46results about How to "Reduce aggregation rate" patented technology

The present invention provides an aqueous solution comprising an antibody protein at a concentration of at least about 10 mg / m L and a stabilizing amount of polyethyleneimine.

The invention discloses a magnetic targeting carrier capable of carrying genes and drugs, a preparation method and an application thereof. The invention is a carrier which has stability, safety and targeting and has controlled release behavior for non-viral magnetic gene therapy and drug therapy. The carrier material of the invention is characterized in that the carrier material is a bunchy silica mesoporous material with magnetism; the length-diameter ratio is not less than 3; the loading capability is big; the material has a protective effect on loaded genes and carriers and superparamagnetism, is not easy to agglomerate, and can control release speed of genes and drugs in vitro; and the surface thereof is easy to modify various functional groups, thus having wide adaptability. The invention also provides a preparation method of the carrier. When in use, therapeutic short chain DNA, siRNA or drugs enter in holes or are combined with surface modified functional genes by a soaking mode, then reach a targeted tissue by guidance of an applied magnetic field, and release the short chain DNA, siRNA or drugs carried thereby under the action of an alternating magnetic field, thus achieving the purpose of magnetic targeting controlled therapy.

The invention discloses a sugar-free heart-supplementing dragonhead granule, which is produced by following raw material of weight proportion: dragonhead extraction 1 to 10, starch1 to 10, calcium carbonate 1 to 10, dextrine 1 to 10, xylo-oligosaccharide 0.5 to 3, xylose 1 to 10, polyvinyl pyrrolidone solution and fruit flavor; preparation technology is as below: dragonhead extraction, starch, calcium carbonate, dextrine, xylose and fruit flavor are measured according to proportion, mixed evenly and crushed and sifted out through 80 mesh sieve, moistened using 0.01% to 0.05% of PVP ethanol solution before non-slurry pelletized at granulation machine and then dried, thereby producing the granule in pharmacy. The sugar-free heart-supplementing dragonhead granule has the advantages of having good taste, improving increment environment of bifidobacteria for intestines and stomach, improving digestion and absorption function for intestines and stomach and being suitable for adjuvant therapy of diabetic patients with cardio-cerebrovascular disease caused by diabetes.

The invention relates the use of codonopsis pilosula and astragalus root composition in treating ischemic heart diseases, wherein the composition has functions for treating myocardial ischemia, myocardiac infarction, myocardiopathy, and for treating thrombogenesis, lowering blood viscosity, and reducing platelet aggregation.

The invention discloses a preparation method of pseudo-boehmite with high purity and high crystallization degree. The method comprises the following steps: (1) bottom water is added into a pressure zone and a reaction zone of a reactor, and a stabilizing agent is added into water in the reaction zone; (2) an aqueous solution of aluminium salts and an alkaline solution are respectively injected into a feed inlet I and a feed inlet II at the upper part of the reaction zone of the reactor, a sol forming reaction is carried out, during the sol forming reaction process, when aluminium hydroxide sol reaches a certain concentration, a pressure pump pumps water in the pressure zone into a reaction zone through a semi-permeable membrane, the sol is kept in a concentration range, and the reaction is continuously carried out for a period of time; (3) after the reaction ends, a stirring paddle at the bottom of the reactor is started, pH value of the reactor is adjusted, temperature is rapidly raised to an aging temperature, after aging, filtering, washing and drying are carried out, the pseudo-boehmite is obtained. The pseudo-boehmite is prepared by a semi-permeable membrane penetration mode, and the obtained pseudo-boehmite has the advantages of high purity, high crystallization degree, and uniform particle size distribution; and the pseudo-boehmite is suitable for preparing carriers and catalysts of hydrotreatment catalysts for wax oil, heavy oil and other inferior raw materials.

