A kind of mixed extract of Sperancis fragrans and Arborvitae leaves and its extraction process and application

Abstract

The invention discloses a mixed extract of Speranthema fragrans and Arborvitae leaves, which comprises the following components: pinene, 2-carene, limonene, clovene, terpineyl acetate, phellandrene, palmitic acid, ethyl palmitate Esters, 1-methoxybutane, 5,6,7,7A-tetrahydro-2(4H)-benzofuranone, 6,10,14-trimethyl-2-pentadecanone, hexadecanoic acid methyl esters and dibutyl phthalate. The invention is mainly applicable to the treatment of androgenetic alopecia, tinea pedis, tinea manuum, tinea corporis and other dermatophytosis. The traditional Chinese medicines, cypress arborvitae and sarcocarpus, are commonly used clinical medicines, are cheap, easy to obtain, high in safety factor, and can be taken orally or applied externally. The invention is simple to use, and the extraction does not require excessive technical requirements. The extract can effectively remove the impurities of conventional traditional Chinese medicines, purify the precision of medicines, clarify the functional components, make reasonable compatibility, simplify the use process, and ensure the uniform quality of medicines.

Description

technical field [0001] The invention relates to the technical field of medicine, and in particular relates to a mixed extract of Otonia orientalis and oriental orientalis leaves and an extraction process and application thereof. Background technique [0002] Androgenetic alopecia, also known as seborrheic alopecia, male pattern baldness, is a male hormone-dependent polygenic hereditary disease. At present, the incidence of androgenetic alopecia in Han Chinese men is as high as 21.3%, and the prevalence in women is 6.0%. %, which greatly affects the appearance of patients, easily leads to increased psychological burden on patients, and affects the quality of daily life. [0003] At present, there is no specific treatment for androgenetic alopecia in clinical practice, mainly oral finasteride, dutasteride, AR antagonists (cyproterone acetate, flutamide, bicalutamide, BMS-641988 and MDV3100, etc.), externally coated with minoxidil, RU58841, antifungal drugs (selenium disulfide...

AI Technical Summary

Problems solved by technology

[0014] (1) Conventional androgenetic alopecia drugs, such as topical minoxidil or oral finasteride tablets, have certain side effects, such as local skin contact dermatitis-like lesions, increased dandruff, or male sexual dysfunction, etc. Adverse reactions, and the drug takes effect slowly (at least 6 months of treatment), easy to relapse after stopping the drug

Although new androgenetic alopecia treatments such as minimally invasive hair transplantation (FUE), low-energy laser irradiation (LLLT), and local injection of platelet-rich plasma have certain curative effects, they are expensive and cumbersome to use (frequent trips to and from medical institutions are required). Or there are obvious trauma and other deficiencies, it is difficult to promote

[0015] (2) Although dermatophytosis such as tinea pedis, tinea manuum, and tinea corporis has been thoroughly studied and curative effects are clear, with the widespread use of antibiotics, the drug-resistant rate of fungal strains has increased year by year, and the antibacterial properties of drugs have decreased, making this disease The curative effect of the treatment is decreasing day by day (for example, miconazole nitrate (Dactin) has been difficult to achieve satisfactory therapeutic effect in recent years), so multiple broad-spectrum antibacterial drugs are used in combination at present

However, the long-term combined use of multiple broad-spectrum antibacterial drugs is also more likely to cultivate super-resistant bacteria, which leads to a vicious circle, and there is a risk of no drug available in the future

[0016] (3) Eczema is a common disease with a high incidence and easy recurrence

However, the use of traditional Chinese medicine is too cumbersome and needs to be decocted. There are problems such as different operation methods, different origins and quality of Chinese medicinal materials, and more impurities in the drug. With the increase in the price of medicinal materials, the cost of using traditional Chinese medicine is also increasing. The economic burden of

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