The invention discloses gulose tablet excipient, which consists of the following ingredients in percentage by weight: 88 percent to 96 percent of gulose, 1 percent to 5 percent of starch octenyl succinate anhydride, 1 percent to 5 percent of silicon dioxide and 1 percent to 5 percent of porcellanite, and has the advantages that the mobility is good, the forming degree is good, the demolding performance is good, and the gulose tablet excipient can be directly tableted with medicine and water for preparing medicine tablets. The invention also discloses a medicine tablet, which is prepared from the following ingredients in percentage by weight: 75 percent to 85 percent of medicine active ingredients, 5 percent to 15 percent of gulose tablet excipient and 5 percent to 15 percent of water raw materials, wherein the gulose tablet excipient and the medicine active ingredients do not have incompatibility and reaction, in addition, the solvability is good, the flowability is good, and the medicine tablet is suitable for the direct tableting of various kinds of medicine. The invention also discloses a preparation method of the medicine tablet, which has the advantages that the preparation is simple, the implementation is easy, and the operation and the control are easy.