The invention relates to a production method of strong-solvent-resistant thermosetting organic fluorescent pigment. The production method comprises the following steps of: primary feeding, mixing, high-speed dispersion, polymerization, constant-temperature baking, curing, coarse grinding, fine grinding, secondary feeding, mixing, color matching, detection and package, wherein the polymerization is steam low-temperature polymerization; after the step of fine grinding and before the step of secondary feeding, adding the steps of acidizing, dehydrating and drying. The production method has the advantages that due to adoption of low-temperature steam for thermal reaction, the reaction time is prolonged by 2.5 hours compared with that in the existing process, the intermolecular hydroxylation and etherification reaction are effectively enhanced; due to the acidizing process, the free formaldehyde in a product is effectively removed, unreacted small molecules at the condensation stage are promoted to react continuously, and further the molecular crosslinking degree is improved; and the decomposition points of the product are improved, the damage of strong solvents such as ketone and ester can be effectively resisted, the solvent resistance is greatly improved, and the application of the thermosetting organic fluorescent pigment in the aspects of paint and oil ink is expanded.