56results about How to "React green" patented technology

The method comprises the following steps: dropwise adding hydrogen peroxide into a mixture of cyclic sulfite, an organic solvent and a solid catalyst to carry out catalytic oxidation reaction, filtering out the solid catalyst after the reaction is finished, standing filtrate for layering, taking an organic layer, and performing distilling and concentrating to obtain a cyclic sulfate product. Cheaphydrogen peroxide is used for directly catalyzing and oxidizing cyclic sulfite to prepare cyclic sulfate, so that on one hand, the reaction is mild and easy to control, and the reaction conversion rate is high; on the other hand, no waste salt is generated, the evaporation capacity of water is small, energy consumption is low, generated waste water is little, and the production process is more environmentally friendly; the used solid catalyst contains an active component, an active auxiliary agent and an oxide carrier, and can be recycled, so that the consumption of noble metals is reduced, and the production cost is greatly reduced; the cyclic sulfate prepared by the method is few in impurities, high in purity and wide in market prospect.

The invention provides a polymerization method for preparing fluorine-containing alternative polymer through a photocatalyst. The polymerization method includes following steps: (1), adding two bifunctional monomers A and B, organic photocatalyst and promoter into a mixed organic solvent system, stirring in a reaction container to enable the system to be homogeneous, and sealing the reaction container after deoxidizing for four times; (2), setting temperature of the reaction container to 25 DEG C, and allowing polymerization reaction for 1-200h through photocatalysis in a condition that rotating speed is 1500-2000rpm; (3), after the reaction is finished, adding tetrahydrofuran to dilute a polymerization system, pouring into methanol, precipitating, suction-filtering, and drying to obtain the fluorine-containing alternative polymer. The organic photocatalyst is used to replace a conventional metal photocatalyst, a free radical step-by-step polymerization novel method which is simple, economical, efficient and environment-friendly is designed, and a brand-new method is provided to obtain various fluorine-containing alternative polymers having different microstructures.

The invention discloses a method for preparing amino-acid ester. In the presence of an oxidant, the method adopts an amine compound and malonic ester as reactants, an iodide as a catalyst and sodium acetate as alkali; a product amino-acid ester is prepared through nucleophilic substitution in a polar solvent; the general formula of the chemical structure of malonic ester is shown in the decstiption; and the iodide is one of I2, TBAI, NIS and IBr. According to the method disclosed by the invention, the reaction activity of the catalyst is high, the reaction conditions are moderate, the application range of substrate is wide, the aftertreatment is convenient, the yield of the target product is high, the preparation process is simple and green and environment-friendly, and the raw materials are widely available.

The invention discloses a preparation method of 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide. The preparation method is characterized in that 2-aminobenzenesul fonamide and tert-butyl nitrite are taken asreaction materials and have a diazo-reaction in a reaction solvent to obtain 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide, and the reaction temperature is 0 DEG C to 50 DEG C. The preparation method has the beneficial effects that the reaction is efficient, the yield is high, the operation is convenient, and the postprocessing is simple; an oxidizing reagent or a catalyst are not required to be added;the reaction condition is mild, the reaction is carried out at a room temperature, the 1,2,3,4-benzoxatriazine-1,1(2H)-dioxide is easy to prepare, and the reaction is green and economical.

The invention relates to benzotriazole compounds and a preparing method thereof. o-phenylenediamine or an o-phenylenediamine compound n-butyl nitrite are adopted as reaction raw materials and are subjected to an intramolecular diazo-reaction at room temperature in a reaction solvent to obtain the corresponding benzotriazole compound. According to the method, the range of substrates is wide, reaction conditions are mild, after-treatment is simple, and a product yield and quality are high. A novel synthesis route and method for the benzotriazole compounds are developed. The benzotriazole compounds have good application potentials and research value.

