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Combination drug containing hirudin for treating cardiovascular and cerebrovascular diseases

A hirudin-containing cardiovascular technology, applied in the field of drugs for the treatment of cardiovascular diseases, can solve the problems of inactivation of heparin, achieve the effect of improving cerebral ischemia and cerebral blood circulation, and reducing vertebral artery resistance

Inactive Publication Date: 2015-09-09
广西复鑫益生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Heparin cannot inactivate thrombin bound to thrombus, while hirudin and hirudin can inhibit thrombin both in circulation and bound to thrombus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 capsule prescription

[0034] Hirudin 1g

[0035] Lumbrokinase 2g

[0036] Danshen Extract 3000g

[0037] Dextran 10g

[0038] Ethyl p-hydroxybenzoate 0.5g

[0039] Excipients Appropriate amount

[0040] Preparation method: After the above two active ingredients are crushed and mixed evenly, a certain amount of auxiliary materials are added, mixed evenly, and packed into capsules to obtain 1000 capsules, which are packed in aluminum and plastic and then sealed in bottles.

Embodiment 2

[0041] Example 2 tablet prescription

[0042] Hirudin 2g

[0043] Lumbrokinase 10g

[0044] Panax notoginseng extract 2000g

[0045] Galactose 300g

[0046] Benzoic acid 1.5g

[0047] Preparation method: take the active extract, mix it with auxiliary materials evenly, use 5% starch slurry to make soft material, granulate with 18 mesh sieve, dry at 40°C, granulate with 16 mesh sieve, add sodium carboxymethyl starch, mix evenly, and press Into pieces.

Embodiment 3

[0048] Example 3 Enteric-coated tablet prescription

[0049] Tablet prescription:

[0050] Hirudin 2g

[0051] Lumbrokinase 20g

[0052] Astragalus Extract 2000g

[0053] Sucrose 100g

[0054] Benzoic acid 1.5g

[0055] 5% starch slurry appropriate amount

[0056] Starch 120g

[0057] Coating Solution Prescription:

[0058] PVAP 15%

[0059] Diethyl phthalate 5%

[0060] Talc 3%

[0061] Acetone / ethanol (1:1) to 100%

[0062] Preparation method: take the active extract, mix it with starch evenly, use 5% starch slurry to make soft material, granulate with a 30-mesh sieve, dry at 50°C, granulate with a 20-mesh sieve, add sodium carboxymethyl starch, mix evenly, and press of the core. Add PVAP, diethyl phthalate, and talcum powder to an appropriate amount of acetone / ethanol mixture, seal it, and stir it by magnetic force for about 2 hours, then add acetone / ethanol mixture to the full amount, and continue stirring for about 1 hour. The above tablet cores are coated. D...

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PUM

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Abstract

The invention discloses a combination drug containing hirudin for treating cardiovascular and cerebrovascular diseases. The combinatorial drug comprises natural hirudin and lumbrokinase as main active components and one of extracts from red-rooted salvia root, pseudo-ginseng, snake gourd fruit, astragalus root and ginseng as auxiliary component and is added with dispersant and preservative. Hirudin is used for promoting blood flow, lumbrokinase is used for recovery and reducing viscosity, and matched with the other two qi tonifying methods of traditional Chinese medicine, the combination drug is used for tonifying qi to effect a permanent cure and removing extravasated blood to take temporary solution, so that the qi tonifying product can effect in removal of extravasated blood without stagnation, the extravasated blood removal product can tonify qi without damage to vitality, qi is tonified while blood is promoted, vitality can be recovered, extravasated blood can be removed, and curative effect is guaranteed.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular diseases, in particular to a medicine for treating cardiovascular diseases containing hirudin. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases that threaten human health, such as coronary heart disease, angina pectoris, and myocardial infarction, whose mortality rates are increasing year by year. With the aging of my country's population structure, the number of patients with cardiovascular and cerebrovascular diseases is increasing. There are many methods and medicines for the treatment of cardiovascular and cerebrovascular diseases in traditional Chinese and Western medicine. Traditional Chinese medicine has unique advantages because of its high curative effect and low side effects. [0003] The etiology and mechanism of cardiovascular and cerebrovascular diseases are complex, and the root of the disease lies in defi...

Claims

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Application Information

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IPC IPC(8): A61K38/58A61P9/00A61P9/10A61K38/48
Inventor 谢海林
Owner 广西复鑫益生物科技有限公司
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