flexible use, convenience in carrying, comprehensive detection and time and labor saving, effectively reduces the workload of the pathologist and improves the working efficiency.
Owner:FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA

Yew anti-cancer paste

The invention provides a yew anti-cancer paste, which is an extract of more than ten rare traditional Chinese medicines including taxol, dragon's blood, oldenlandia diffusa and Chinese actinidia root. The external anti-cancer paste is prepared by ultrasonically crushing cytoplasm and coordinating with azone and magnetic chips. The paste has high drug loading capacity, drug factors of quantum particle peptides activate the magnetic memory of the drug factors due to the strong magnetic field function of the magnetic chips, the drug factors rapidly penetrate through the skin and enter the focus and penetrate through the cancer cells in a targeting mode, and the DNA protein chain polymerization is locked and is not depolymerized, so that the cancer cells atrophy, suicide and generate apoptosis. The paste is rapid in effect, high in air permeability, convenient and comfortable, has no toxic or side effect and constant-speed slow release, and has an extremely obvious treatment effect on cancers such as gastrointestinal carcinoma, lung cancer, breast cancer, skin cancer, nasopharynx cancer, laryngeal carcinoma, lymph gland cancer, superficial skin tumor and pancreatic cancer. The anti-cancer paste is simple in process, easy to operate, high in medicine activity and outstanding in antalgic anti-cancer effect.
Owner:林树芳
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