52results about How to "Reduced risk of degradation" patented technology

A method of using a dynamic plate surgical implant includes removing a patient's degenerated disc between upper vertebrae and lower vertebrae; inserting an artificial replacement disc between the upper vertebrae and lower vertebrae where the degenerated disc was removed; attaching a dynamic plate surgical implant to an anterior of the upper vertebrae and the lower vertebrae, the dynamic plate surgical implant including an upper plate member and a lower plate member dynamically connected through a dynamic movement mechanism that allows extension, flexion, lateral flexion right an left, and rotation of the upper plate member relative to the lower plate member; and using the dynamic plate surgical implant to prevent the artificial replacement disc from kicking out anterior to the vertebrae while allowing the patient's spine to maintain its normal range of motion, reducing the risk of degeneration in adjacent segment of the spine.

The invention discloses a portable fluorescence quantitative PCR detector, and belongs to the fields of biology and medical detection. The detector comprises an optical excitation unit, an optical detection unit, and a temperature control unit. The optical excitation unit comprises a plurality of light sources, an exciting light optical filter, and a holophote. The temperature control unit comprises a reaction tank, a heat cover, a heating / refrigerating sheet, a heat dissipating part, and a temperature control circuit. The optical detection unit comprises a plurality of light splitting sheets, an optical filter, an imaging sensor, and a detection circuit. The light given off by the light source goes through the exciting light optical filter and then is converted into exciting light with a specific wavelength; then the exciting light is reflected by the holophote and is projected into a PCR tube to excite the fluorescence substances in the reagent, thus the fluorescence substances will give off light, part of the light goes though the hole in the side surface of the reaction tank and enters the optical detection unit, the light is split and filtered in the optical detection unit, and finally the light form an image on the corresponding image sensor.

The invention discloses an optical excitation and detection system of a fluorescent quantitative PCR detector, and belongs to a field of biological and medical science detection. The system provided by the invention comprises an optical excitation unit and an optical detection unit, wherein the optical excitation unit comprises several light sources, an excitation light optical filter and a holophote; the optical detection unit comprises several light splitting pieces, optical filters, imaging sensors and detection circuits. Light emitted from the light sources is formed into excitation light of a specific wavelength by the excitation light optical filter, the excitation light is reflected by the holophote and enters into a PCR test tube, fluorescent substances in an excitation light irradiation agent emit light, a part of the light enters into the optical detection unit from a hole in the side surface of a reaction tank, and finally the light is split and filtered by the optical detection unit and is imaged on the imaging sensors.

The invention relates to an aerosol delivery system for delivering aerosolised medicament particles to a user comprising a cartridge and a device configured to receive the cartridge. The cartridge comprises: a first compartment comprising a delivery enhancing compound source; a second compartment comprising a medicament source; a vaporiser for heating the medicament; and a transfer element for conveying the medicament from the second compartment to the vaporiser. The cartridge may further comprise an aerosol forming chamber in fluid communication with the first compartment and the second compartment. The device comprises: an outer housing; a power source; temperature controlling means for controlling the temperature of the first compartment of the cartridge; and electronic circuitry configured to control power to the temperature controlling means from the power source. The electronic circuitry is configured to maintain the first compartment of the cartridge at a temperature of between about 30DEG C and about 50DEG C. In use, the medicament reacts with the delivery enhancing compound in the gas phase to form aerosolised medicament-containing particles.

The invention discloses a high throughput detection kit of SARS-CoV-2. The kit comprises 274 primers, wherein nucleotide sequences of the 274 primers are successively shown by SEQ ID NO: 1 to SEQ ID NO: 274. According to the invention, a multiple PCR technology and an NGS sequencing technology are used for million-multiple enrichment of SARS-CoV-2 analysis; through setting of external parameters and internal parameters of a known copy number, whether the SARS-CoV-2 exists or not can be detected sensitively, and a concentration of the SARS-CoV-2 can be judged; and total length data of the SARS-CoV-2 can be obtained, and research on evolution and variation of the SARS-CoV-2 is of high sensitivity, specificity and accuracy. Meanwhile, reverse transcription and the multiple PCR technology arecombined into one step, so that risks in SARS-CoV-2RNA degradation are reduced. The detection kit has important application values.

