The invention discloses a high-strength low stress cast nodular cast iron with high elasticity modulus. The nodular cast iron comprises the following components by mass percent: 3.7-3.9% of C, 2.0-2.2% of Si, 4.50-4.65% of CE, 0.5-0.6% of Mn, less than or equal to 0.03% of P, less than or equal to 0.02% of S, 0.03-0.06% of Mg, 0.01-0.02% of RE, 0.5-0.7% of Cu, and 0.05-0.06% of Sn. A manufacture method of the nodular cast iron is characterized by high temperature pure iron liquid of base iron, compound alloying and accurate addition; according to the microscopic structure of the manufactured nodular cast iron, the content of pearlite is more than or equal to 95%, the nodularity is more than or equal to 90%, spherulitic graphite number in unit area is 200-380 / mm<2>, the yield strength is over 400MPa, the strength of extension is over 700MPa, the elastic modulus is more than 170GPa, the hardness HB is 190-250, the elongation is more than 3%, the casting inner stress is less than or equal to 50MPa, namely, with high carbon equivalent and high silicon-carbon ratio, the nodular cast iron has excellent performances such as high strength, high elasticity modulus and low stress, thus meeting the technical requirement of casting of machine tools.