The invention discloses an industrial preparation method of 2,4,5-trifluoro-3-methoxybenzoyl chloride. The industrial preparation method comprises the following steps: 1) using methylamine to react with tetrachlorophthalic anhydride to get N-methyl tetrachlorophthalimide; 2) enabling the N-methyl tetrachlorophthalimide obtained in the step 1) to react with an alkali metal fluoride to get N-methyl tetrafluorophthalimide; 3) enabling the N-methyl tetrafluorophthalimide obtained in the step 2) to perform mixed reaction with sodium hydroxide to get 2,4,5-trifluoro-3-hydroxy sodium phthalate and then performing decarboxylation and acidification to get 2,4,5-trifluoro-3-hydroxybenzoic acid; 4) enabling the 2,4,5-trifluoro-3-hydroxybenzoic acid obtained in the step 3) to react with dimethyl sulfate to get 2,4,5-trifluoro-3-methoxybenzoic acid sodium and then acidifying to get 2,4,5-trifluoro-3-methoxybenzoic acid; 5) enabling the 2,4,5-trifluoro-3-methoxybenzoic acid obtained in the step 4) to react with thionyl chloride and N,N-dimethylformamide to get the 2,4,5-trifluoro-3-methoxybenzoyl chloride.