The invention provides a super-junction VDMOS device comprising a first conductive type heavily doped semiconductor substrate, a metallized drain electrode, a first conductive type semiconductor column region and a second conductive type semiconductor column region. The first conductive type semiconductor column region and the second conductive type semiconductor column region are provided with three regions in which the doping concentration increases in sequence from bottom to top. The doping concentration of the P / N column uses a variable doping distribution which increases from bottom to top and the carrier lifetime of the JFET region is shortened by carrier lifetime control so that the current intensity flowing through the base region of the super-junction VDMOS uisng the structure canbe reduced, the conduction of the parasitic triodes inside the super-junction VDMOS can be effectively suppressed and the possibility of SEB of the device can be reduced. Meanwhile, the high doping concentration in the upper part of the P / N column forms a high barrier under the JFET region and the upper part of the P / N column so that the charge accumulation rate under the gate can be slowed downand the occurrence of SEGR can also be effectively suppressed through the carrier lifetime control of the JFET region.

The invention relates to a rapid synthesis device and method for a hydrate, and belongs to the technical field of natural gas hydrate application. According to the rapid synthesis device and method for the hydrate, a hydration reaction stirring system is designed, stirring parts with different specifications are arranged at different positions, and irregular disturbance of a hydration reaction system is realized; a hydration reaction circumferential self-rotating system is designed, and by means of liquid kinetic energy, circumferential stirring of the hydration reaction stirring system is realized; a hydration reaction axial self-rotating system is designed, the structures of a liquid inlet nozzles are changed, and by means of high-pressure liquid potential energy, kinetic energy and spring elastic potential energy, axial stirring of the hydration reaction stirring system is realized; and a stirring umbrella is arranged, the size of bubbles in the hydration reaction system is changed,and the hydration reaction rate is increased. The rapid synthesis device and method for the hydrate mainly aim at solving the problems of high stirring energy consumption, low reaction rate, low gasstorage capacity and the like in a hydrate production technology and have the advantages that continuous, rapid and efficient preparation of the hydrate is realized, and a new way for a natural gas storage and transportation technology is provided.

The invention discloses a health medical wine with the function of reducing three highs and a preparation method thereof. The heath medical wine is prepared from the following raw materials in parts by weight: 20-30 parts of lumbrukinase, 25-30 parts of hirudin, 5-15 parts of cassia occidentalis, 10-15 parts of fructus crataegi, 5-8 parts of dried orange peel, 15-20 parts of folium ginkgo, 6-12 parts of fructus lycii, 101-15 parts of flos chrysanthemi, 5-8 parts of fourstamen stephania root, 20-25 parts of radix puerariae, 5-8 parts of radix aristolochiae, 6-8 parts of radix aucklandiae, 10-15parts of flos chrysanthemi indici, 9-18 parts of catharanthus roseus, 4-8 parts of fructus forsythiae, 9-15 parts of selfheal, 2-6 parts of radix astragali, 3-7 parts of poria cocos, 3-6 parts of rhizoma atractylodis, 3-6 parts of rhizoma atractylodis, 10-18 parts of Chinese yam, 5-10 parts of rhizoma polygonati, 5-10 parts of rhizoma rehmanniae, 5-15 parts of radix scrophulariae, 5-10 parts of radix ophiopogonis, 5-8 parts of blueberry, 5-8 parts of mulberry, 6-12 parts of fagopyrum esculentum, 8-15 parts of benincasa hispida and 3-7 parts of radix notoginseng. The health medical wine can effectively reduce blood sugar, lipid and blood pressure, softens blood vessels, ensures the safety of three-high crowds and the stable diseases, and is good in health-care effect.

The invention discloses a combination drug containing hirudin for treating cardiovascular and cerebrovascular diseases. The combinatorial drug comprises natural hirudin and lumbrokinase as main active components and one of extracts from red-rooted salvia root, pseudo-ginseng, snake gourd fruit, astragalus root and ginseng as auxiliary component and is added with dispersant and preservative. Hirudin is used for promoting blood flow, lumbrokinase is used for recovery and reducing viscosity, and matched with the other two qi tonifying methods of traditional Chinese medicine, the combination drug is used for tonifying qi to effect a permanent cure and removing extravasated blood to take temporary solution, so that the qi tonifying product can effect in removal of extravasated blood without stagnation, the extravasated blood removal product can tonify qi without damage to vitality, qi is tonified while blood is promoted, vitality can be recovered, extravasated blood can be removed, and curative effect is guaranteed.

