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Pharmaceutical composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as insufficient research

Pending Publication Date: 2021-03-05
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the compatible use of the two is not enough, and it is necessary to carry out further in-depth research on the compatibility of prescriptions, so as to provide a pharmaceutical composition with curative effect on ischemia-reperfusion injury of different tissues and organs

Method used

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  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof
  • Pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] 1.1 Preparation of myocardial infarction model

[0182] Inject pentobarbital sodium (40mg / kg) intraperitoneally, fix the rats on the operating board, and put the hair on the chest. Open the skin and bluntly separate the muscles, stretch the gap between the third and fourth ribs and fix the upper part of the heart, tear the pericardium, and hold a 5-0 suture needle with thread in the needle holder. The apex of the auricle, the conus pulmonary artery, and the junction of the auricle and the auricle were threaded and ligated. After ligation of the coronary artery, the myocardial tissue immediately turned from rosy to pale. Except that the left anterior descending coronary artery was not ligated in the sham-operated animals, the rest of the operations were identical.

[0183] 1.2 Animal grouping and administration methods

[0184] 56 rats were randomly divided into the following 7 groups: sham operation group, ischemia model group, salvianolic acid B and ginsenoside Rg1 c...

Embodiment 2

[0194] The combination of SalB / Rg1 of 5:2 and the optimal ratio of SalB / Rg1 of 2:5 disclosed in the prior art were further compared in the model of myocardial ischemia-reperfusion injury.

[0195] 2.1 Preparation of myocardial ischemia-reperfusion injury model

[0196] Pentobarbital sodium (40mg / kg) was injected intraperitoneally, the rats were fixed on the operating board, and the chest was covered with hair. Insert the pen-type intravenous indwelling needle sleeve into the trachea and connect it to the animal ventilator, disinfect with iodine, cut the skin and bluntly separate the muscles in the left 3-4 intercostal space of the chest, open the gap between the third and fourth ribs and fix them to expose In the upper part of the heart, the pericardium was torn open, and the needle holder held a 5-0 suture needle with thread. With the left coronary vein as the mark, the thread was threaded from the tip of the left atrial appendage, the cone of the pulmonary artery, and the ju...

Embodiment 3

[0203] SalB / Rg1(5:2) and SalB / Rg1(2:5) were further compared in the renal ischemia-reperfusion injury model.

[0204] 3.1 Preparation of renal ischemia-reperfusion injury model

[0205] Inject pentobarbital sodium (40mg / kg) intraperitoneally, fix the rats on the operating board, sterilize the abdomen with iodine wine, incision 2.5cm in the middle of the abdomen, separate the intestinal tract to expose the left kidney, separate the fat around the kidney, and clip the artery The left renal pedicle (including renal artery, renal vein, and renal pelvis) was clamped for 40 minutes to cause renal ischemia, and the right and left kidneys were operated in the same way. After 40 minutes, the arterial clips on the left and right kidneys were removed. After 24 hours, the kidneys were injured by ischemia and reperfusion, and the muscles and skin were sutured. Except that the renal pedicles on both sides were not clipped, the other surgical operations were the same for the sham-operated a...

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Abstract

The invention provides a pharmaceutical composition and application thereof. Specifically, the pharmaceutical composition comprises salvianolic acid B as a first active ingredient and ginsenoside Rg1as a second active ingredient, wherein the weight ratio of the first active ingredient to the second active ingredient is 5: (1-4.5). The pharmaceutical composition has a better active ingredient ratio than the prior art, has a more excellent curative effect in the aspects of preventing and / or treating ischemic diseases and ischemia-reperfusion tissue and organ injuries, and can be used for treating ischemia and / or ischemia-reperfusion injuries of different tissues and organs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition and its application in preventing and / or treating ischemic diseases and / or ischemia-reperfusion injuries and other diseases. Background technique [0002] Blood vessels are responsible for supplying blood to the tissues and organs of the whole body. Once the blood vessels are blocked, the tissues and organs will suffer from insufficient blood supply and cause diseases, especially the tissues and organs that have a high demand for blood oxygen supply such as the heart and brain; The establishment and popularization of spasm relief, arterial bypass surgery, thrombolytic therapy, percutaneous transluminal coronary angioplasty, extracorporeal circulation in cardiac surgery, cardiopulmonary cerebral resuscitation, replantation of severed limbs and organ transplantation have made many tissues and organs Blood supply can be restored after ischemia (ie, reperfusion). ...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K31/704A61P9/10
CPCA61K31/343A61K31/704A61P9/10A61K2300/00A61P9/04A61P9/00A61K36/258A61K36/537A61K9/10A61K9/19A61K9/4808A61K31/216
Inventor 姜宝红王琳琳王小玉付瑶边慧淼邢蓉蓉
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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