161 results about "Borylation" patented technology

The invention relates to a directional power-assisted oil composition and its application and mainly solves the problems of poor compatibility between a directional power-assisted oil and a rubber sealing member and the fault of a power steering system due to deformation or failure of the rubber sealing member with the application of a power-assisted oil composition in the power-assisted steering system in the prior art. The directional power-assisted oil composition comprises the following components of: by weight, a) 0.1-5 parts of boron polyisobutylene succinimide; b) 95-99.9 parts of base oil. By the adoption of the technical scheme, the problems are greatly solved. In addition, the technical scheme can be used in the industrial production of the directional power-assisted oil composition provided by the invention.

The invention discloses a high selectivity method for synthesizing moxifloxacin. The method comprises the following steps of: reacting boric anhydride with trifluoro acetic anhydride to obtain a chelant; reacting 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester with the chelant, cooling to room temperature, adding ice water, performing suction filtration, and washing a filter cake with water until neutrality to obtain a 1-ethyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid methyl ester trifluoroacetic anhydride boronized chelate; and reacting the 1-ethyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid methyl ester trifluoroacetic anhydride boronized chelate with (S,S)-2,8-diazabicyclo[4,3,0]nonane to obtain a 1-cyclopropyl-6-fluoro-7-([S,S]-2,8-diazabicyclo[4,3,0]nonane-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid ethyl ester trifluoroacetic anhydride boronized chelate, recycling a solvent under reduced pressure, adding alkali, refluxing, discoloring, filtering, freezing, performing suction filtration, and drying a filter cake. The method is simple, mild in conditions, and high in selectivity, avoids difficultly separated impurities, is high in reaction yield and product purity, and is suitable for industrial production.

The invention relates to a new method for preparing crystalline transitional metal boride CoB (cobalt boride) with oxide or hydroxide of cobalt and borohydride of cobalt through solid phase reaction. The method provided by the invention comprises the steps as follows: uniformly mixing oxide or hydroxide of cobalt and borohydride of cobalt according to the molar ratio of 1:1 to 1:1.5, tabletting under the pressure of 15 to 20 MPa, keeping the temperature of 400 to 800 DEG C for 6 to 24 hours under the protection of argon gas, and cooling to the ambient temperature slowly; and the obtained product is washed fully with deionized water and alcohol and then vacuum dried, thus the product CoB can be obtained. The method has the characteristics that the synthetic method is novel, the adopted process is simple, and pure crystalline CoB can be obtained without high temperature, high pressure or other complicated procedures; and the used raw materials are simple and easy to obtain, and the cost is low, so that the method is applicable to mass production.

The present invention relates to a novel method for ruthenium-catalyzed selective boronation reaction of amides. According to the method, a hexacoordinated metal ruthenium complex containing a norbornadiene (NBD) ligand is taken as a catalyst, an N,N-disubstituted amide and bis(pinacolato)diboron are taken as reaction substrates, and in the absence of reaction solvents and under mild reaction conditions, a carbon-hydrogen bond of methylene at the ortho position of a nitrogen atom in the N,N-disubstituted amide is selectively subjected to a boronation reaction under efficient catalysis, so thata corresponding amide borate product is obtained. Compared with currently reported methods, the novel method generally has the advantages of wide substrate applicability, low catalyst usage amount, simple operation and the like. The method of the present invention realizes for the first time a selective C(sp3)-H boronation reaction of N,N-dimethyl substituted aromatic amide derivatives. In addition, the method realizes for the first time a metal-ruthenium-catalyzed selective dehydro-boronation reaction of N,N-disubstituted amides, and provides a completely new reaction strategy for organic synthetic intermediates of amide borates.

The invention provides a preparation method of a rutile type boron-doped titania (B-TiO2) microsphere with an exposed high energy crystal face {001} and belongs to the technical field of the preparation of inorganic material. The preparation method comprises the following specific steps: adding titanium boride (TiB) into a hydrochloric acid solution hydrazine containing natrium fluoride (NaF) to obtain a mixed solution, forcefully agitating, then transferring the mixed solution to a reactor with a polytetrafluoroethene lining, keeping the mixed solution at a constant temperature of 200 DEG C for 12-24 hours, naturally cooling the mixed solution to the room temperature so as to obtain a product, filtering the product, respectively washing and settling the product with distilled water and absolute ethyl alcohol for three times, drying the product at a temperature of 60-80 DEG C for 12-24 hours, and finally preparing the B-TiO2 microsphere with the exposed high energy crystal face {001}, of which exposing rate nearly reaches 100 percent. The preparation method is simple in preparation technology and good in repeatability; the prepared B-TiO2 microsphere is controllable and uniform in size and has a diameter of 3-5 micron; the element boron is doped, and is uniform in distribution and controllable in the amount of dopping; in addition, the prepared B-TiO2 microphere has excellent visible light catalytic activity, and is likely to be widely applied in the fields of photolytic water hydrogen preparation, organic contaminant degradation and the like.