A semiconductor laser instrument for treating nasal disease by radiating nasal cavity is composed of a pair of semiconductor laser probes fixed on base and a controller. Said laser probes can be simultaneously inserted in nasal cavities for radiation. Its advantages are convenient therapy, high safety and reliability, and low cost.

A Chinese medicine for treating the cardiovascular and cerebrovascular diseases is prepared from astragalus root and safflower in weight ratio of 1:1.

The invention discloses a traditional Chinese medicine composition for treating chronic cardiac insufficiency, which is prepared by matching of the traditional Chinese medicines as follows: radix pseudostellariae, radix ophiopogonis, schisandra chinensis, astragalus membranaceus, the root of fangji, pepperweed seed, fructus trichosanthis, monkshood, poria cocos, pseudo-ginseng, bighead atractylodes rhizome, root of common peony, the root of red-rooted salvia, cortex acanthopanacis, Chinese-date, borneol, perillaseed, almond, pinellia ternate, caulis bambusae in taeniam and honey-fried licorice root. Aiming to the pathogenesis of heart failure: depletion of spleen and kidney, insufficient heart yang, blocking of blood vessel, damage of vital energy and blood, evil hydrops and pneuma rushing upwards to the chest, water and pneuma reversing upward and blocking of lung, the traditional Chinese medicine composition, disclosed by the invention, has the treatment rules of benefiting vitality and warming yang, purging the lung of pathogenic fire and promoting diuresis, promoting coronary circulation, improving blood supply of coronary artery, reducing blood pressure, purging the lung of pathogenic fire and regulating qi by alleviation of mental depression, clearing heat and eliminating phlegm, promoting diuresis and alleviating edema, enhancing systole, decreasing heart rate, reducing peripheral resistance, increasing cardiac output, improving microcirculation, relieving smooth muscle spasm and reducing blood platelet gathering rate.

The invention discloses a magnetic targeting carrier capable of carrying genes and drugs, a preparation method and an application thereof. The invention is a carrier which has stability, safety and targeting and has controlled release behavior for non-viral magnetic gene therapy and drug therapy. The carrier material of the invention is characterized in that the carrier material is a bunchy silica mesoporous material with magnetism; the length-diameter ratio is not less than 3; the loading capability is big; the material has a protective effect on loaded genes and carriers and superparamagnetism, is not easy to agglomerate, and can control release speed of genes and drugs in vitro; and the surface thereof is easy to modify various functional groups, thus having wide adaptability. The invention also provides a preparation method of the carrier. When in use, therapeutic short chain DNA, siRNA or drugs enter in holes or are combined with surface modified functional genes by a soaking mode, then reach a targeted tissue by guidance of an applied magnetic field, and release the short chain DNA, siRNA or drugs carried thereby under the action of an alternating magnetic field, thus achieving the purpose of magnetic targeting controlled therapy.

The invention discloses a preparation method of an aluminum oxide carrier. The method comprises the following steps: (1) bottom water is added into a pressure zone and a reaction zone of a reactor, ionic liquid I is added, and gelling temperature is adjusted; (2) an aqueous solution of alkaline aluminate is added into the reactor, at the same time CO2 enters the reaction zone from the lower part of the reaction zone, CO2 and the aqueous solution of alkaline aluminate are neutralized for carrying out a sol forming reaction, when water in the pressure zone enters the reaction zone through a semi-permeable membrane, the sol concentration is kept in a concentration range, and the reaction is continuously carried out; (3) after the reaction ends, ultrasonic vibration at the bottom is started, and after aging, washing and drying are carried out, pseudo-boehmite is obtained. (4) mixing and kneading, moulding, drying and calcination of the pseudo-boehmite prepared in the step (3), an adhesive and ionic liquid II are carried out, and the aluminum oxide carrier is obtained. The aluminum oxide carrier has the advantages of high specific surface area, large aperture and pore volume, high lateral compressive strength, and low abrasion; and the product is adapted to be the carrier of boiling bed wax oil, residual oil hydrogenation catalysts.