Water dispersible or water soluble porous bodies comprising a three dimensional open-cell lattice containing 10 to 95% by weight of a polymeric material which is soluble in water, and, less than 5% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry (as hereinafter described) of at least about 3 ml / g, and, with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm. And a method for making the same comprising the steps of: providing an intimate mixture of the polymeric material and any surfactant in a liquid medium: providing a fluid freezing medium at a temperature effective for rapidly freezing the liquid medium; cooling the liquid medium with the fluid freezing medium at a temperature below the freezing point of the liquid medium for a period effective to rapidly freeze the liquid medium; and freeze-drying the frozen liquid medium to form the porous bodies by removal of the liquid medium by sublimation.

The invention discloses a low-odor spray-coating-free PC / ABS (polycarbonate / acrylonitrile butadiene styrene) material and a preparation method thereof. The material is prepared from the following ingredients including 40 to 80phr of PC, 20 to 60phr of ABS, 5 to 10phr of AS, 0 to 1phr of lubricating agents, 1 to 1.5phr of deodorants, 0.5 to 1phr of heat stabilizers, 0.5 to 1phr of color masterbatch, 0 to 10phr of compatibilizers, 0 to 5phr of processing auxiliary agents, 0.1 to 0.5phr of antioxidants and 0 to 5phr of ultraviolet light absorbers. The material has the low odor and spray-coating-free appearance requirements; the odor grade is lower than or equal to 3.0; the appearance luster is good; the blackness is high; the thermal stability is high; the defects of flowing marks, melting and connecting wires, silver silks and the like cannot be easily generated; the spraying work procedure is omitted; the good spray-coating-free effect is achieved; through the creative selection on raw materials and auxiliary agents and the process innovation, a low-odor spray-coating-free PC / ABS material is produced, and is obviously superior to similar products in the market.

The invention relates to compound omeprazole dry suspension and a preparation method thereof. The dry suspension is particularly suitable for patients who have difficulty in taking common oral preparations such as tablets and capsules, old people and child patients. The dry suspension consists of omeprazole, sodium bicarbonate and pharmaceutically acceptable medicinal carrier. Sodium bicarbonate can improve the pH value of the gastric environment and maintain the pH value for certain time, so that the acid-labile omeprazole is quickly absorbed before being destroyed by gastric acid. The dry suspension is characterized in that the granularity of the omeprazole serving as one of main medicament components is controlled in a certain range, so that the prepared omeprazole preparation can be quickly dissolved and absorbed in the gastric environment and quickly and directly achieves an effect of inhibiting secretion of the gastric acid; and when the omeprazole is prepared into the dry suspension, the omeprazole can be uniformly dispersed in the stomach, so that the acting area in the stomach is enlarged, and an ideal curative effect is achieved.

An extra-discal device for intervertebral stabilization includes at least one rigid part connected to pedicle screws by an element. This rigid part comprises a cylindrical body, each end of which is firmly attached to the element which is flexible and deformable so as to be linked to a part of a corresponding pedicle screw with reduced play to obtain a limited range of multidirectional movement in the sagittal, horizontal and frontal planes, while limiting translational movement to the axis of the screw.

The present invention relates to an aerosol-generating system comprising a first container comprising at least one aerosol-generating substrate, the aerosol-generating system further comprising a rupturing system, wherein the rupturing system comprises: a first tube and a second tube, wherein the first tube and the second tube are arranged in operational engagement defining a volume, wherein the first tube and the second tube are movable relative to each other along a first motion path from a first position to a second position, such that the defined volume is larger in the first position than in the second position, wherein the first tube comprises a first rupturing member, arranged at least partially inside the first tube, such that in the first position, the first rupturing member is contained completely in the defined volume of the first tube and the second tube, and wherein in the second position, the first rupturing member at least partially protrudes from the defined volume to rupture the container comprising the at least one aerosol-generating substrate.

