Gas chromatography-mass spectrometry detection method of three very long chain fatty acids in human serum
A very long-chain fatty acid and gas chromatography technology, applied in the field of detection of very long-chain fatty acids, can solve the problems of complex, unfavorable and stable results of very long-chain fatty acids, and low extraction efficiency, so as to simplify the pretreatment process, save processing time, The effect of high extraction efficiency
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[0061] In order to make the above objects, features and advantages of the embodiments of the present invention more obvious and comprehensible, the embodiments of the present invention will be further described in detail below in conjunction with specific implementation methods.
[0062] Determination of the content of VLCFA in serum has important medical value, such as:
[0063] The abnormal accumulation of VLCFA in serum can reflect the abnormal function of enzymes involved in the VLCFAβ-oxidation process in peroxisomes, which hinders the β-oxidation of VLCFA and causes VLCFA aggregation. The accumulation of VLCFA in the nervous system can destroy the normal formation of myelin sheath and the stability of myelin sheath, causing a series of neurological symptoms, mainly manifested as abnormal behavior, cognition, emotion, vision and hearing loss, etc.; in adrenal cortical cells Aggregation can cause the function of the adrenocorticotropic hormone (ACTH) receptor on the surfac...
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