The invention discloses a synthesis method of a C-3-position difluoromethyl-substituted quinoxalinone derivative. The method comprises the steps of dissolving a quinoxalinone derivative, a bromodifluoromethyl compound, a photocatalyst, an inorganic base and an organic amine in an organic solvent for a reaction for 6-36 hours at the temperature of 20-60 DEG C under the irradiation of visible light;after the reaction is finished, carrying out posttreatment on a reaction system to obtain a target product, namely the C-3-position difluoromethyl-substituted quinoxalinone derivative. According to the method, light is adopted as a reaction energy source to realize C-3 difluoro methylation of quinoxalinone, so that the reaction is safer, environmentally friendly and lower in cost, the applicationrange of reaction substrates is expanded, and synthesis methods of C-3 substituted quinoxalinone compounds are diversified.

The invention discloses a preparation method of a 1,3-diene derivative having aggregation-induced emission property and belongs to the technical field of synthesis of compounds. The derivatives have strong aggregation-induced emission property and the preparation of the derivatives is achieved by carrying out oxydehydrogenation coupling reaction on a substrate olefin under the catalysis of palladium in the presence of oxygen serving as an oxidant. The method has the characteristics of mild reaction condition, simple operation, use of easily available raw materials, high selectivity and environmental friendliness and is used for solving the deficiencies in the prior art that the synthetic efficiency of the compounds having the aggregation-induced emission property is low and the cost is high.

The invention discloses a synthesis method of a C-3 alkyl substituted coumarin derivative. The synthesis method comprises the following steps: dissolving a coumarin derivative shown as a formula (I),an N-alkyloxyphthalimide compound shown as a formula (II), a photocatalyst and a proton acid in an organic solvent; reacting under visible light irradiation at a temperature of 20 to 60 DEG C for 3 to36 hours; after the reaction is finished, performing post-treatment on a reaction system to obtain a target product of the C-3 alkyl substituted coumarin derivative shown as a formula (III), whereinthe reaction formulas are shown in the description; in the formulas (I) and the formula (III), the substituent R1 is H, methyl, methoxy, fluorine, chlorine or bromine; in the formula (II) and the formula (III), the substituent R2 is linear alkyl or naphthenic alkyl of with 1 to 8 carbon atoms. The synthesis method realizes the C-3alkylation of coumarin with light as reaction energy, makes the reaction safer, more environmentally friendly and cheaper, expands the application range of the reaction substrate, and enriches the synthesis method of a C-3 substituted coumarin compound.

The invention discloses a platinum-carbon catalyst, a preparation method thereof and an application of the platinum-carbon catalyst in a cathode catalyst of a fuel cell, and the preparation method comprises the following steps: 1) preparing an aqueous solution of sugar, adjusting the pH value to 5-9, then carrying out hydrothermal carbonization reaction by adopting the solution, and drying to obtain a carbon carrier material; 2) preparing a mixed solution of glucose and a platinum precursor, and heating the mixed solution; 3) adding a dispersion liquid of a carbon carrier material, adjusting the pH value to 3-10, heating, and reacting; 4) cooling and separating a reaction product to obtain a platinum-carbon catalyst precursor; and 5) calcining to obtain the platinum-carbon catalyst. According to the preparation method, cheap saccharides are used as precursors to prepare the carbon carriers, pretreatment is not needed, nano platinum particles can be well dispersed, and the catalytic performance of the prepared catalyst on oxygen reduction is superior to that of a commercial platinum-carbon catalyst. Moreover, the method is green in reaction, simple in preparation process and suitable for industrial production, and has a wide application prospect in the field of fuel cell catalysts.

The invention provides a PLA-BAT blending modified degradable material. A modified starch is added into a PLA-BAT blending polymer, so that common modified starch is rich in epoxy groups, and the compatibility between PLA and PBAT is better due to the introduction of the epoxy groups. Through modification, the PLA-BAT blend has relatively good mechanical properties, and also has relatively good degradation properties at the same time. Furthermore, the polyglycidyl methacrylate is selected to graft the starch, the reaction between the polyglycidyl methacrylate and the starch is simple, besidesa small amount of necessary catalyst, other additional auxiliaries, toxic reagents or other organic solvents are not needed, and the reaction is green and closer to the concept of health. The invention provides a practical optional material in degradable materials, and the degradable material has certain application universality.