A compound dry suspension preparation containing omeprazole and sodium bicarbonate is characterized in that the sodium bicarbonate is adopted as buffer agent, and xanthan gum is adopted as suspending agent. The invention further relates to a preparation technique which relates to the particle size of xanthan gum.

The invention discloses a kit and an extraction method for rapidly extracting RNA of animal fecal microorganism. The kit mainly adopts a silicone mold adsorption column to absorb the RNA of the fecal microorganism, and then adopts a peculiar protein removing solution and a rinsing solution to wash away impurities such as proteins and the like. Compared with the conventional method for extracting the RNA of the animal fecal microorganism, the extracting method by using the kit saves plenty of time for extraction and meanwhile simplifies experimental procedure, and can extract the RNA of the animal fecal microorganism more effectively, rapidly and economically.

Water dispersible or water soluble porous bodies comprising a three dimensional open-cell lattice containing 10 to 95% by weight of a polymeric material which is soluble in water, and, less than 5% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry (as hereinafter described) of at least about 3 ml / g, and, with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm. And a method for making the same comprising the steps of: providing an intimate mixture of the polymeric material and any surfactant in a liquid medium: providing a fluid freezing medium at a temperature effective for rapidly freezing the liquid medium; cooling the liquid medium with the fluid freezing medium at a temperature below the freezing point of the liquid medium for a period effective to rapidly freeze the liquid medium; and freeze-drying the frozen liquid medium to form the porous bodies by removal of the liquid medium by sublimation.

The invention provides a continuous fiber 3D printing device and a continuous fiber 3D printing method. The continuous fiber 3D printing device comprises a fiber roller, a gumming part and a printingpart; the gumming part is provided with a housing injected with a resin solution; a tension roller, a gumming opposite-opening roller and a traction roller are sequentially arranged in the housing; the tension roller is arranged above a liquid level of the resin solution and is used to provide dry fiber with a part of pre-tightening force by the action of frictional force; the gumming opposite-opening roller is arranged below the liquid level of the resin solution; the gumming opposite-opening roller and the tension roller form an included angle; the traction roller is arranged above the liquid level of the resin solution and is used to provide traction force; and the dry fiber enters into the gumming part through the fiber roller, is gummed by the tension roller, the gumming opposite-opening roller and the traction roller sequentially, and then is printed by the printing part. The intensity of an obtained workpiece is improved by more than 4 times compared with that of a workpiece in3D printing of existing resin, so that a foundation is laid for high-performance printing components applied to the aerospace field.

The invention relates to a preparing method of a mother culture special for production of Cordyceps militaris. The preparing method includes: adding, according to a certain ratio, nutrient solution containing cane sugar, monopotassium phosphate and magnesium sulfate to wheat bran and millet, adjusting pH to obtain a medium, charging the medium in a flask, performing sterilizing at 121 DEG C for 30 min, in aseptic conditions, inoculating a spawn of Cordyceps militaris, performing culturing constantly at 18 DEG C to 25 DEG C for 7 to 14 days to obtain the mother culture. After the mother culture is added a certain amount of aseptic water, the mother culture is inoculated to a fermentation tank or solid medium, and the mycelia and fruiting bodies of Cordyceps militaris can be produced on a large scale. The preparing method has the advantages that the step amplified cultivation process is omitted, the production cycle is shortened by greater than one third, the cost of seed step amplification equipment is reduced, the production cost is decreased by greater than one third, inoculating is simple, less contamination occurs, the risk of strain degeneration is reduced, and the mycelia and fruiting bodies of Cordyceps militaris can be industrially produced.

