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Incarvillea younghusbandii phenylpropanoid glycoside composition and preparation and use thereof

A kind of technology of fennel anthocyanin and Zangboluo flower, which is applied in the field of Zangboluo anthocyanin composition and its preparation and application, and can solve the problems of carcinogenicity, toxicity, teratogenicity, etc.

Inactive Publication Date: 2008-09-17
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditionally synthesized antioxidants have relatively strong antioxidant capacity, long-term consumption has potential toxicity, and some may even cause teratogenic and carcinogenic effects, so they are increasingly rejected by people.

Method used

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  • Incarvillea younghusbandii phenylpropanoid glycoside composition and preparation and use thereof
  • Incarvillea younghusbandii phenylpropanoid glycoside composition and preparation and use thereof
  • Incarvillea younghusbandii phenylpropanoid glycoside composition and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0072] Example 1.1 Preparation of Zangboluo flower total phenylpropanoid glycosides (abbreviated ZZBG) (using the first method)

[0073] Take Zangboluo medicinal material with a crushed fineness of 100 meshes, and extract it with water, wherein the weight / capacity ratio of Zangboluo pulverized product to solvent is 1:20, mix the Zangboluo pulverized product mixed in proportion with the above-mentioned The solvent is placed in the extraction kettle, the extraction temperature is 80°C, and the extract is concentrated (pressure 98Kpa, temperature 80°C) to obtain the corresponding water extraction concentrate, which is chromatographed with a 60-100 mesh polyamide column and washed with an ethanol aqueous solution gradient. The ethanol solution with a concentration > 60% was collected to obtain a composition mainly containing Tibetan glycoside A and Tibetan glycoside A; it was further purified by adsorption on a 40-80 mesh silica gel column, and then rinsed with 20% ethanol to remov...

Embodiment 12

[0074] The preparation of embodiment 1.2 total phenylpropanoid glycosides of Zangboluo flower (using the first method)

[0075]Take Zangboluo medicinal material with a crushed fineness of 200 meshes, extract with 30% ethanol solvent, wherein the weight / capacity ratio of Zangboluo pulverized matter and solvent is 1:20, and mix Zangboluo in proportion Put the crushed flower and the above solvent in the extraction kettle, the extraction temperature is 50°C, and the extract is concentrated to obtain the corresponding alcohol solvent extraction concentrate, which is chromatographed with HPD-100 macroporous adsorption resin column, and gradient eluted with methanol aqueous solution , collect the eluting part of the aqueous methanol solution with a concentration > 60%, and obtain a composition mainly containing Tibetan glycoside A and Tibetan glycoside A; it is further purified by adsorption on a 60-100 mesh silica gel column, rinsed with 20% ethanol to remove impurities, and then Us...

Embodiment 13

[0076] The preparation of embodiment 1.3 total phenylpropanoid glycosides of Zangboluo flower (using the first method)

[0077] Take Zangboluo medicinal material with a crushed fineness of 40 meshes, extract with 90% ethanol solvent, wherein the weight / capacity ratio of Zangboluo pulverized matter and solvent is 1:2, and mix Zangboluo in proportion The crushed flower and the above solvent are placed in an extraction kettle, the extraction temperature is 50°C, and the extract is concentrated to obtain the corresponding water extraction concentrate, which is chromatographed with HPD-400 macroporous adsorption resin and eluted with a gradient of propanol aqueous solution. Collect the eluted part of the propanol aqueous solution whose concentration is > 60%, and obtain the composition mainly containing Tibetan glycoside A and Tibetan glycoside A; further refine through adsorption on a 200-300 mesh silica gel column, rinse with 20% ethanol to remove impurities, and then Elute with ...

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Abstract

The invention relates to a phenylpropanoid glycosides composition extracted from traditional tibetan medicine incarvillea younghusnandii and a preparation method, comprising an incarvillea younghusnandii phenylpropanoid glycosides compound A and an incarvillea younghusnandii phenylpropanoid glycosides compound B, wherein, the weight ratio of the compound A and the compound B is 60 to 90 : 40 to 10; and the total content of two compounds is 70% to 100% of the total weight of the phenylpropanoid glycosides. The phenylpropanoid glycosides composition is characterized in that: when the composition is used as an anti-oxygenic medicine or health care product, the composition can be used for treating the disease caused by damaging the related free radicals such as aging, atherosclerosis and ischemia-reperfusion injury; and when the composition is used as the antioxidant additive for the food and the forage, the composition can be used for protecting or alleviating the forage from rancidity and metamorphosis, the nutritive value from decreasing and the palatability from variation. The phenylpropanoid glycosides composition has the advantages that: the preparation prepared with the composition as main component can be tablet, capsule, granule, injection, dropping pill, liquid preparation and powder; and the new plant natural antioxidant with nature, efficiency and low toxicity is provided.

Description

technical field [0001] The present invention relates to natural medicine compound and its preparation method and application. It specifically relates to the total phenylpropanoid glycoside composition extracted from the traditional Tibetan medicine Zangboluo flower and its preparation method, using this type of composition as an antioxidant drug / health product, and as an antioxidant for food and feed Use of additives. Background technique [0002] Due to the influence of environmental factors, dietary factors, and life factors, the metabolism of free radicals in the modern human body is often easily out of balance. The balance of the generation and removal of free radicals is very important for the normal process of life. Only when the generation and removal of oxygen free radicals are in balance can the body maintain health. Too many free radicals or insufficient scavenging ability, there are excess free radicals in the body, causing tissue damage, lipid peroxidation, enz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P39/06A23L1/30A23K1/16A23L2/52A23K20/121A23L33/105
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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