A valve
assembly is disclosed which effectively partitions a
syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing
syringe apparatus. The valve
assembly may be effectively used with a variety of standard, currently available commercial syringes and pre-filled syringes. Incorporated in the valve
assembly is a valved stopper having a valve (which may be a slit valve), an
impact sensor which opens the valve upon
impact between the valve assembly and internal distal end of the
syringe and a gas separator which separates liquid from gas disposed in the proximal chamber to assure gas is not delivered therefrom. The valve assembly is displaced as a
plunger of the syringe is displaced via communication through fluid in the proximal chamber of the syringe. The
actuator has a latching feature which latches the valve to an open state after being opened by the
impact sensor. The gas separator has a proximally disposed orifice which facilitates priming. The valve assembly may be made from two parts. One part, a valved stopper, may be molded from the same rubber based material used in syringe
plunger stoppers. The second part, the
valve actuator, may be injection molded as a single part. A synthetic resinous material which is compatible with manufacture of living hinges my be used for the second part. Multiple valve assemblies may be used in a single syringe
barrel.