The invention discloses an application of isolated compounds from Salvia deserta Schang in the preparation of a drug with the anti-platelet aggregation effect. The application of the isolated compounds from Salvia deserta Schang in the preparation of the drug with the anti-platelet aggregation effect provided by the invention has the following benefits: according to in-vitro anti-platelet aggregation experiments on 7-O-acetylhorminone and horminone, the two componential monomers achieve better anti-platelet aggregation effect, certain quality dependency is shown among various concentration groups, and certain time dependency is shown among high concentration groups of the two components based on the fact that as time passes by, the platelet aggregation rate decreases and the inhibition rate increases; anti-platelet aggregation activity results indicate better activity of the two components, so that certain development and utilization value are achieved. The application can make up for the regional defect that Salvia miltiorrhiza drugs are absent in Xinjiang, thereby having remarkable market prospects.

The invention discloses a CRP latex enhanced kit and a preparation method and application thereof, which belong to the technical field of medical products. The CRP latex enhanced kit comprises a reagent R1 and a reagent R2, and the reagent R2 comprises the following components: a buffer solution 1, a buffer solution 2, latex microspheres 1, latex microspheres 2, EDC, a C-reactive protein antibody 1, a C-reactive protein antibody 2, a stabilizer and a sealing agent. The uniformly dispersed reagent R2 is obtained by controlling the feeding amount and simplifying the preparation process, the sensitivity of the obtained kit can achieve 0.15 mg / L, the CRP content at the high concentration level can be accurately determined, and the kit can be used for diagnosing various infectious diseases, inflammation diseases and other diseases.

The invention relates to an oral medicament for treating cerebral infarction and relieving limb spasm, and the oral medicament is prepared from the following traditional Chinese medicine active ingredients in parts by weight: 12-40 parts of membranous milkvetch root, 12-40 parts of pachyrhizua angulatus, 10-25 parts of red paeony root, 10-25 parts of szechuan lovage rhizome, 10-20 parts of peach seed, 10-25 parts of suberect spatholobus stem, 10-25 parts of common clubmoss herb, 10-25 parts of glandularstalk st.paulswort herb, 6-20 parts of twotooth achyranthes root and 3-10 parts of earthworm. Efficacy tests prove that the medicament can obviously inhibit the in-vivo blood vessel thrombosis of an animal, reduce the weight of in-vivo arterial and venous thrombus, inhibit the thrombosis and alleviate the clinical symptoms caused by the thrombus; and the medicament further has certain effect of improving coagulation function of rats, and can reduce the platelet aggregation rate, prolong the coagulation time, the PT (prothrombin time) and the APTT (activated partial thromboplastin time), have an obvious effect of improving blood rheology indicators, and can be used for significantly reducing blood viscosity of a rat blood stasis model caused by polymer dextran, improving the blood circulation, and avoiding the potential risk of the thrombosis.

An application of the medicine in the form of injection containing safflower in treating the aspirin-resistant cardiovascular disease is disclosed.

The invention relates to the technical field of floor heating pipes, and discloses a self-made banana peel graphene PE-RT super-thermal-conductive anti-scaling floor heating pipe, which comprises an outer heat conduction layer and an inner anti-scaling layer, the outer heat conduction layer is prepared from the following raw materials in parts by mass: 100 parts of PE-RT resin, and 10-25 parts of self-made banana peel graphene, and the inner anti-scaling layer is prepared from the following raw materials in parts by mass: 100 parts of PE-RT resin, 1-2 parts of surface modified nano TiO2, 0.3-0.5 part of an antibacterial agent and 1 part of color masterbatch. According to the invention, banana peel is activated in an inert atmosphere, and then a microwave oxidation-reduction technology is adopted to prepare biomass graphene with stable performance, namely banana peel graphene; and then the PE-RT resin is blended with a common PE-RT resin raw material to serve as an outer heat conduction layer of the super-thermal-conductive anti-scaling floor heating pipe, and the heat conduction effect of the prepared super-thermal-conductive anti-scaling floor heating pipe is greatly improved compared with that of a common PE-RT heat conduction floor heating pipe.