The present invention relates to a lighting device (1, 1a) comprising an envelope (3), a carrier (4) arranged inside the envelope (3) and having solid state light sources (5) mounted on the carrier (4), driver circuitry (10) spaced apart from the carrier (4), at least one power line (9) connecting the solid state light sources (5) and the driver circuitry (10), and a wireless communication circuit (13) for receiving control signals, and for controlling the light output, during operation, from the solid state light sources (5). The wireless communication circuit (13) is connected to the at least one power line (9) for using the at least one power line (9) as a wireless communication antenna.

The present invention relates to a lighting device (1, 1a) comprising an envelope (3), a carrier (4) arranged inside the envelope (3) and having solid state light sources (5) mounted on the carrier (4), driver circuitry (10) spaced apart from the carrier (4), at least one power line (9) connecting the solid state light sources (5) and the driver circuitry (10), and a wireless communication circuit (13) for receiving control signals, and for controlling the light output, during operation, from the solid state light sources (5). The wireless communication circuit (13) is connected to the at least one power line (9) for using the at least one power line (9) as a wireless communication antenna.

The invention relates to a preparation method of a semisolid preparation for psoriasis treatment; the preparation method comprises the specific steps of 1) adding a mixture of tacalcitol 1-5 ppm of total weight of the semisolid preparation and a therapeutically effective amount of corticosteroids into a matrix accounting for 2-40% of the prescription amount, and stirring and mixing; 2) stirring the remaining prescription amount of the matrix and other medicinal excipients under the protection of gas at the temperature of 60-90 DEG C and in a nitrogen-oxide molar ratio of not less than 3.7; 3) combining the mixtures of steps 1) and 2), and stirring and mixing under the protection of gas at the temperature of 60-90 DEG C and in a nitrogen-oxygen molar ratio of not less than 3.7 to obtain the semisolid preparation mixed well. The preparation method of the semisolid preparation for psoriasis treatment has the advantages that equipment requirements in the preparation process can be lowered, the complex preparation process is simplified, and the preparation time of the semisolid preparation is shortened at the premise of ensuring the distribution uniformity of active matters in the semisolid preparation.

The invention relates to a refining process of grease rich in natural antioxidants, and belongs to the technical field of edible oil refining processing. The method comprises the following steps: (1)decoloring, (2) dewaxing, and (3) deodorizing. The method disclosed by the invention has the beneficial effects that by reducing the temperature in each process, especially the temperature during deodorization, the original nutritional ingredients in the grease are reserved to the greatest extent, and the loss of the nutritional ingredients in the refining process is avoided. The new process has lower energy consumption, and the competitiveness of the product is enhanced.

A method is provided for fabricating a crystalline semiconductor photovoltaic cell, wherein the method comprises depositing a dielectric layer at first predetermined locations on a surface of a semiconductor substrate and growing a doped epitaxial layer at second predetermined locations on a surface of the semiconductor substrate, the second predetermined locations being different from and non-overlapping with the first predetermined locations. The dielectric layer is maintained as a surface passivation layer in the photovoltaic cell. The doped epitaxial layer forms an emitter region, a back surface field region or a front surface field region of the photovoltaic cell.

The invention discloses a microfluidic immunization and nucleic acid detection chip which comprises an immunization array chip detection module, a nucleic acid lysis-isothermal amplification detection module and a waste liquid pool; the immunization array chip detection module comprises a to-be-detected sample solution inlet, an immunization cleaning solution inlet, a secondary antibody solution inlet, an immunization reaction and detection chamber and a bent fluid channel; the nucleic acid lysis-isothermal amplification detection module comprises a nucleic acid lysis solution inlet, a nucleic acid cleaning solution inlet, a nucleic acid eluent inlet, a nucleic acid lysis chamber, a nucleic acid amplification reaction and detection chamber and a first outlet; and a first micro-fluid valve is arranged on a first channel, and a second micro-fluid valve is arranged on a second channel. The invention provides a microfluidic immunization and nucleic acid detection chip, which integrates sample introduction, treatment and detection, integrates immunization detection and nucleic acid detection, achieves fast, small and accurate effects, and realizes real-time or batch detection in a molecular detection technology.

