Herba speranskiae tuberculatae and cacumen platycladi mixed extract and extraction process and application thereof

Abstract

The invention discloses a herba speranskiae tuberculatae and cacumen platycladi mixed extract. The mixed extract comprises pinene, 2-carene, limonene, trans-caryophyllene, terpinyl acetate, phellandrene, palmitic acid, ethyl palmitate, 1-methoxy butane, 5,6,7,7A-tetrahydro-2(4H)-benzofuranone, 6,10,14-trimethyl-2-pentadecanone, methyl hexadecanoate and dibutyl phthalate. The herba speranskiae tuberculatae and cacumen platycladi mixed extract is mainly applicable to treatment of androgenetic alopecia and dermatomycosis such as tinea pedis, tinea manuum and tinea corporis. Herba speranskiae tuberculatae and cacumen platycladi are both clinical common medicines and are cheap, convenient to acquire, high in safety coefficient and available for oral administration and external application. Theextract is simple in use, high technical requirements on extraction are avoided, conventional traditional Chinese medicine impurities can be effectively removed, medicine purity is improved, extract effective components and reasonable compatibility are realized, a utilization process is simplified, and medicine quality uniformity is guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a mixed extract of Sperantosporum and Arborvitae leaves and its extraction process and application. Background technique [0002] Androgenetic alopecia, also known as seborrheic alopecia and male pattern alopecia, is a polygenic hereditary disease dependent on androgen. At present, the incidence of androgenetic alopecia is as high as 21.3% in males and 6.0% in females. %, which greatly affects the appearance of the patient, easily leads to aggravation of the psychological burden of the patient, and affects the quality of daily life. [0003] At present, there is no specific treatment for androgenetic alopecia clinically, mainly oral finasteride, dutasteride, AR antagonists (cyproterone acetate, flutamide, bicalutamide, BMS-641988 and MDV3100, etc.), topical application of minoxidil, RU58841, antifungal drugs (selenium disulfide lotion, 2% ketoconazole lotion, etc.) and 5% diene...

AI Technical Summary

Problems solved by technology

[0014] (1) Conventional androgenetic alopecia drugs, such as topical minoxidil or oral finasteride tablets, have certain side effects, such as local skin contact dermatitis-like lesions, increased dandruff, or male sexual dysfunction, etc. Adverse reactions, and the drug takes effect slowly (at least 6 months of treatment), easy to relapse after stopping the drug

Although new androgenetic alopecia treatments such as minimally invasive hair transplantation (FUE), low-energy laser irradiation (LLLT), and local injection of platelet-rich plasma have certain curative effects, they are expensive and cumbersome to use (frequent trips to and from medical institutions are required). Or there are obvious trauma and other deficiencies, it is difficult to promote

[0015] (2) Although dermatophytosis such as tinea pedis, tinea manuum, and tinea corporis has been thoroughly studied and curative effects are clear, with the widespread use of antibiotics, the drug-resistant rate of fungal strains has increased year by year, and the antibacterial properties of drugs have decreased, making this disease The curative effect of the treatment is decreasing day by day (for example, miconazole nitrate (Dactin) has been difficult to achieve satisfactory therapeutic effect in recent years), so multiple broad-spectrum antibacterial drugs are used in combination at present

However, the long-term combined use of multiple broad-spectrum antibacterial drugs is also more likely to cultivate super-resistant bacteria, which leads to a vicious circle, and there is a risk of no drug available in the future

[0016] (3) Eczema is a common disease with a high incidence and easy recurrence

However, the use of traditional Chinese medicine is too cumbersome and needs to be decocted. There are problems such as different operation methods, different origins and quality of Chinese medicinal materials, and more impurities in the drug. With the increase in the price of medicinal materials, the cost of using traditional Chinese medicine is also increasing. The economic burden of

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