49results about How to "React clean" patented technology

The invention relates to a method for synthesizing sorafenib by solid state ball milling. This method takes compound 4-(4-aminophenoxy)-N-picoline-2-carboxamide and compound 4-chloro-3-trifluoromethyl isocyanate as raw materials, or compound 4-chloro-3- Trifluoromethylaniline, compound N, N'-carbonyldiimidazole and compound 4-(4-aminophenoxy)-N-picoline-2-carboxamide are raw materials, under the catalysis of a small amount of liquid (and base) , Sorafenib was synthesized by solid state ball milling in a ball mill. The main innovation of the present invention is that Sorafenib is synthesized by solid ball milling in a ball mill for the first time. Compared with the method of synthesizing Sorafenib in the original liquid solvent, the method of the present invention has fast reaction speed, no dust spillage, and controllable reaction Good performance, simple operation, high reaction yield, less pollution, strong feasibility and so on.

The present invention is preparation process of 1-chloro-3-(N-substituent)-tert-butyloxy formylamido-3-substituent-2-acetone. The preparation process has 1-diazo-3-(N-substituent)-tert-butyloxy formylamido-3-substituent-2-acetone as main material and HCl gas as chlorinating reagent, and includes dissolving the main material in dry solvent, introducing dry HCl gas into the solution under the protection of inert gas to react at the temperature from -40 deg.c to +40 deg.c and final decompression drying to eliminate solvent, with the molar ratio between the main material and HCl gas being 1 to 1-10. The preparation process realizes the reaction through controlling the amount of added HCl gas and the reaction temperature, and has low production cost and no industrial pollution caused by metal cation.

The invention discloses a synthesizing method for 1,2-dimethoxy benzene, which utilizes pyrocatechol, strong base and chloromethane as raw materials and water as solvent to react in a high pressure autoclave; wherein the mol ratio of strong base to pyrocatechol is 2-3:1, the mole ratio of chloromethane to pyrocatechol is 2-3:1, the reaction temperature is 50-100 DEG C, the reaction pressure is 0.3-0.5 MPa, the reaction time is 4-10h, and the 1,2-dimethoxy benzene is obtained through carrying out liquid separating and rectification on reaction liquid. The method of the invention is adopted to synthesize 1,2-dimethoxy benzene, thus having the characteristics of environment friendless, simple process and high yield.

The invention relates to synthesis of alpha-oxyamide through reaction of 2-hydroxy propylene cyanide as well as corresponding aldehyde or ketone and amine, which mainly solves the problems that the preparation of common alpha-oxyamide has a plurality of reaction steps, the reaction operation is complicated, the reaction cost is high, the post treatment is a trouble, and the like. According to the method, 2-hydroxy propylene cyanide as well as corresponding aldehyde or ketone and amine are directly mixed, methanol or acetonitrile is taken as the solvent, and the product can be obtained by stirring for 10-120 minutes. The method for synthesizing alpha-oxyamide is safe and efficient.

The invention belongs to the technical field of solar battery packaging assemblies and particularly relates to a solar battery back film subject to low-temperature plasma treatment. The solar battery back film is mainly formed by adhering a base layer and a fluorine-based film layer, wherein the surface of the base layer is provided with a plasma-treated film layer II or a plasma treatment surface grafting copolymer layer II, the surface of the fluorine-based film layer is provided with a plasma-treated film layer I, and the surface of the plasma-treated film layer I is provided with a plasma treatment surface grafting copolymer layer I. The invention further provides a preparation method of the solar battery back film. As the plasma-treated film layers and the plasma treatment surface grafting copolymer layers assist in blocking water vapor, the solar battery back film has the characteristics of better weather resistance, good chemical resistance and excellent electrical insulation. The preparation method is very quick in response, can achieve an expected purpose in a few seconds, is very suitable for a circulation system and facilitates continuous production of the solar battery back film.

