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Medical use of engrafted nanometer carbon

A technology of grafting nano-carbon and nano-carbon, which is applied in the field of medical use of grafted nano-carbon, and achieves the effects of convenient operation, low cost and guaranteed safety.

Active Publication Date: 2005-10-12
SICHUAN YINGRUI PHARMA TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no relevant report on the application of grafted nano-carbon in lymphatic tracing and lymphatic targeted therapy in the medical field.

Method used

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  • Medical use of engrafted nanometer carbon
  • Medical use of engrafted nanometer carbon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Purification and preparation of nano-carbon

[0030] Adopting the method disclosed in Patent Application No.: 02113731.5, Invention Name: "A Preparation Method of Nano-carbon Suspension Composition", using No. 40 carbon black as the chemical raw material, degreasing with ethyl acetate, washing with acid and alkali to reduce ash and heavy metals , and then wash off the acid and alkali with a large amount of water to make purified nano-carbon, which is used as a raw material for preparing grafted nano-carbon. Nano carbon purification preparation process steps are as follows:

[0031] 1. Ethyl acetate degreasing

[0032] Weigh 1600g of No. 40 carbon black and place it in an appropriate container, add 6000ml of ethyl acetate. Heated to reflux for 1 hour, filtered, and the filter residue was treated once more, and dried in vacuum for 2 hours to obtain 1420.59 g of crude product with a yield of 89.12%. The light transmittance of the toluene extract was 99.98%.

...

Embodiment 2

[0038] Example 2 Preparation of grafted nano-carbon

[0039] 1. Oxidative grafting reaction of nano-carbon:

[0040] Put 499.35g of nano-carbon purified by carbon black into an acid-resistant container, add 20000ml of 67% concentrated HNO 3 , heated to 100°C, and refluxed at this temperature for 100 hours.

[0041] 2. Separation and extraction of grafted nano-carbon:

[0042] After the temperature of the carbon black nitric acid solution after the reaction drops to normal temperature, centrifuge at 5600rpm for 30 minutes, move the upper black liquid into a suitable container, and evaporate under reduced pressure at a temperature of 70°C to obtain a dark brown black solid; Continue to add distilled water to the black precipitate, stir for 2 hours, and centrifuge at 5600rpm for 30 minutes. After centrifugation, the upper liquid is black, and the black precipitate is significantly reduced; move the upper black liquid into a suitable container, and evaporate under reduced pressure...

Embodiment 3

[0082] Example 3 Preparation of Grafted Nano-carbon Suspension

[0083] First, weigh 50 grams of grafted nano-carbon and put it in a glass container with a capacity of 2000ml, add 300ml of normal saline, stir for 60 minutes at room temperature, then add 300ml of normal saline, stir for 60 minutes, continue to add normal saline to 1000ml, use 10% Sodium hydroxide adjusted the pH to 6.9.

[0084]Filter the suspension with a pH value of 6.9 above through a 0.22 μm microporous membrane, either under pressure on the input side of the membrane or under negative pressure on the output side of the membrane, to remove large particles and bacteria.

[0085] Packing: 1ml / bottle. Plugging, pressing aluminum caps, leak detection, quality inspection, packaging.

[0086] The prepared grafted nano-carbon suspension has a dark brownish black color and an average particle diameter of 84nm ( Figure 7 ), pH 6.9, sterile.

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Abstract

The invention relates to a medical use of engrafted nanometer carbon for preparing the target medicine for lymph labeling or directly killing transferred cancer cell in the lymph gland. The engrafted nanometer carbon is produced by surface modification, connecting nanometer carbon with hydrophilic group. The engrafted nanometer carbon can be dispersed into engrafted nanometer carbon suspension in water without dispersing auxiliary and grinding scattering. The suspension has a better lymph labeling and lymph target treatment effect, and has more surface active group and connects to other chemotherapy medicine. Therefore, it is possible to exploit the engrafted nanometer carbon to the lymph target chemotherapy medicine.

Description

technical field [0001] The invention relates to a medical application of grafted nano-carbon, in particular to the application of grafted nano-carbon suspension in the preparation of drugs for lymphatic tracing (diagnosis) or lymphatic targeted therapy. Background technique [0002] At present, there is no targeted chemotherapy drug directly used to treat local lymphatic metastasis of malignant tumors. Lymphatic tracers used to trace the orientation and distribution of local lymph nodes of malignant tumors include technetium in the United States. 99 Isotope nanoparticles and domestic nano-carbon suspension injection. Adriamycin liposomes in North America have a certain degree of lymphatic system targeting, but after intravenous administration, they mainly accumulate in the liver and spleen, and cannot effectively reach the local drainage lymph nodes of malignant tumors. [0003] Patent No.: ZL02113731.5, Invention Name: A preparation method of a nano-carbon suspension compo...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K9/14A61K33/44A61K49/00A61P35/00
Inventor 唐小海邱宇
Owner SICHUAN YINGRUI PHARMA TECH CO
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