Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof

An ischemia-reperfusion, ACY-1 technology, applied in the field of aminoacylase aminoacylase-1 and aminoacylase-1 diagnosis and prognosis, can solve the problem of lack of candidate markers with clear clinical utility and other problems

Inactive Publication Date: 2015-11-11
UNIV OF LEEDS
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many candidates for biomarkers in IRI, and promising markers such as NGAL and IL-18 studied so far, no candidate markers with clear clinical utility have emerged

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof
  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof
  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The inventors employed immunoknockdown of the 14 most abundant proteins in combination with the high-mass precision LTQ-OrbitrapVelos (double-partition linear trap and electrostatic field orbitrap combined high-resolution mass spectrometry) label-free analysis 21 Whereas serum proteins were compared pre- and post-operatively in patients undergoing renal transplantation (with and without DGF). The inventors surprisingly identified a key candidate as aminoacylase-1 (ACY-1). With the development of assay technology, for the first time, serum ACY-1 could be measured and validated in a larger cohort of patients, thereby identifying ACY-1 as a marker for IRI and DGF in samples as early as day 1 post-transplantation potential clinical utility, and importantly a significant correlation with outcome was observed.

[0044] Furthermore, the identification of serum-based biomarkers and the use of serum has clear advantages in the case of IRI and especially in the case of DGF. Pa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to use of ACY-1 as a biomarker for ischaemia-reperfusion injury.

Description

technical field [0001] The present invention relates to biomarkers for ischemia-reperfusion injury or delayed graft function. In particular the present invention relates to the aminoacylase aminoacylase-1 and methods of diagnosis and prognosis using the aminoacylase-1. Background technique [0002] with dialysis 3,4 Compared with kidney transplantation for end-stage renal disease 1,2 There are clear benefits for patients and significant cost savings. In 2010, 16,151 kidney transplants were performed in the US (http: / / optn.transplant.hras.gov) and the corresponding figure in the UK was 2,687 (http: / / www.uktransplant.org.uk). However, a proportion of patients develop early complications such as delayed graft function (DGF) 5 , these early complications can significantly impact clinical and health economic outcomes. [0003] Various definitions of DGF have been proposed 6-8 , the commonly used one requires dialysis in addition to isolation of hyperkalemia during the first...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCC12N9/80C12Q1/6883C12Q2600/118C12Q2600/158G01N33/573G01N33/6893G01N2800/245G01N2800/324G01N2800/7019C12Q1/34G01N2333/98
Inventor R·E·班克斯M·P·W·史密斯P·J·塞尔比A·莱温顿
Owner UNIV OF LEEDS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com