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Application of icariin in preparation of medicine for promoting angiogenesis

A technology of icariin and angiogenesis, applied in the field of pharmacy, can solve the problem that there is no promotion of angiogenesis, etc.

Inactive Publication Date: 2013-06-19
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report of promoting angiogenesis

Method used

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  • Application of icariin in preparation of medicine for promoting angiogenesis
  • Application of icariin in preparation of medicine for promoting angiogenesis
  • Application of icariin in preparation of medicine for promoting angiogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 of the present invention: get 5 g of icariin, 75 g of medicinal starch, and 20 g of microcrystalline cellulose, dry the medicinal starch first, pass through a 120 mesh sieve, and then mix with icariin and microcrystalline cellulose Mix, pass twice 120 mesh sieves, fill in the hard capsule, make 1000 capsules of the present invention. Each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0037] Embodiment 2 of the present invention: icariin 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, magnesium stearate 1g; After mixing, put it into a high-speed blender, spray and add appropriate amount of water, granulate, control the water content at 3~4%, and then compress into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0038] Example 3 of the present invention: Add 5 g of icariin, add 400 ml of polyethylene glycol 200 to dissolve, then add an appropriate amount of distilled water to dilute, then add an appropriate amount of sucrose and adjust the volume to 1000 ml, stir well, filter, and fill into 10 ml or 20 ml each, sterile packaged.

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Abstract

The invention discloses an application of icariin in preparation of a medicine for promoting angiogenesis. The icariin is used for preparing the medicine for promoting angiogenesis. Animal experimental verification proves that the prepared medicine composition can be used for preventing and treating ischemic injuries including perpetual ischemic injuries and ischemia-reperfusion injuries of limbs and intestinal tracts (small intestines and large intestines). The icariin has the advantages of being wide in source of raw materials, easy to obtain, simple and practical in preparation of the medicine and having a good curative effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of icariin in the preparation of drugs for promoting angiogenesis. Background technique [0002] Limb ischemia is defined as sudden reduction in limb perfusion due to any etiology and potentially compromising limb vitality. Compared with chronic critical limb ischemia, the duration of acute limb ischemia should not exceed 2 weeks. There are many causes of limb ischemia, including reconstruction / graft thrombosis, embolism, autologous arterial thrombosis, peripheral aneurysm wall thrombus detachment / thrombosis, trauma (including iatrogenic), among which graft thrombosis is Most common cause of acute limb ischemia. The intensity of symptoms is related to the etiology. The causes of sudden severe pain in the early stage (within a few hours) are embolism, peripheral aneurysm wall thrombus detachment / thrombosis, and trauma; the most common causes are symptoms in the later stag...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
Inventor 龚其海李菲石京山
Owner ZUNYI MEDICAL UNIVERSITY
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