The invention discloses a method for high-purity and high-yield preparation of p-chlorophenylboronic acid. The method comprises: (1) carrying out a Grignard reaction on magnesium chips and 1,4-dichlorobenzene under the action of an initiator to obtain a 4-chlorophenyl magnesium chloride Grignard reagent; and (2) carrying out a deep low temperature reaction on the 4-chlorophenyl magnesium chloride Grignard reagent obtained in the step (1) and trialkyl borate, carrying out acidolysis, and treating to obtain p-chlorophenylboronic acid. With the technical scheme of the present invention, the raw material cost and the production cost are substantially reduced, the reaction effect is good, the conversion rate during the boronization reaction is increased, the generation of the by-product impurities is reduced, the post-treatment is simple, the product purity is high, and the environmental pollution is reduced.

The invention discloses a synthesis method of cycloalkene-1-boronic acid pinacol ester. The synthesis method comprises three reaction steps of enabling cycloketone to react with phosphorus pentachloride to obtain 1-cycloolefin chloride, preparing cycloalkene-1-boronic acid through 1-cycloolefin chloride, lithium metal and a boronizing agent by the one-step method, and enabling cycloalkene-1-boronic acid to react with pinacol to obtain the final product. According to the method, the reaction is under mild conditions, 1-cycloolefin chloride can directly enter the next reaction without distilling and purifying, and intermediates and products obtained in each step do not need distilling, so that the operation is simple, and moreover, the raw materials are low in cost and easy to obtain, and as a result, mass production can be performed.

The invention relates to a boron-induced amorphous layered double hydroxide electrocatalyst as well as preparation and application thereof. The preparation method comprises the following steps: firstly, synthesizing a transition metal layered double hydroxide nanosheet crystal precursor on a foamed nickel substrate by utilizing an in-situ growth method; and amorphizing the crystal precursor through a room-temperature boronizing method to finally prepare the self-supporting hydrogen evolution catalyst of the amorphous layered double hydroxide nanosheet. Compared with the prior art, the method for inducing the amorphization of the layered double hydroxide crystals by doping boron atoms enables the electrocatalyst to have more active sites, lower electron transfer impedance and better corrosion resistance. When the electrocatalyst is used in a hydrogen evolution reaction, the electrocatalyst can show excellent electrocatalytic activity and stability under the condition of great current density.

The invention belongs to the technical field of functional materials and discloses a soluble graphene nanoribbon as well as a synthetic method and an application thereof. The synthetic method comprises the steps that 2,6-dibromo-4-nitroaniline and alkyl/alkoxy arylboronic acid have a Suzuki coupling reaction, 2,6-bis(4-alkyl/alkoxy benzene)-4-nitroaniline is obtained and reduced, 2,6-bis(4-alkyl/alkoxy benzene)-1,4-phenylenediamine is obtained and has halogenation, 2,6-bis(4-alkyl/alkoxy benzene)-1,4-dibromo/iodobenzene is obtained and has an Miyaura borylation reaction, and 2,6-bis(4-alkyl/alkoxy benzene)-4-boronic acid pinacol ester-1-bromo/iodobenzene is obtained; then a poly-para-phenylene derivative is generated through the Suzuki coupling reaction, and a product is obtained through oxidative dehydrogenation. The soluble graphene nanoribbon can be applied to the fields of field effect transistors, photovoltaic cells, non-linear optics and sensing.

The invention belongs to the technical field of medicine synthesis, and in particular relates to a method for synthesizing a Crizotinib intermediate. The method comprises steps of: a) reacting a raw material 4-mesylate piperidine-1-formic acid tert-butyl ester (2) with 4-nitro pyrazole to prepare a compound 3; b) reducing nitro by using hydrazine hydrate to obtain an amino compound 4; and c) diazotizing the compound 4 by using tert-butyl nitrite, and reacting the compound 4 with a boric acid ester compound 5 in the presence of a free radical initiator benzoyl peroxide, so as to prepare the Crizotinib intermediate (1). Compared with an existing synthesis method, the method provided by the invention has the following advantages: a diazotization method is used to synthesize the boric acid ester product; and compared with an existing Miyaura boronation method catalyzed by Pd, the method avoids the usage of expensive palladium catalyst and ligand, and has the merits of mild reaction condition, high yield, simple operation, cheap and easily available raw materials and short reaction period, and is quite easy for industrialized mass production.

Provided are: a carbon material which has boron atoms and/or phosphorus atoms with their characteristic structures and functions intact introduced into a carbon material such as carbon nanotubes; anda method for manufacturing the carbon material. This carbon material has boron atoms and/or phosphorus atoms introduced to a proportion of the carbon atoms that constitute the carbon material, and ismanufactured by the method for manufacturing the carbon material, the method including: a step of bringing into contact a fluorination processing gas that includes a fluorine-containing gas with the carbon material to perform fluorination processing on the surface of the carbon material; and a step of bringing into contact a boronizing gas that includes a boron-containing gas with the carbon material after the fluorination processing to boronize the carbon material and/or bringing into contact a phosphorizing gas that includes a phosphorus-containing gas with the carbon material after the fluorination processing to phosphorize the carbon material.