The invention relates to a drug composition for treating migraine and a preparation method thereof. The drug composition is prepared from, by weight, cynomorium songaricum, semen euryales, Japanese beauty-berry leaf, fructus galangae, folium sennae, cortex ailanthic, dianthus superbus, pyrrosia lingua, anisetree bark, swertia pseudochinensis, red halloysite; the medicine composition is formed by alcohol extraction aqueous extraction and others; 100 cases of migraine patients are treated, and the total effective rate is 98%; the effect is obvious, and no one has untoward effect and toxic side effect; thus the drug composition has significant treatment effect to treat migraine patient; the drug composition has good popularization value.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and carvedilol or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Carvedilol or the pharmaceutically acceptable salt thereof is calculated according to carvedilol, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of carvedilol to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

The invention discloses a preparation method of pleural lavage fluid. By adopting the preparation method, realizing the treatment of post-traumatic acute empyema. The preparation method comprises the following steps: (1) adding root and rhizome of Japanese false solomonseal, root or leaf of redback christmashush, hirsute shiny bugleweed herb, long pepper, red halloysite, cicada slough, fruit of bitter bottle gourd, asiatic pennywort herb, cornus wilsoniana, needle powder, mussel and ulva into ethyl alcohol to perform percolation; (2) concentrating a percolate by using a distillation kettle, continuously percolating a distillate, performing circulatory percolation and extraction, discharging and storing a filtrate, and storing filter residues for later use; (3) performing dealcoholization on the filter residues, then performing circulatory percolation, discharging a filtrate, and storing; (4) mixing the filtrates, heating, performing heat preservation, then refrigerating, and filtering; and (5) filtering by using a micro-porous filter membrane. Proven by clinical experiments, the pleural lavage fluid disclosed by the invention has the characteristics of relatively good curative effect and relatively high safety in treatment of post-traumatic acute empyema, and is worthy of being clinically applied and popularized.

The invention belongs to the field of medicines, and discloses a pharmaceutical composition used for treating cardiovascular and cerebrovascular diseases. According to the pharmaceutical composition provided by the invention, prasugrel or a pharmaceutically acceptable salt thereof, and rosuvastatin or a pharmaceutically acceptable salt thereof are adopted as pharmaceutically active ingredients. Rosuvastatin or the pharmaceutically acceptable salt thereof is calculated according to rosuvastatin, and prasugrel or the pharmaceutically acceptable salt thereof is calculated according to prasugrel. In the pharmaceutical composition, the weight ratio of rosuvastatin to prasugrel is 1:0.01-100, and preferably 1:0.2-20. When the pharmaceutical composition is applied in treating cardiovascular and cerebrovascular diseases, the effect is comprehensive, the toxic and side effects are low, and patient compliance can be improved. Therefore, the pharmaceutical composition has good medical application prospect.

The invention relates to a traditional Chinese medicine fragrance for relieving chronic heart failure. The traditional Chinese medicine fragrance is made from the following medicine materials: 15-30%of cypress powder, 1-3% of additional materials, and the balance fragrant medicine; and the fragrant medicine is made from the following medicine materials: astragalus membranaceus, salvia miltiorhiza, alisma orientalis, cinnamon twig, allium macrostemon, piper longum, albizia julibrissin, dragon teeth, Mother-of-Pearl, ginseng, radix pseudostellariae, white prepared lateral root of aconite, and lepidium seeds. The additional materials comprises rhizoma nardostachyos, honey and mother fungus package. The invention also relates to a preparation method of the traditional Chinese medicine fragrance. In the preparation method, superfine powder, volatile oil, and water extraction and alcohol extraction extract powder are prepared, a additional material liquid is prepared by mixing the volatileoil and the additional materials, the fragrant medicine powder mass is placed in a sealed tank for sealed fermentation, through spraying the additional material liquid multiple times, the permeabilityof the additional material liquid in the fermented fragrant powder mass is increased, and finally the traditional Chinese medicine fragrance that is capable of promoting pneumothorax, improving the microcirculation of patients with heart failure, relieving chronic heart failure, etc., is prepared.

