The invention discloses a mixed extract of Speranthema fragrans and Arborvitae leaves, which comprises the following components: pinene, 2-carene, limonene, clovene, terpineyl acetate, phellandrene, palmitic acid, ethyl palmitate Esters, 1-methoxybutane, 5,6,7,7A-tetrahydro-2(4H)-benzofuranone, 6,10,14-trimethyl-2-pentadecanone, hexadecanoic acid methyl esters and dibutyl phthalate. The invention is mainly applicable to the treatment of androgenetic alopecia, tinea pedis, tinea manuum, tinea corporis and other dermatophytosis. The traditional Chinese medicines, cypress arborvitae and sarcocarpus, are commonly used clinical medicines, are cheap, easy to obtain, high in safety factor, and can be taken orally or applied externally. The invention is simple to use, and the extraction does not require excessive technical requirements. The extract can effectively remove the impurities of conventional traditional Chinese medicines, purify the precision of medicines, clarify the functional components, make reasonable compatibility, simplify the use process, and ensure the uniform quality of medicines.