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98results about How to "Reduce dissolution rate" patented technology

Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same

A matrix type sustained-release preparation and a manufacturing method therefor are provided wherein dissolution with low pH dependence of a basic drug or a salt thereof at the early stage of dissolution can be ensured in a dissolution test, and wherein as the dissolution test proceeds, a ratio of a dissolution rate of the basic drug or the salt thereof in an acidic test solution to a dissolution rate of the basic drug or the salt thereof in a neutral test solution (dissolution rate in the acidic test solution / dissolution rate in the neutral test solution) decreases with dissolution time at the late stage of dissolution, as compared to the early stage of dissolution. According to the present invention, the matrix type sustained-release preparation contains a basic drug or a salt thereof and at least one enteric polymer, in which solubility of the basic drug or the salt thereof in a 0.1 N hydrochloric acid solution and a neutral aqueous solution, pH 6.0 is higher than in a basic aqueous solution, pH 8.0.
Owner:EISIA R&D MANAGEMENT CO LTD

Phosphate cement based patching material and preparation method thereof

InactiveCN107056225ARaise the initial pHReduce dissolution rateFiberMagnesium phosphate
The invention relates to a phosphate cement based patching material and a preparation method thereof. The patching material is prepared from the following ingredients in parts by weight: 100 parts of magnesium phosphate cement, 20 to 40 parts of mineral admixtures, 120 to 140 parts of fine aggregates, 0.5 to 1 part of water glass, 0.5 to 1 part of fiber and 20 to 30 parts of water. The preparation method is characterized in that the raw materials are proportionally weighed; magnesium oxide, monopotassium phosphate and composite retarders are firstly stirred and mixed; then, the magnesium phosphate cement is obtained; then, the mineral admixtures and the fine aggregates are added; after uniform stirring, the water glass, the fiber and the water are added; stirring is performed for 3 to 4 minutes by a stirring machine; the phosphate cement based patching material is obtained. The prepared phosphate cement based patching material by the invention has the advantages that the coagulation time is about 30 minutes; the restoration time is short; the construction is not influenced; the restoration effect is obvious; the application requirement of fast patching the damaged road surface is met; the phosphate cement based patching material is applicable to fast restoration projects of cement concrete pavements.
Owner:WUHAN UNIV OF TECH

Combating sinus, throat, and blood infections with xylitol delivered in the mouth

A method of suppressing bacteria that cause infections of the throat, sinuses, heart and arteries, and joints (arthritis) by delivering xylitol in a human mouth. The method is effective with troches of pure xylitol or with xylitol chewing gum or liquid, provided sufficient quantities of xylitol are delivered. Streptococcus mutans and Staphylococcus aureus in the blood are important contributors to plaque in arteries and on heart valves and bacterial arthritis. For people whose blood is not already infected with significant levels of these bacteria, every day use of xylitol sufficient to suppress these bacteria in the oral cavity will reduce their risk of subsequent cardiovascular disease, arthritis, and sinus infections. Strep throat is a common throat infection caused by Streptococcus pyogenes. Frequent bathing with xylitol, such as from time release in the mouth, will speed recovery from strep throat.
Owner:HALEY JEFFREY T

Method for preparing magnesium alloy with micro-arc oxidation ceramic membrane

The invention discloses a method for preparing a magnesium alloy with a micro-arc oxidation ceramic membrane, mainly solving the problem that in the prior art, the membrane is single in variety, and the conventional membrane layers are generally red, black, green and the like in color. According to the method, an alkali electrolyte is prepared by taking sodium metaaluminate, sodium hydroxide, ethylenediamine tetraacetic acid, potassium permanganate and hydrogen peroxide as electrolyte solutes, and using diionized water as a solvent, and the alkali electrolyte is subjected to micro-arc oxidation treatment so as to obtain the magnesium alloy with a yellow micro-arc oxidation ceramic membrane. The method disclosed by the invention is simple in preparation, low in cost, wide in application range and applicable to light metal. The prepared yellow ceramic membrane has the advantages of uniform color, smooth surface, good compactness, high wearing resistance, good corrosion resistance, good stability and the like, and is particularly applicable to danger warning and reminding on yellow labels on traffic signs.
Owner:GUILIN UNIV OF ELECTRONIC TECH

Aluminum alloy electric heater anode oxide film and preparation method thereof

The invention discloses an aluminum alloy electric heater anode oxide film and a preparation method thereof and belongs to the technical field of preparation of film materials. The preparation methoddisclosed by the invention comprises the following steps: adding multiple acids such as sulfosalicylic acid, boric acid, oxalic acid, sulfuric acid, aluminum sulfate octadecahydrate and the like intoelectrolyte, performing mixed acid anodic oxidation treatment at the temperature of 3-10 DEG C for 40 minutes under the mechanical stirring condition, wherein the current density is 1.5-2.5A / dm<2>. The preparation method disclosed by the invention is simple and feasible in process, and the prepared anode oxide film has high corrosion resistance.
Owner:JIANGSU UNIV