The invention relates to the technical field of sewage purification, in particular to an urban sewage purifying and recycling device and a using method thereof. The urban sewage purifying and recycling device comprises a water passing tank, an extension pipe, an adapter plate, a supporting pipe, connecting plates, a filament, an upper plate and a vibration motor; a plurality of through holes are formed in the right end of the water passing tank, and springs are fixedly connected to the left portion and the right portion of the bottom end of the upper plate correspondingly; the bottom ends of the springs are fixedly connected with the top end of the adapter plate, the top ends of the two connecting plates are fixedly connected with a first wire and a second wire respectively, the right portion of the top end of the adapter plate is fixedly connected with a heating control device, the right portion of the bottom end of the water passing box communicates with a water outlet pipe, a valve is arranged at the bottom of the water outlet pipe, and the bottom end of the water outlet pipe communicates with a storage box; and a water guide pipe communicates with the right end of the extension pipe, and a heating plate is arranged in the middle of the water guide pipe; Impurities in a connecting pipeline can be cleaned conveniently, the blocking condition is reduced, the water freezing phenomenon is reduced, water circulation is facilitated, the impurity gathering probability is reduced, and practicability is high.

A Chinese medicine in the form of liquid injection for treating the aspirin-resistant cardiovascular disease is prepared from red sage root and dalbergia wood.

The invention belongs to the field of bioengineering, and particularly relates to a polypeptide nano-composite and a preparation method thereof.The polypeptide nano-composite comprises a tank body, a feeding pipe, a discharging pipe, a wastewater pipe and a filter screen cylinder; the top face of the tank body is communicated with a feeding pipe, the side face of the bottom of the tank body is communicated with a discharging pipe, the middle of the bottom face of the tank body is communicated with a waste water pipe, the middle of the inner bottom face of the tank body is fixedly connected with a filter screen cylinder, the inner ring of the filter screen cylinder is communicated with the waste water pipe, and the bottom end of the feeding pipe is located on the outer ring of the filter screen cylinder. During working, a soybean powder solution is added into the tank body through the feeding pipe, the solution is filtered through the filter screen cylinder, the filtered solution is discharged out of the tank body through the waste water pipe in the filter screen cylinder, soybean fibers are guided out of the tank body from the discharging pipe, and due to the fact that the filter screen cylinder is vertically arranged, the probability that the soybean fibers are gathered on the filter screen cylinder is reduced; the probability of blocking filter holes of the filter screen cylinder is reduced, and then the preparation efficiency of the polypeptide nano-composite is improved.

The invention relates to medicinal use of nalmefene hydrochloride. The nalmefene hydrochloride can improve lipid metabolism and improve prognosis of a fatty liver patient by reducing the platelet aggregation rate, improving the liver function state and resisting oxidation. The nalmefene hydrochloride can serve as a medicine for resisting human / animal fatty liver.

The present invention discloses a medicine composition for effectively curing coronary heart disease and angina pectoris. Said medicine composition is formed from 6 Chinese medicinal materials of salvia root, corydalis tuber, pueraria root, notoginseng, dalbergia wood and sappan wood. It can be made into various oral dosage forms. Besides, said invention also provides its preparation method and concrete steps.

An embodiment of the invention discloses a traditional Chinese medicine compound preparation for Chinese and western medicine combined treatment of coronary heart disease and angina pectoris, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine compound preparation is prepared from the following raw materials in percentage by weight: 11.1% of radixastragali, 5.5% of flos carthami, 5.5% of semen persicae, 8.3% of radix salviae miltiorrhizae, 5.5% of lignum santali albi, 2.8% of rhizoma ligustici, 8.3% of radix paeoniae rubra, 5.5% of radix angelicae sinensis, 11.1% of radix puerariae, 5.5% of lumbricus, 5.5% of rhizoma cyperi, 5.5% of pericarpium trichosanthis, 5.5% of rhizoma corydalis, 8.3% of roasted rhizoma atractylodis macrocephalae and6.1% of rhizoma dioscoreae. All the medicines are matched to remove blood stasis, relieve pain, tonify deficiency and eliminate phlegm, and the effects of promoting blood circulation to remove bloodstasis, removing stasis and eliminating stagnation are achieved. The traditional Chinese medicine compound preparation is combined with western medicines to treat the coronary heart disease, dredges coronary artery blood vessels to the maximum extent, is remarkable in curative effect, can reduce the seizure frequency of the angina pectoris, shorten the seizure time and relieve the angina pectoris,and has clinical popularization value.