46results about How to "Gentle production process" patented technology

The purpose of the invention to provide a polymeric acid solution thickener. The thickener has excellent resistance to a high temperature and shearing, and can meet high temperature and deep well construction requirements. The ternary copolymeric acidified fracturing thickener obtained in the invention can be used for thickening an acid solution with the hydrochloric acid concentration of 5-28%, the apparent viscosity of the thickener at room temperature is 100 mPa.s or above, the viscosity retention rate at 90 DEG C still reaches 60% or above, the viscosity at 110 DEG C can still reach 30 mPa. s or above, and the thickener has good thickening and temperature resisting performances. Compared with conventional preparation technologies, a technology disclosed in the invention has the advantages of high production efficiency, simplicity, mild production conditions, easiness in control of the polymerization process, great reduction of the production cost, and easiness in industrial promotion; and the above product has the advantages of good solubility, convenience in transportation, and good application prospect.

The invention discloses a preparation process of dalteparin sodium. The preparation process comprises the following steps: preparing a heparin sodium solution, a heparin degradation fluid, a reducing solution and a crude product, refining, freeze-drying and the like. The average molecular weight of the obtained product is 5,500 to 6,500, the peak molecular weight is 3,500 to 6,000, a component with the molecular weight of less than 3,000 is not greater than 13% , a component with the molecular weight of greater than 8,000 is not greater than 15%, anti-Xa activity is more than or equal to 130IU / mg. The invention has the advantages of rich source of raw materials, high yield, stable and reliable quality, high purity, low cost, simple process, easiness in operation and no waste discharge. The dalteparin sodium has the anticoagulant, antithrombotic, anti-tumor, anti-inflammatory, anti-allergy and blood lipid regulating effects, thereby having a significant curative effect. The dalteparin sodium can be used for preventing preoperative and postoperative thrombosis of general surgery, orthopedic surgery and neurosurgery, effectively preventing venous thromboembolism of ischemic stroke patients, greatly reducing the risk of stroke, effectively preventing the solidification caused by extracorporeal circulation of blood, effectively preventing the instable coronary heart disease, and having a wide usable range.

The invention discloses a method of preparing granular sodium tert-butoxide, which includes the following steps: using metal sodium, tert-butanol and an inert organic solvent as raw materials; adding the tert-butanol and the inert solvent into a reaction kettle and then adding the metal sodium into the reaction kettle; under the protection of a nitrogen gas, refluxing for 8-40 h; at a normal temperature, distilling the tert-butnaol; after totally distilling the tert-butanol, reducing the pressure to -0.08 to -0.098 MPa to distil the remained insert organic solvent; then adjusting the stirringrate of the reaction kettle to 10-80 r / min; reducing the pressure to distil the inert organic solvent; obtaining a residual granular sodium tert-butoxide product in the reaction kettle; cooling the product to less than 40 DEG C to obtain the required granular sodium tert-butoxide. The method can perform a production by using universal chemical equipment. An operation condition is moderate; a protection technique is simple; and the raw materials used are easily obtained. The quality of the product is stable and reliable. The shelf life of the product can be effectively prolonged.

The invention discloses a preparation method of a special soybean protein isolate for a frozen meat product and an application of the preparation method, and belongs to the field of food processing. The preparation method comprises the following steps of: taking low-temperature soybean meal as the raw material, subjecting the soybean meal to alkali extraction and acid precipitation treatment to obtain neutral liquid soybean protein, subjecting the liquid soybean protein to high pressure homogenization and water-bath heating treatment, and subjecting the resulting product to spray drying to obtain the product. When the preparation method disclosed by the invention is applied for preparing the soybean protein isolate, high pressure homogenization and heating are applied to treating the liquid soybean protein in combination to obtain the soybean protein product which is high in nutritional value, good in water and oil holding capacity in a frozen condition, and strong in specificity in the meat product. The method disclosed by the invention is wide in raw material resources, low in cost, simple in needed equipment, safe in operation, and free from toxic and side effects, not only improves the added values of the low-temperature soybean meal and the soybean protein isolate, but also provides a soybean protein additive which is strong in specificity and stabler in functions to a frozen meat product industry, simultaneously greatly reduces the production cost of an enterprise, and has wide application prospect.

The invention discloses a catalyst suitable for synthesizing acrylic acid by an aqueous formaldehyde solution and acetic acid and a preparation and application method of the catalyst. The catalyst is mainly characterized by adopting one or more of activated carbon, aluminum sesquioxide, silicon dioxide or molecular sieve as carriers, and loading phosphorus pentoxide and one or more alkaline-earth metal oxides, wherein phosphorus pentoxide accounts for 1%-20% of the total mass of the catalyst, and the alkaline-earth metal oxides account for 5%-30% of the total weight of the catalyst. The catalyst is prepared by the steps of impregnation, temperature programmed calcination and the like, and a vacuum-ultrasonic impregnation technique is introduced during the preparation process. According to the invention, a fixed bed reactor is adopted for produce acrylic acid continuously under the suitable reaction conditions, the conversion per pass of formaldehyde is up to 35%, and the selectivity of acrylic acid is up to 55%.

The invention provides a method for synthesizing leuprorelin in a full liquid phase, which comprises the following steps: carrying out condensation reaction on R4-Pyr-His (R3)-Trp (Boc)-Ser (tBu)-Tyr (tBu)-D-Leuu-Leg-Pro-NHEt and H-Arg (pbf)-Pro-NHEt to obtain R4-Pyr-His (R3)-Trp (Boc)-Ser (tBu)-Tyr (tBu)-D-Leuu-Leg-Arg (pbf)-Pro-NHEt, and then carrying out reaction on the R4-Pyr-His (R3)-Trp (Boc)-Ser (tBu)-Tyr (tBu Compared with the prior art, the preparation method adopts a full liquid phase synthesis method, the production process is green and mild, any highly toxic and precursor reagent is not used, the purity of the produced product is high, the crude product can reach 90% or above, the cost is greatly reduced, and the preparation method is very suitable for large-scale production.

The invention discloses a manufacturing method of granular potassium tert-pentylate, comprising the following steps: taking potassium metal, tert-amyl alcohol and inert organic solvent as raw materials; adding tert-amyl alcohol and inert organic solvent into a kettle; then, adding potassium metal into the kettle; after reflowing for 8-40 hours under the protection of nitrogen, evaporating tert-amyl alcohol at normal pressure; after tert-amyl alcohol is completely evaporated, decompressing to -0.08--0.098 MPa, and evaporating residual organic solvent; then, regulating the stirring rate of the kettle to 10-80 turns / min; decompressing to evaporate inert organic solvent, and leaving granular potassium tert-pentylate products in the kettle; and cooling to be below 40 DEG C to obtain the granular potassium tert-pentylate. The invention can carry out production by using general chemical equipment, has moderate operation condition, simple production technology, convenient and abundant raw material, and stable and reliable product quality and can effectively prolong the quality guarantee period of the product.

The invention discloses a method for catalytically oxidizing acetophenone. The method comprises the step of contacting acetophenone, hydrogen peroxide and a catalyst. The method is characterized in that the catalyst contains titanium silicalite molecular sieves and multi-metal oxyacid and / or multi-metal oxysalt. The method is environment-friendly, is simple in production process and is beneficial to industrial production and application.