Oviductus ranae microcapsules and preparation method thereof

InactiveCN105533750ARetain kidney and essenceIt has the function of nourishing kidney and benefiting essenceFood shapingAcetic acidChloride
The invention discloses oviductus ranae microcapsules and a preparation method thereof, and belongs to the technical field of processing of functional oil and fat products. The microcapsules are prepared with sodium alginate and chitosan serving as wall materials and oviductus ranae serving as a core material. The microcapsules are prepared from, by mass, 1-3% of sodium alginate, 1-3% of chitosan, 1.5-8% of oviductus ranae, 2-6% of anhydrous calcium chloride, 0.5-1% of tween-80, 1% of acetic acid and the balance water. The preparation method of the microcapsules includes the main steps that 1, a wall material solution and an immobilization solution are prepared; 2, oviductus ranae and a sodium alginate solution are mixed according a certain proportion; 3, emulsification homogenization treatment is carried out; 4, the microcapsules are prepared through a piercing-solidifying method. According to the microcapsules and the preparation method thereof, bioactive substances of oviductus ranae are maintained, and many defects of oviductus ranae are overcome. The microcapsules are convenient to preserve, and the fishy smell of oviductus ranae is removed. The preparation method is easy to implement and beneficial for industrial production and opens up a new field for deep processing of rana temporaria.
Owner:JILIN UNIV

Acid solution spray dry-process flue gas desulfurization and modulating intensification method

InactiveCN1593731AFull use of desulfurization potentialGive full play to the catalytic oxidation effectDispersed particle separationParticulatesCatalytic oxidation
The invention relates to a kind of acidic-solution spraying dry-way stack-gases desulfurization and tempering intensification method, which is applicable in the field of stack gases desulfurization or desamination and the field of stack gases tempering. Spraying the acidic solution whose PH<=5.5 in the form of vaporific into stack gases, which contains fly ash or granule of the desulfurization agent in the desulfurization reactor or the flue between the tail of coal burning boiler and dust remover. So it can make the fog drip catch fly ash or granule of the desulfurization agent in stack gases efficiently and then form the liquid film on it. With the moisture in fog drip evaporating rapidly, the PH of remaining liquid film tends to step down and the acidity tends to be higher so that it is favorable to digesting the alkaline metal ion and the transition state metal ion having catalysis and oxidization. Then the sweet effective constituent granule contained in granule can be activated and participate in desulfurization reaction. In the result of that described above, then invention can intensify to decline the stack gases tempering of dust to the resistance and the oxidative extent to the sweet by-product; it can decline the proportion of astable sulfite; it can reduce the consumption of Ca matrix desulfurization agent for carbon dioxide; and finally it can improve the use ratio and the sweet efficiency of the drying-way desulfurization agent.
Owner:陶国龙

Cleaning method of anode net of ionic membrane electrolysis bath

The invention discloses a cleaning method of an anode net of an ionic membrane electrolysis bath. Through the method, a compound scale layer on the surface of the anode net can be effectively removed, a surface coating of the anode net can be prevented from being damaged, and a voltage of the electrolysis bath can be lowered. The method includes the steps of carrying out pre-cleaning and leakage testing on a cleaning bath through pure water and placing the electrolysis bath into the cleaning bath after a cathode and an anode of the electrolysis bath are pressed by plastic membranes at an interval; preparing a primary cleaning agent through the pure water, heating the primary cleaning agent to 55-85 DEG C, then cleaning the anode net of the electrolysis bath for 1-4 hours, draining the primary cleaning agent and adding the pure water for flushing, wherein the primary cleaning agent is composed of 2-6% of hydrochloric acid and 0.2-0.3% of lan-826 corrosion inhibitors in concentration percentage; and preparing a secondary cleaning agent through the pure water, heating the secondary cleaning agent to 55-85 DEG C, then cleaning the anode net of the electrolysis bath for 4-6 hours, draining the secondary cleaning agent and adding the pure water for flushing, wherein the secondary cleaning agent is composed of 3-8% of citric acid, 0.2-0.35% of lan-826 corrosion inhibitors and 3-6% of sulfamic acid in concentration percentage.
Owner:PANZHIHUA STEEL ENTERPRISES XINYU CHEM

High-dispersity edible instant thickener and preparation method thereof

The invention discloses a high-dispersity edible instant thickener and a preparation method thereof. The thickener comprises the following raw materials in percentage by mass: 1-10% of a block formation inhibitor, 20-75% of xanthan gum and 20-75% of dextrin, wherein the block formation inhibitor comprises a composition containing one or more of glutamic acid, aspartic acid, glycine, erythritol andpotassium chloride. The composition is prepared from the following components in percentage by mass: 16 to 24% of glutamic acid, 16 to 24% of aspartic acid, 16 to 24% of glycine, 5 to 10% of erythritol and 25 to 40% of potassium chloride. The invention also provides a preparation method of the thickener. The prepared thickener can improve the dispersity of liquid in the thickener and inhibit theblock formation, so that xanthan gum can fully exert a thickening function, and the special taste generated by potassium chloride can also be improved.
Owner:周益俊