The invention discloses a low-temperature high-yield single subunit RNA (ribonucleic acid) polymerase, namely VSW3RNA polymerase, which is applied to efficient synthesizing of RNA at low temperature.The single subunit RNA polymerase is RNA polymerase expressed by a low-temperature phage VSW-3, and can be used for transcribing and synthesizing RNA by taking DNA (deoxyribonucleic acid) as a template within the temperature range of 4-30 DEG C; when the temperature is 25 DEG C, the efficiency of synthesizing RNA by the VSW3RNA polymerase is the highest, and the yield of the VSW3RNA polymerase even exceeds that of T7RP which is widely applied to RNA in-vitro transcription synthesis at present. A base sequence for coding the enzyme is shown in a sequence table SEQ ID NO. 1, an amino acid sequence of the enzyme is shown in a sequence table SEQ ID NO. 2, and a specific promoter sequence recognized by the enzyme is shown in a sequence table SEQ ID NO. 5. The VSW3RNA polymerase is found to be afirst single subunit RNA polymerase which has RNA synthesis capability comparable to or even superior to that of T7RP, and the most suitable temperature for transcribing and synthesizing RNA is 25 DEG C and is 12 DEG C lower than the transcription temperature of 37 DEG C of T7RP, thus an important enzyme tool is provided for efficiently synthesizing RNA at low temperature, and the increasing requirements of scientific research and medical markets on RNA products can be met.

The invention belongs to the technical field of high-throughput sequencing and microbiological detection, and particularly relates to a method for detecting target microbiological genome RNA based on a high-throughput sequencing technology. The method comprises the following steps: carrying out nucleic acid extraction, DNA digestion, RNA purification, RNA fragmentation, inverse transcription synthesis of cDNA molecules, cDNA library construction, high-throughput sequencing and sequencing data analysis on a to-be-detected sample containing a target microorganism, and detecting the condition of the genome RNA of the target microorganism in the sample. In the DNA digestion step, digestion is carried out under mild conditions of incubation at 37 DEG C to 42 DEG C for 10 to 30 minutes using a DNA enzyme, and further, in the RNA fragmentation step, a thermal disruption means is used. According to the method, due to the adoption of a mild digestion means and a thermal interruption means, the microbial genome RNA can be efficiently and quickly enriched at low cost, the content of the microbial genome RNA is increased, and the success rate of constructing an RNA high-throughput sequencing library is increased, so that the detection sensitivity of the microbial genome RNA is improved.

The invention belongs to the technical field of pharmaceutical preparation, and in particular relates to a long-acting pharmaceutical preparation combination of leuprolide acetate and a use method ofthe pharmaceutical preparation combination. The long-acting pharmaceutical preparation combination of leuprolide acetate of the invention comprises separately independently stored leuprolide acetate or analogues of leuprolide acetate, biodegradable polymer microspheres and solvents; and the biodegradable polymer microspheres are microspheres formed by a mixture of PLGA and PCL. According to the present invention, by adopting the pharmaceutical preparation combination, the glass transition temperature of the polymer is reduced, the burst release of the drug at the beginning of release is reduced, and the yield of the biodegradable polymer microspheres is improved; the risk of polymer degradation during storage is reduced, the temperature of storage and transportation is also reduced, and the cost of storage and transportation is saved; and the problems that the drug loading of leuprolide acetate microspheres can not be increased and the burst release of the prior leuprolide acetate gel(Eligard) is too large are solved.

