The present invention discloses a quality control method of asthma tablets, which includes the flowing steps: (1) chromatography conditions and system suitability experiment; (2) preparation of control solution; (3) preparation of test solution is as following: taking the product, removing the coating, porphyrizing, taking about 1g, placing into a 50ml volumetric flask, adding 1ml of ammonia testsolution and 25ml of chloroform precisely, weighing the weight, carrying out the ultrasonic treatment with the power of 260w and the frequency of 40KHz for 30 minutes, cooling, weighing the weight, using the chloroform to supplement the loss weight, shaking evenly, filtering, sucking 5ml of filtrate precisely, adding 2ml of 2 percent hydrochloric ethanol anhydrous, shaking evenly, drying up by evaporation in a water bath, adding 10ml of 0.1percent hydrochloric acid in the residual slag, full dissolving by ultrasound, filtering, and taking the subsequent filtrate; (4) weigh and suck the controlsolution and the test solution precisely and respectively to inject to an HPLC instrument for determination. The method adopts the HPLC to carry out the content determination of morphine, codeine phosphate and ephedrine hydrochloride in the prescription under a same system, which can not only ensure the efficacy of the products, but can also enable the quality of the products to be stable.