The invention discloses an application of 3,5,4'-trihydroxy-stilbyl-3'-O-
glucoside in the preparation of microcirculatory disturbance improvement medicines. The microcirculatory disturbance improvement medicines comprise 3,5,4'-trihydroxy-stilbyl-3'-O-
glucoside as an effective
active component, and one or more pharmaceutically acceptable auxiliary agents, especially
gastrodin and / or water-soluble
cyclodextrin derivatives and PEG400 and
mannitol, wherein the
structural formula of 3,5,4'-trihydroxy-stilbyl-3'-O-
glucoside is shown in the specification. The microcirculatory disturbance improvement medicines treat 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside as the effective
active component, and are used for improving disturbances caused by cerebral microvascular damages and / or disturbances caused by
ischemia reperfusion damages and / or disturbances caused by leukocyte adhesion damages, and / or disturbances caused by peroxides. Normal mice of Kunming species and artificially induced microcirculatory disturbance model mice undergo
tail vein injection treatment, and results of the observation of
arteriole and venule
systole and
capillary network under a microcirculatory
microscope show that 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside has an obvious expansion effect on the blood vessels of the normal mice, can obviously
resist the reduction of the
arteriole and venule
systole and
capillary network opening number of the microcirculatory disturbance model mice and can obviously
resist the reduction of the
blood flow speed.