The invention discloses an indolizine derivative and a preparation method thereof. A cheap copper compound is taken as a catalyst, a pyridine derivative, an olefinic derivative and a heavy nitrogen derivative are taken as reactants, and the catalyst and the reactants are subjected to cyclization reaction in a mixed solvent to obtain a product indolizine. The catalyst prepared with the method disclosed by the invention is cheap, can be easily obtained, is high in reaction activity, is moderate in reaction conditions, only needs to be carried out in the air, has a wide primer applicable range and is convenient in aftertreatment, and a final product can be obtained through simple column chromatography after reaction is finished. A target product has the advantages of high yield, simple preparation process, environment protection and wide raw material resource. The indolizine derivative conforms to the requirement and the direction of modern green chemistry development and has a potential industrial application value.

The present invention discloses a synthesis method of a perfluoroalkyl-substituted polycyclic quinazolinone derivative. The synthesis method comprises the following steps: dissolving a quinazolinone derivative containing an inactive double bond as shown in a formula (I) and perfluoroalkyl sodium sulfinate as shown in a formula (II) in a solvent, carrying out a reaction under an open condition at room temperature under visible light irradiation for 3-24 hours, and after the reaction is finished, performing post-treatment on the reaction system to obtain the perfluoroalkyl-substituted polycyclic quinazolinone derivative as shown in a formula (III). According to the present invention, light is adopted as the reaction energy source, the inactive double bond-containing quinazolinone perfluoroalkylation / cyclization reaction is achieved without any additive, the process is safe, the cost is low, the operation is simple and convenient, and the green synthesis method of the perfluoroalkyl-substituted polycyclic quinazolinone derivative is provided.

The invention discloses a synthetic method for C-3 position alkyl-substituted quinoxalinone derivatives. The method comprises the following steps: under a N2 protective atmosphere and visible light irradiation, adding one quinoxalinone derivative represented by a formula (I), one N-alkylcarbonyloxyphthalimide compound represented by a formula (II), a photocatalyst and an additive into an organic solvent, performing a reaction, and after the reaction is completed, performing post-treatment on the reaction liquid system to obtain one C-3 position alkyl-substituted quinoxalinone derivative represented by a formula (III), wherein a reaction formula is shown in the description, in the formula (I) and (III), the substituent group R<1> is one selected from the group consisting of H, C1-C3 alkyl,benzyl and propargyl, and the substituent group R<2> is one selected from the group consisting of H, methoxy, fluoro, chloro, bromo and trifluoromethyl; and in the formula (II) and (III), the substituent group R<3> is one selected from the group consisting of C1-C8 linear or branched alkyl, C5-C6 cycloalkyl and a C3-C5 alkenyl. The method provided by the invention uses visible light as an energy source for the reaction, so that the reaction conditions are milder, and the production operation is safer; and the substrate of the reaction is cheap and easy to obtain, so that the production costs can be reduced.

The invention discloses a synthesis method of an alpha-F-beta-OH-carbonyl compound. The synthesis method comprises the following steps: dissolving an unsaturated ketone compound shown in formula (I) and an N-F reagent in a reaction solvent, reacting for 5 to 25 hours at the temperature of 30 to 100 DEG C, after the reaction is ended, performing the after-treatment for a reaction solution to obtainan alpha-F-beta-OH-carbonyl compound as shown in formula (II), wherein the reaction formula is shown as follows: (shown in the description) In formula (I) and (II), substituent groups R1 and R2 are respectively independently selected from phenyl, substituted phenyl, thienyl or furyl; and the substituent group of the substituted phenyl is at least one of C1 to C3 alkyl, C1 to C3 alkoxy, nitro, trifluoromethyl, fluorine, chlorine and bromine. The N-F reagent is used as a fluorine source and Lewis acid, no additional catalyst is used, so that the reaction is more environment-friendly, and the cost is lower; and the method for synthesizing the alpha-F-beta-OH-carbonyl compound provided in the invention has the advantages of easy availability of raw materials, mild reaction conditions, no needof other catalysts, good reaction selectivity, simplicity in operation and the like.