The invention provides a method for preparing N-methylpiperazine, which solves the problem that the existing method for preparing N-methylpiperazine uses diethanolamine, a dangerous product, as a raw material, which is harmful to human health and the environment, and the raw material for preparing diethanolamine is not easy. Technical problems such as obtaining, the preparation method includes ester aminolysis reaction and hydrogenation reduction reaction, namely, dimethyl oxalate and N-methylethylenediamine undergo aminolysis reaction to generate lactam; and then use the lactam as a reactant , adding catalyst Raney nickel, at a temperature of 150-200 ° C and a pressure of 3.0-5.0 MPa, hydrogen is introduced to carry out hydrogenation reduction reaction, and finally the N-methylpiperazine is obtained, which can be widely used in chemical materials technical field.

The invention discloses a load type catalyst used for combining di-n-propylamine, which utilizes roasted gama-alumina as a carrier. An active component is loaded on the carrier and is composed of nickel, copper, zinc and ruthenium. The weight sum of the nickel, the copper, the zinc, the ruthenium and the roasted gama-alumina is the total weight. The nickel occupies 15% to 25% of the total weight, the copper occupies 5% to 12% of the total weight, the zinc occupies 0.5% to 1% of the total weight, and the ruthenium occupies 0.5% to 1% of the total weight. A preparation method of the load type catalyst for combining the di-n-propylamine and a method for preparing the di-n-propylamine by using the load type catalyst are further disclosed. N-propylamine is added in a raw material cylinder, is gasified and then passes through a fixed bed reactor containing an activated load type catalyst, catalyst disproportionated reaction is conducted under the hydrogen condition, a product is collected after condensation, and rectification is conducted to obtain the di-n-propylamine.

The invention discloses a total synthesis method of amides alkaloid, and belongs to the technical field of the chemistry of natural products. The total synthesis method comprises the following steps: carrying out the synthesis by adopting malonate and 2-bromopropane or 2-bromopropane derivative as raw materials, thereby obtaining isopropyl malonate; (2) carrying out the synthesis by adopting 2-aminopyrrolidine as a raw material, thereby obtaining mid-body 2-amino tetralin pyrrolidine; and (3) synthesizing amides alkaloid 3-isopropyl-nafoxidine[1,2-alpha]pyrimidine-2,4(1H,3H)-diketone and a derivative by adopting the isopropyl malonate and the 2-2-amino tetralin pyrrolidine as a raw material. By adopting the total synthesis method, the defect that the extraction separation process in the natural product is complicated and the yield is low can be overcome, and the demand of perople for further researching the natural product can be satisfied; moreover, the synthesis method is simple in route, raw materials are cheap and easy to obtain, and the yield is relatively high.

The invention discloses a loading-type catalytic agent for synthesizing N-butylethylamine. Gamma-alumina after roasting serves as a carrier, active components composed of Cu and Ni are loaded on the carrier, sum of weight of the Cu, the Ni and the gamma-AI2O3 after roasting is total weight, sum of weight of the Cu and the Ni occupies 25%-38% of the total weight, and ratio of amount of substance of the Cu and the Ni is 0.9-1.5 / 1. The invention further provides a preparation method of the loading-type catalytic agent. A method for synthesizing the N-butylethylamine by using the loading-type catalytic agent is further provided, ethylamine and the n-butylamine are mixed in a mixing tank to obtain mixed liquor which passes through a fixed bed reactor containing activated loading-type catalyticagent after being vaporized, an amine disproportionated reaction is carried out in a hydrogenation condition, products are collected after condensation, and rectification is carried out to obtain theN-butylethylamine.

The invention relates to a flame retardant graft modification method for nylon 66 fabric by a microwave irradiation method. The grafting reaction is carried out by the microwave method, and the flame retardant graft modification method has the advantages of short reaction time, even reaction, and small effect on the performance of the fabric. Allylthiourea is adopted as a grafted monomer, and thus the combustion performance of the grafted nylon 66 fabric is obviously improved; the monomer and the fabric surface are bonded through a chemical bond, the bonding effect is stable and lasting and thus the washability of the fabric is high.