Pharmaceutical composition and application thereof
A composition and drug technology, applied in the field of medicine, can solve problems such as insufficient research
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Embodiment 1
[0181] 1.1 Preparation of myocardial infarction model
[0182] Inject pentobarbital sodium (40mg / kg) intraperitoneally, fix the rats on the operating board, and put the hair on the chest. Open the skin and bluntly separate the muscles, stretch the gap between the third and fourth ribs and fix the upper part of the heart, tear the pericardium, and hold a 5-0 suture needle with thread in the needle holder. The apex of the auricle, the conus pulmonary artery, and the junction of the auricle and the auricle were threaded and ligated. After ligation of the coronary artery, the myocardial tissue immediately turned from rosy to pale. Except that the left anterior descending coronary artery was not ligated in the sham-operated animals, the rest of the operations were identical.
[0183] 1.2 Animal grouping and administration methods
[0184] 56 rats were randomly divided into the following 7 groups: sham operation group, ischemia model group, salvianolic acid B and ginsenoside Rg1 c...
Embodiment 2
[0194] The combination of SalB / Rg1 of 5:2 and the optimal ratio of SalB / Rg1 of 2:5 disclosed in the prior art were further compared in the model of myocardial ischemia-reperfusion injury.
[0195] 2.1 Preparation of myocardial ischemia-reperfusion injury model
[0196] Pentobarbital sodium (40mg / kg) was injected intraperitoneally, the rats were fixed on the operating board, and the chest was covered with hair. Insert the pen-type intravenous indwelling needle sleeve into the trachea and connect it to the animal ventilator, disinfect with iodine, cut the skin and bluntly separate the muscles in the left 3-4 intercostal space of the chest, open the gap between the third and fourth ribs and fix them to expose In the upper part of the heart, the pericardium was torn open, and the needle holder held a 5-0 suture needle with thread. With the left coronary vein as the mark, the thread was threaded from the tip of the left atrial appendage, the cone of the pulmonary artery, and the ju...
Embodiment 3
[0203] SalB / Rg1(5:2) and SalB / Rg1(2:5) were further compared in the renal ischemia-reperfusion injury model.
[0204] 3.1 Preparation of renal ischemia-reperfusion injury model
[0205] Inject pentobarbital sodium (40mg / kg) intraperitoneally, fix the rats on the operating board, sterilize the abdomen with iodine wine, incision 2.5cm in the middle of the abdomen, separate the intestinal tract to expose the left kidney, separate the fat around the kidney, and clip the artery The left renal pedicle (including renal artery, renal vein, and renal pelvis) was clamped for 40 minutes to cause renal ischemia, and the right and left kidneys were operated in the same way. After 40 minutes, the arterial clips on the left and right kidneys were removed. After 24 hours, the kidneys were injured by ischemia and reperfusion, and the muscles and skin were sutured. Except that the renal pedicles on both sides were not clipped, the other surgical operations were the same for the sham-operated a...
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