The invention discloses a preparation method of cyanomethyl ester. In the presence of an oxidizing agent, a carboxylic acid compound and cyanoacetic acid are used as reactants, iodide is used as a catalyst, and sodium acetate is used as alkali, so as to prepare the cyanomethyl ester in a mixed solvent through nucleophilic substitution. According to the method, the reactivity of the catalyst is high, reaction conditions are mild, the application range of substrates is wide, the postprocessing is convenient, the yield of target products is high, a preparation process is simple, green and environmentally friendly, and the sources of used raw material are wide.

The invention provides a substituted tetrahydroquinoline derivative and a hydrolysis product thereof, and provides a method of preparing the above-mentioned compound with visible-light-responding surface-modified titanium dioxide catalyst and an application of the tetrahydroquinoline derivative and the hydrolysis product thereof in the fields of antibacterial medicines. The compound in the invention is wide in anti-bacterial activity, is prepared with the surface-modified titanium dioxide, which is low in cost and easy to obtain and is stable and toxic-free, as the catalyst, so that the tetrahydroquinoline compound can be synthesized with visible light, is green in reactions and is environment-friendly. In addition, by means of introduction of other active groups into a tetrahydroquinoline ring, new tetrahydroquinoline derivative having the anti-bacterial activity can be prepared.

The invention discloses a method for reducing the biodiesel condensation point through an ultraviolet light irradiation method, and belongs to the field of new energy chemistry.The method includes the following steps that a certain amount of biodiesel is weighed and put into an ultraviolet light reactor, a magnetic stirring function is added in the ultraviolet light reactor, solvent is added to be mixed with the biodiesel, ultraviolet light irradiation coupled with stirring is started at the normal temperature, and a sufficient ultraviolet light irradiation reaction is conducted.After the reaction is completed, the solvent is evaporated and recovered, and the biodiesel condensation point can be reduced.The method is simple and easy to operate; the used solvent can be recovered and used, and waste is avoided; it is ensured that the reaction is environmentally friendly due to ultraviolet light irradiation; reaction cost is low, the condensation point reducing effect is good, the biodiesel condensation point can be reduced to minus 9.5 DEG C, and the requirement for biodiesel fluidity of general areas can be met.

The invention discloses a synthesis method of an alpha, alpha difluoro gamma hydroxyacetamide derivative, which comprises the following steps: dissolving a bromo difluoro acetanilide compound shown ina formula (II), a photocatalyst and an organic alkali in an olefin derivative shown in a formula (I), reacting at room temperature for 5-24 hours under the irradiation of visible light, and after thereaction is finished, filtering to obtain the alpha, alpha difluoro gamma hydroxyacetamide derivative. A reaction system is subjected to post-treatment to obtain the alpha, alpha difluoro gamma hydroxyacetamide derivative shown in the formula (III), and the reaction formula is shown in the specification, in the formula (I) and the formula (III), a substituent group R1 is C2-C11 linear alkyl, arylor substituted aryl; in the formula (II) and the formula (III), the substituent R2 is H, methyl, methoxy, fluorine, chlorine, bromine or aromatic heterocycle. According to the invention, light is used as a reaction energy source to realize hydroxylation of olefin acetamide, so that the reaction is safer and greener, the cost is lower, the substrate application range of the reaction is expanded, and a simpler and more convenient method for preparing the alpha, alpha-difluoro gamma-hydroxyacetamide compound is provided.

The invention discloses a platinum alloy catalyst, its preparation method and its application in a fuel cell cathode catalyst. The method comprises: 1) preparing a mixed solution of the first reducing agent glucose and the precursor of the first metal component platinum; 2. ) under the condition that the pH value of the mixed solution is 3-10, heating and adding a carbon carrier, and raising the temperature to 80-95°C for reaction; 3) adding the precursor of the second metal component, and reacting; 4) cooling and separating the reaction product; 5) Dissolving the reaction product in water, adding a second reducing agent, heating to 80-95°C, and reacting; 6) cooling and separating the reaction product to obtain a catalyst precursor; 7) calcining to obtain a platinum alloy catalyst. The preparation method of the present invention does not require a large amount of organic solvents, and the reaction conditions are mild. In the aqueous solution, non-toxic and mild glucose is used as the main reducing agent, and a second mild reducing agent is introduced to further coordinate dispersion and reduction to prepare a high-efficiency hydrogen fuel cell. catalyst. It has broad application prospects in the field of fuel cell catalysts.