Method for preparing continuous gradient biological coating by utilizing suspension plasma spraying

The invention discloses a method for preparing a continuous gradient biological coating by utilizing suspension plasma spraying. A calcium silicate/fluorohydroxyapatite continuous gradient biologicalcoating is prepared on the surface of a titanium or titanium alloy matrix by utilizing a suspension plasma spraying method. The high bonding strength between a calcium silicate coating and the titanium matrix and the low solubility of fluorohydroxyapatite are utilized, solid phase components of a mixed solution are gradually changed by adjusting the liquid feeding rates of two suspensions, the continuous gradient coating is prepared on the surface of the titanium or titanium alloy matrix by adopting a suspension plasma spraying technology, namely, the calcium silicate is arranged at the bottomof the coating, the fluorohydroxyapatite is arranged at the top of the coating, gradient component transition is achieved between the top and the bottom, the internal stress of the coating can be greatly reduced through gradient design, and the sensitivity at an interface is reduced. The binding force between the calcium silicate/fluorohydroxyapatite gradient coating and the titanium matrix is obviously improved, the dissolution rate is obviously reduced, and the coating shows good biological activity and antibacterial activity.
Owner:INNER MONGOLIA UNIV OF TECH

Uncoupling agent and application thereof

ActiveCN103771579AGood sludge reduction performanceReduce total phosphorus concentrationSustainable biological treatmentBiological water/sewage treatmentReduction rateAluminium
The invention relates to an uncoupling agent containing 2,4,5-trichlorophenol, a soluble metal salt and an adsorbent, wherein the soluble metal salt is soluble ferric salt and / or soluble aluminum salt. The invention also relates to the application of the uncoupling agent to an activated sludge method for the treatment of wastewater. In the process of the activated sludge method for the treatment of wastewater, the uncoupling agent provided by the invention can realize high COD removal rate and sludge reduction rate, and the water outlet has small TP concentration.
Owner:CHINA PETROLEUM & CHEM CORP +1

Transparent anti-fouling membrane preparation method

The invention belongs to the technical field of ocean engineering antifouling paint preparation, and particularly relates to a transparent anti-fouling membrane preparation method. The technological process comprises the steps that hydrotalcite nanosheets are dispersed in distilled water to obtain a hydrotalcite aqueous solution through ultrasound, polyvinyl alcohol is added into the hydrotalcite aqueous solution to be heated till polyvinyl alcohol is dissolved to form a mixed solution, standing is conducted on the mixed solution, the mixed solution is naturally cooled and then dispersed through ultrasound, phenolic amide antifoulant is added into the mixed solution, and an anti-fouling mixed solution is obtained through ultrasonic dispersion; the quartz surface is coated with the anti-fouling mixed solution through a spin-coating method or a coating method, and a transparent anti-fouling membrane is obtained after drying; the transparent anti-fouling membrane protects fouling of the parts such as detection shots, light sources and submarine windows of marine optical instruments. The molecular structure and preparation method of the transparent anti-fouling membrane are simple, the technology is scientific and reliable, the raw materials are low in cost and easy to obtain, the light transmittance is high, the antifouling activity is good, the effect is obvious, the application environment is friendly, and an important application prospect in the marine antifouling field is achieved.
Owner:725TH RES INST OF CHINA SHIPBUILDING INDAL CORP

Piracetam eutectic and preparation method thereof

InactiveCN109796393AConducive to production quality controlDelayed dissolution rateCarboxylic compound separation/purificationDouble bondCarboxylic group
The invention relates to the field of pharmaceutical materials, and discloses a piracetam eutectic, which is synthesized by using piracetam and gentilic acid, wherein the molecular formula is C6H10N2O2 C7H6O4, and the molecular weight is 296; the eutectic structure is that O atoms of phenolic hydroxyl groups adjacent to gentilic acid and carboxyl are used as hydrogen bond acceptors, and N atoms onpiracetam amino groups are used as hydrogen bond donors to form intermolecular double bonds; double bond O atoms on the gentilic acid carboxyl are used as hydrogen bond acceptors, and the O atoms onthe adjacent phenolic hydroxyl groups are used as hydrogen bond donors to form an intramolecular hydrogen bond so as to jointly form a basic unit of the eutectic; the crystal is c2 / c and monoclinic, and the cell parameters are shown in the description, wherein alpha=gamma=90 degrees, beta=101.09 degrees, Z=8. Compared with the original piracetam, the dissolution rate and stability of the medicineeutectic are greatly improved.
Owner:YUNNAN OPEN UNIV
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