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Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof

An ischemia-reperfusion, ACY-1 technology, applied in the field of aminoacylase aminoacylase-1 and aminoacylase-1 diagnosis and prognosis, can solve the problem of lack of candidate markers with clear clinical utility and other problems

Inactive Publication Date: 2015-11-11
UNIV OF LEEDS
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Problems solved by technology

Although there are many candidates for biomarkers in IRI, and promising markers such as NGAL and IL-18 studied so far, no candidate markers with clear clinical utility have emerged

Method used

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  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof
  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof
  • Use of ACY-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof

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Embodiment Construction

[0043] The inventors employed immunoknockdown of the 14 most abundant proteins in combination with the high-mass precision LTQ-OrbitrapVelos (double-partition linear trap and electrostatic field orbitrap combined high-resolution mass spectrometry) label-free analysis 21 Whereas serum proteins were compared pre- and post-operatively in patients undergoing renal transplantation (with and without DGF). The inventors surprisingly identified a key candidate as aminoacylase-1 (ACY-1). With the development of assay technology, for the first time, serum ACY-1 could be measured and validated in a larger cohort of patients, thereby identifying ACY-1 as a marker for IRI and DGF in samples as early as day 1 post-transplantation potential clinical utility, and importantly a significant correlation with outcome was observed.

[0044] Furthermore, the identification of serum-based biomarkers and the use of serum has clear advantages in the case of IRI and especially in the case of DGF. Pa...

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Abstract

The invention relates to use of ACY-1 as a biomarker for ischaemia-reperfusion injury.

Description

technical field [0001] The present invention relates to biomarkers for ischemia-reperfusion injury or delayed graft function. In particular the present invention relates to the aminoacylase aminoacylase-1 and methods of diagnosis and prognosis using the aminoacylase-1. Background technique [0002] with dialysis 3,4 Compared with kidney transplantation for end-stage renal disease 1,2 There are clear benefits for patients and significant cost savings. In 2010, 16,151 kidney transplants were performed in the US (http: / / optn.transplant.hras.gov) and the corresponding figure in the UK was 2,687 (http: / / www.uktransplant.org.uk). However, a proportion of patients develop early complications such as delayed graft function (DGF) 5 , these early complications can significantly impact clinical and health economic outcomes. [0003] Various definitions of DGF have been proposed 6-8 , the commonly used one requires dialysis in addition to isolation of hyperkalemia during the first...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCC12N9/80C12Q1/6883C12Q2600/118C12Q2600/158G01N33/573G01N33/6893G01N2800/245G01N2800/324G01N2800/7019C12Q1/34G01N2333/98
Inventor R·E·班克斯M·P·W·史密斯P·J·塞尔比A·莱温顿
Owner UNIV OF LEEDS
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