The invention provides a production method of 1,3-olein-2-palmitin, which is low in production cost, environment-friendly and high in product content. According to the method, Sn-1,3 specific lipase is used as a catalyst, so that palm oil and palmitic acid are subjected to transesterification, and the content of palmitic acid in the grease is increased. Then, the palmitic acid is rearranged at theposition of triglyceride through free invertase, and the content of the triglyceride with the Sn-2 as the palmitic acid is increased. Besides, by alternately using the Sn-1,3 specific lipase and freeconverting enzyme, the content of the triglyceride with the Sn-2 as the palmitic acid can be continuously increased. The method comprises the following steps: mixing the triglyceride rich in Sn-2 position palmitic acid with oleic acid, and replacing the palmitic acid at Sn-1 and Sn-3 position with oleic acid by using the Sn-1,3 specific lipase as the catalyst to obtain high-content 1,3-olein-2-palmitin (OPO).

The invention discloses nano-silver with modified sucrose as a reducing agent and a protective agent and a preparation method thereof. The method comprises the steps that the sucrose modified by periodate is slowly added into a AgNO3 solution, the sucrose modified by the periodate and the AgNO3 solution are mixed and stirred uniformly, and then reaction is carried out at the temperature of 80 DEGC for 12-24 hours so as to obtain nano-silver particles. According to the nano-silver and the preparation method thereof, the modified sucrose serves as the reducing agent and the protective agent forthe nano-silver particles, and therefore the nano-silver and the preparation method thereof have the characteristics of being wide in raw material sources, mild in reaction, green, environmentally friendly and the like.

The invention discloses a nitrogen-doped graphene quantum dot-iron ion composite nano-enzyme and a preparation method and application thereof, and belongs to the technical field of nano-enzymes. The preparation method of the nitrogen-doped graphene quantum dot-iron ion composite nano-enzyme comprises the following steps: synthesizing nitrogen-doped graphene quantum dots by using 1-aminopyrene as a carbon source and a nitrogen source and H2O as a reaction medium through a one-step hydrothermal method, and compounding the nitrogen-doped graphene quantum dots with Fe < 3 + > to obtain the nitrogen-doped graphene quantum dot-iron ion composite nano-enzyme. The nano-composite has the activity of pseudo-peroxidase. The nitrogen-doped graphene quantum dot-iron ion composite nano enzyme can be used as pseudo-peroxidase to distinguish hydroquinone and isomers thereof, and selective colorimetric detection of hydroquinone is realized. The preparation method is simple, and the synthesized nano-enzyme is high in activity.

The invention relates to a pyridyl bridged NNP cobalt complex and an application thereof. A pyridyl bridged tridentate NNP compound is used as a ligand to react with a metal cobalt precursor to obtainthe pyridyl bridged NNP cobalt complex. The complex can be used for catalyzing dehydrogenation condensation of o-phenylenediamine and benzyl alcohol to generate benzimidazole compounds. The method has the advantages of cheap and easily available raw materials, simple operation, few synthesis steps, green reaction and the like.

The invention discloses a photocatalytic oxidation synthesis method of diphenylmethanol ester. The method is characterized in that diphenylmethanol and carboxylic acid are used as reaction substrates,2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) are used as a catalyst, and oxygen is used as an oxidant, in the presence of 3A or 4A molecular sieves, the reaction substrates react in the 1,2-dichloroethane solvent under conditions of room temperature, normal pressure and blue light irradiation, and after the reaction ends, a diphenylmethanol ester compound is obtained by separation treatment. According to the invention, by replacing the traditional heating reaction with light reaction, the energy is saved; and the reaction is environmentally friendly by using oxygen as the oxidant.

