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67 results about "Hif prolyl hydroxylase" patented technology
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HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors . Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond...
Prolyl Hydroxylase Inhibitors
The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:SMITHKLINE BECKMAN CORP
Prolyl Hydroxylase Inhibitors
Owner:GLAXO SMITHKLINE LLC
N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors
The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:SMITHKLINE BECKMAN CORP
Substituted 4-Hydroxypyrimidine-5-Carboxamides
ActiveUS20090239876A1Increase productionReduce productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
N-Substituted Glycine Derivatives: Hydroxylase Inhibitors
The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Prolyl hydroxylase inhibitors
The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Prolyl hydroxylase inhibitors
Owner:GLAXO SMITHKLINE LLC
Prolyl hydroxylase inhibitors
The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:SMITHKLINE BECKMAN CORP
Spiroindalones
ActiveUS20100137297A1Increase productionReduce productionBiocideOrganic chemistryHif prolyl hydroxylaseProlyl Hydroxylases
The present invention relates to spiroindalone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Spiroazaindoles
ActiveUS20110152304A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to spiroazaindole compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Prolyl Hydroxylase Inhibitors
The invention described herein relates to certain quinoxaline-5-carboxamide derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Novel 1,8-naphthyridine compounds
The present invention relates to naphthyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK & CO INC
Novel 1.8-naphthyridine compounds
InactiveUS20100056563A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesHif prolyl hydroxylase
The present invention relates to naphthyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME CORP
N-substituted glycine derivatives: hydroxylase inhibitors
The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Tetrahydrofuropyridones
The present invention relates to Tetrahydrofuropyridones compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Prolyl Hydroxylase Inhibitors
InactiveUS20110160227A1Increase productionOrganic active ingredientsBiocideDiseaseProlyl Hydroxylases
The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:SHAW ANTONY +1
Prolyl hydroxylase inhibitors
The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Substituted pyrimidines
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:BIODURO BAONUO TECH BEIJING CO LTD +1
Prolyl Hydroxylase Inhibitors
InactiveUS20100298324A1Increase productionBiocideOrganic active ingredientsDiseaseHif prolyl hydroxylase
The invention described herein relates to certain 4-oxo-2-thioxo-1,2,3,4-tetrahydro-7-quinazolinecarboxamide derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Substituted pyrimidines
The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC +2
Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones
InactiveCN102459278AEnhance endogenous productionReduce anemiaOrganic chemistryMetabolism disorderHif prolyl hydroxylaseProlyl Hydroxylases
The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/117202DEST_PATH_IMAGE071.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/12039DEST_PATH_IMAGE044.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
![Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/431918bd-efbe-4456-b96e-9f1772f393f6/122449DEST_PATH_IMAGE051.PNG "Substituted -1,3,8-triazaspiro[4.5]decane-2,4-diones")
Owner:SCHERING AG
Prolyl Hydroxylase Inhibitors
The invention described herein relates to certain quinoline-8-carboxamide derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITHKLINE LLC
Tetrahydro-1H-pyrrolo fused pyridones
ActiveUS8372863B2Increase productionReduce productionBiocideOrganic chemistryHif prolyl hydroxylasePyrrole
The present invention relates to tetrahydro-1H-pyrrolo fused pyridone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Prolyl hydroxylase inhibitors
Owner:GLAXO SMITHKLINE LLC
Prolyl hydroxylase inhibitors
The invention described herein relates to certain benzimidazol-4-ylcarboxamide derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Owner:GLAXO SMITH KLINE A CORP
Spiroazaindoles
Owner:MERCK SHARP & DOHME LLC
Tetrahydrofuropyridones
Owner:MERCK SHARP & DOHME LLC
Prolyl hydroxylase inhibitors
Owner:GLAXO SMITHKLINE LLC
Tetrahydro-1h-pyrrolo fused pyridones
ActiveUS20110009406A1Increased endogenous productionReduced endogenous productionBiocideOrganic chemistryProlyl HydroxylasesStereochemistry
The present invention relates to tetrahydro-1H-pyrrolo fused pyridone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
Tetrahydrothieno pyridines
ActiveUS20110009425A1Increased endogenous productionReduced endogenous productionBiocideNervous disorderPyridineHif prolyl hydroxylase
The present invention relates to tetrahydrothienopyridine compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
Owner:MERCK SHARP & DOHME LLC
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