The invention belongs to the technical field of medicines, and particularly relates to procaterol hydrochloride oral liquid and a preparation method thereof. The procaterol hydrochloride oral liquid is prepared from the following raw material components in percentage by mass: 0.0005 percent to 0.001 percent of procaterol hydrochloride, 0.0025 percent to 0.0075 percent of ethylparaben, 0.00125 percent to 0.00375 percent of butyl paraben, 0.01 percent to 1.0 percent of essence, 1.5 percent to 5.0 percent of a solvent, 0.05 percent to 0.4 percent of sodium benzoate, 0.1 percent to 2.0 percent of citric acid, 0.05 percent to 1.0 percent of citrate, 25 percent to 50 percent of a flavoring agent and the balance of water, wherein the total mass of the procaterol hydrochloride oral liquid is 100 percent. According to the procaterol hydrochloride oral liquid, the stability of the procaterol hydrochloride oral liquid is ensured through the synergistic effect of all the raw material components and the mass percentage content, the risk of degradation of active ingredients of procaterol hydrochloride is effectively reduced, and the stability and the curative effect of the oral liquid are improved.

The invention discloses a preparation method of a nucleic acid primer preserving fluid, which is characterized in that the preserving fluid is prepared from the following components in 1000 mL: 2 to 3 parts of thiomersalate and 0.2 to 0.4 part of 1MTris-HCL; 0.1 to 0.3 part of a 0.5 M metal chelating agent; an acidity regulator and a buffer solution; and the balance of pure water. The preparation method comprises the following steps: fully mixing tris (hydroxymethyl) aminomethane, disodium ethylene diamine tetraacetate and pure water until the mixture is completely dissolved to form a first mixture; adding an acid-base regulator into the first mixture obtained in the step 1, mixing, regulating the pH value to 8.0, then adding thiomersalate, and finally adding pure water to a constant volume of 100ml to obtain the nucleic acid preserving fluid. The nucleic acid preservation solution can improve the stability of nucleic acid in a solution and delay degradation of the nucleic acid, so that the preservation period of the nucleic acid in a liquid state can be prolonged. Meanwhile, repeated freeze-dissolution can be effectively avoided, the experiment operation steps are reduced, and the whole experiment process is shortened.

The invention provides a silicon carbide device, a preparation method thereof and a semiconductor device. The silicon carbide device comprises a substrate, a drift region which is arranged above the substrate, a well region which is arranged above the drift region, a contact region which is arranged above the well region, a source electrode which is arranged above the well region and is positioned on the inner side of the contact region, and a doped thin layer which is arranged above the well region and the drift region, is positioned on the inner side of the source electrode, and comprises at least one n-type doped region and at least one p-type doped region. The silicon carbide device has relatively small on resistance and leakage current, and meanwhile, the silicon carbide device has relatively high application reliability.

The present disclosure relates to the technical field of computer vision, in particular to an image processing method and a training method for an image processing network. A training method for an image processing network, comprising: obtaining a first sample set, the first sample set including a plurality of sample data; for each sample data in the first sample set, processing the sample data to obtain a global image information The first image of the first image and the first label corresponding to the first image, and at least one second image containing partial image information and the second label corresponding to the second image; the first sub-network to be trained based on the first image and the first label Training is performed, and the second sub-network to be trained is trained based on the second image, the output result output by the first sub-network and the second label. The implementation mode of the present disclosure improves the network joint training effect and reduces the risk of network effect degradation.

A simplified method for extracting RNA of polyphenol plants based on nano magnetic beads comprises the steps of (1), preparing samples; (2) allowing cell lysis; (3) washing, and repeating washing; (4) dissociating. Total RNA in polyphenol plants is extracted by the method of the invention under high rate, and the total RNA has high purity and complete fragments and is directly applicable to subsequent detection. Nucleic acid extraction time is shorter than that of the use of common nano magnetic beads, the efficiency is higher, the operation is simple, automation is easier to implement, the reagent environment is friendly, and the safety is better.