The invention discloses a synthesis method of C-3 alkyl-substituted coumarin derivatives, which combines the coumarin derivatives represented by the formula (I), the coumarin derivatives represented by the formula (II) N ‑alkanoyloxyphthalimide compound, photocatalyst and protonic acid are dissolved in an organic solvent, and reacted at 20‑60°C for 3‑36 h under visible light irradiation. After the reaction, the reaction system After post-processing, the C-3 alkyl-substituted coumarin derivative target product shown in formula (III) is obtained; the reaction formula is as follows: In formula (I) and formula (III), the substituent R 1 Is H, methyl, methoxy, fluorine, chlorine or bromine; in formula (II) and formula (III), substituent R 2 It is C1-C8 linear alkyl or cycloalkyl. The invention realizes the C-3 alkylation of coumarin by using light as the reaction energy, makes the reaction safer, greener, and lower in cost, expands the scope of application of the substrate of the reaction, and enriches the coumarins substituted by C-3 Compound synthesis method.

The invention discloses a synthesis method of a C-3-position difluoromethyl-substituted quinoxalinone derivative. The method comprises the steps of dissolving a quinoxalinone derivative, a bromodifluoromethyl compound, a photocatalyst, an inorganic base and an organic amine in an organic solvent for a reaction for 6-36 hours at the temperature of 20-60 DEG C under the irradiation of visible light;after the reaction is finished, carrying out posttreatment on a reaction system to obtain a target product, namely the C-3-position difluoromethyl-substituted quinoxalinone derivative. According to the method, light is adopted as a reaction energy source to realize C-3 difluoro methylation of quinoxalinone, so that the reaction is safer, environmentally friendly and lower in cost, the applicationrange of reaction substrates is expanded, and synthesis methods of C-3 substituted quinoxalinone compounds are diversified.

The invention provides a preparation method of triamcinolone acetonide. The preparation method of triamcinolone acetonide comprises the following steps: S1, enabling tetraene acetate, formic acid and an oxidizing agent to react to obtain a compound I; s2, the compound I, perchloric acid and dibromohydantoin are subjected to a reaction, and a compound II is obtained; s3, the compound II and hydrofluoric acid are subjected to a fluorinated ketal reaction, and a triamcinolone acetonide crude product is obtained. According to the preparation method, the operation steps are simplified, the production cycle is greatly shortened, the discharge of a large amount of chemical wastewater is reduced, the pressure and the cost of treating the wastewater in a factory are saved, the pollution to the environment is reduced, the reaction is green and environment-friendly, the yield and the quality of the product are greatly improved, and the preparation method has a good application prospect.

The invention discloses a photocatalytic oxidation synthesis method of diphenylmethanol ester. The method is characterized in that diphenylmethanol and carboxylic acid are used as reaction substrates,2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) are used as a catalyst, and oxygen is used as an oxidant, in the presence of 3A or 4A molecular sieves, the reaction substrates react in the 1,2-dichloroethane solvent under conditions of room temperature, normal pressure and blue light irradiation, and after the reaction ends, a diphenylmethanol ester compound is obtained by separation treatment. According to the invention, by replacing the traditional heating reaction with light reaction, the energy is saved; and the reaction is environmentally friendly by using oxygen as the oxidant.

The present invention relates to the technical field of drug synthesis, in particular to a method for preparing 2,4,6-triiodoresorcinol, that is, in sulfuric acid methanol solution, using resorcinol as a substrate, potassium iodide as an iodine reagent, and dropping Hydrogen peroxide aqueous solution is added, and the highly active, nascent atomic iodine and resorcinol generated by the oxidation of potassium iodide by hydrogen peroxide react to produce products; the by-products are water and inorganic salts. The method for synthesizing iodophenol of the present invention is an oxidation iodization process, and the highly active iodide iodine chloride generated in the process is immediately generated and consumed by iodine immediately, and the by-products of the reaction are water and potassium sulfate; the reaction is green, efficient, and Safe and controllable.