Preparation method of semisolid preparation for psoriasis treatment
A semi-solid and psoriasis technology, which is applied in the field of preparation of semi-solid preparations, can solve the problems of long production time, difficulty in large-scale production, and difficulty in mixing, so as to reduce equipment requirements, reduce the risk of degradation, and ensure mixing The effect of uniformity
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[0042] The invention provides a preparation method of a semi-solid preparation for the treatment of psoriasis. The preparation method comprises the following steps:
[0043] 1) Stir and mix the semi-solid preparation with a total weight of 0.0001~0.0005% of tacalciferol, a therapeutically effective amount of corticosteroids, and a matrix of 2~40% of the prescription amount. The mixing temperature is 60~90℃, and the stirring rate is 800~ 10000rpm, stirring time is not less than 0.5min;
[0044] 2) Weigh out the remaining amount of the matrix except the matrix used in step 1), and stir at 20-100rpm for at least 10min under the condition of 60~90℃;
[0045] 3) Under the condition of 60~90℃, add the mixture obtained in step 1) to the mixture obtained in step 2), and stir at 20-100 rpm for at least 10 minutes to obtain a semi-solid preparation containing tacalciferol.
[0046] In a preferred embodiment, the preparation method is carried out in an environment where the light intensity does ...
Embodiment 1
[0059] Example 1 The method of preparing an ointment containing 4 ppm of tacalciferol was carried out according to the following steps:
[0060] 1) Under the conditions of light intensity of 60 lux and gas protection with a nitrogen-oxygen molar ratio of 10, the total weight of the ointment (5kg, the same below) of 0.0004% of the total weight of tacalciferol, 0.0005% of the total weight of the ointment of beta Mix methasone, then add 5% of the prescription amount of petroleum jelly; mix and stir at 6000rpm for 3min at 60℃;
[0061] 2) Weigh 95% of the prescription amount of petroleum jelly, add 2% light liquid paraffin of the total weight of the ointment and 0.0005% of the total weight of the ointment vitamin E alcohol (CAS number: 10191-41-0); at 60°C , Under the condition of light intensity of 60 lux and gas protection with a nitrogen-oxygen molar ratio of 10, stirring and mixing for 10 minutes at 40 rpm;
[0062] 3) Add the mixture prepared in step 1) to the mixture prepared in s...
Embodiment 2
[0064] Example 2 The method of preparing 5 ppm tacalciferol ointment was carried out according to the following steps:
[0065] 1) Mix 0.0005% of the total weight of the ointment (4kg, the same below) with clobetasol of 1% of the total weight of the ointment, and then add 8% of the prescription amount of Vaseline; at 90℃, the light intensity is 50lux , Under the condition of gas protection with a nitrogen-oxygen molar ratio of 50, mix and stir for 15 minutes at 800 rpm, take a sample and check with an optical microscope under a 400-fold field of view, and stop stirring after checking that there is no crystallization; if there is crystals, continue to stir until there are no crystal particles , The total time does not exceed 30min;
[0066] 2) Weigh 92% of the prescription amount of petroleum jelly, add 8% light liquid paraffin of the total weight of the ointment and 0.002% vitamin E alcohol of the total weight of the ointment (CAS number: 10191-41-0); at 90℃, light Under the condi...
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