The invention discloses a cold-accumulation type refrigerant and a cold-accumulation type cold compress bag. The refrigerant comprises the following components in percentage by weight: 30-40% of urea, 6-12% of ammonium chloride, 6-12% of potassium nitrate, 2-5% of guar and 35-45% of water. The cold compress bag comprises an outer bag, wherein solid materials comprising the refrigerant and water are arranged in the outer bag, and a sealing strip is arranged in the outer bag to separate the solid materials from the water. The refrigerant disclosed by the invention comprises three refrigerants, the solution heat of the cold compress bag is increased by various refrigerants, and the cold compress effect is better. Because the macromolecule edible-grade guar gum is added in refrigerant particles, the cold compress time of the cold-accumulation type cold compress bag disclosed by the invention is 2-3 times longer than the traditional common cold-accumulation type cold compress bag, so that the whole system is in a colloid shape and is unlikely to flow, and the use comfort level of a patient is improved. The solid materials and the water are separated by the sealing strip, and the cold compress bag is convenient to use; and in the transportation process, the solid materials and the water can be effectively separated and cannot be mixed, which is convenient for transporting the cold compress bag.