Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A method for distinguishing natural musk and artificial musk

A technology of artificial musk and natural musk, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of long separation time, long processing time, high toxicity, etc., and achieve the effects of low fluid viscosity, short running time and low cost

Active Publication Date: 2015-09-30
BEIJING UNIV OF CHINESE MEDICINE +1
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Liang Ying and Wang Xiaogen (preliminary analysis of natural musk and artificial musk by GC-MS method, "New Drugs and Clinical Pharmacology of Traditional Chinese Medicine", 2005, Volume 16, No. 3, p204-205) reported that musk pyridine, 3-methylcyclo Tridecone is used as a specific ingredient, and the GC-MS method is used to identify natural musk and artificial musk. This method can accurately identify natural musk and artificial musk, but there are the following deficiencies: the extraction reagent uses benzene, which is highly toxic; the pretreatment time of the test product Long, more than 1.5h; long separation time, the retention time of specific components is more than 20min
[0006] Zhou Jian et al. (Using infrared spectroscopy to identify the authenticity of traditional Chinese medicine musk, Spectroscopy and Spectral Analysis, 2010, Volume 30, No. 9, p2368-2371) reported the use of Fourier transform-infrared spectroscopy (FTR-IR) Research on natural musk and artificial musk, found that the infrared spectra of the two are very similar, have common absorption peaks and most of the intensity is consistent, it is difficult to identify; although using the comparison and analysis of the second order derivative spectrum, it is found Musk has differences in some peaks, but the differences are small and it is difficult to distinguish the two definitely

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for distinguishing natural musk and artificial musk
  • A method for distinguishing natural musk and artificial musk
  • A method for distinguishing natural musk and artificial musk

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The identification method of embodiment 1 natural musk and artificial musk

[0051] 1. Preparation of mixed reference solution:

[0052] Precisely weigh 0.5 mg of the reference substance of hexacanoic acid and 0.5 mg of the reference substance of octacosanoic acid, put them in a 50 mL volumetric flask, add n-hexane solvent to dissolve, and constant volume to obtain the product.

[0053] 2. Preparation of the test solution:

[0054] Accurately weigh about 0.05 g of the musk sample to be tested, place it in a conical flask, add 10 mL of ethyl acetate, ultrasonicate for 10 min, and filter to obtain the product.

[0055] 3. Test method:

[0056] Take the mixed reference substance solution and the test solution respectively, inject them into the ultra-high performance convergence chromatography tandem mass spectrometer, and obtain the total ion chromatogram of the reference solution and the total ion of the test solution according to the following ultra-high performance co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for identifying natural musk and muskone. The method comprises the following step: with hexacosanoic acid and octacosanoic acid as reference substances, performing qualitative identification by adopting an ultrahigh performance bonded-phase chromatography-tandem mass spectrometry method. The method disclosed by the invention is used for identifying the natural musk and the muskone; a sample is simple in pretreatment, and rapid, accurate, and environmentally friendly in detection.

Description

technical field [0001] The invention belongs to the field of drug analysis, in particular to a method for identifying natural musk and artificial musk. Background technique [0002] Natural musk (Moschus) is a precious and rare Chinese medicinal material. It is the dry secretion in the mature male sachet of the deer animal Moschus berezovskii Flerov, Moschus sifanicus Przewalski or the original musk deer Moschus moschiferus Linnaeus. The musk deer is a first-class protected wild animal in the country. The source and output of natural musk are very limited, and most of the current clinical use is artificial musk. [0003] Artificial musk is a national first-class new drug developed according to the chemical components of natural musk. The types and contents of its chemical components are very similar to those of natural musk. . Compared with artificial musk, natural musk also contains many unknown trace components, and some of these trace components themselves have biologic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/88
Inventor 马群解素花乔延江顾海鸥杜菁刘永刚
Owner BEIJING UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com