41results about How to "Green synthesis" patented technology

The invention provides a method for synthesizing silver nanoclusters by the aid of single-stranded DNA (deoxyribonucleic acid) used as a template, and belongs to the technical field of nano materials. By the method, problems of complicated production and excessively high cost of nano-silver for detecting mercury ions at present are solved. The method for synthesizing the silver nanoclusters by the aid of the single-stranded DNA used as the template is characterized in that the single-stranded DNA containing cytosine and guanine is used as the template and is mixed with Ag<+> solution to obtain a mixture, reducing agents are added into the mixture, and the fluorescent silver nanoclusters can be acquired after reduction reaction is performed on the mixture with the reducing agents. The method has the advantages that polyinosinic acid (PI) and polycytidylic acid (PC) which are commercially available are used as the template in the simple, low-cost, environment-friendly and reliable method for synthesizing the silver nanoclusters; fluorescence is utilized, and fluorescent silver nanocrystals are synthesized from the polyinosinic acid, the polycytidylic acid and the like without special design or preprocessing; and the novel silver nanoclusters are excellent in selectivity and sensitivity, can be applied to detecting Hg<2+>, and are feasible and have a future development prospect in the aspect of monitoring pollutants in water.

The invention discloses 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole, a preparation method and application thereof in preparation of medicine and belongs to the field of medicinal chemistry. A pyrimidine parent nucleus and a 1,2,3-triazole activity unit are combined by using classical click chemistry to simply and efficiently synthesize the 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole in an environment-friendly manner. The 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole have a structure general formula as shown in the specification. In vitro anticancer activity tests show that the compounds have a certain inhibition effect on many tumor cells including EC-109, MCF-7, MGC-803 and B16 and can be applied to preparation of an antitumor medicine, as a further developed candidate or lead compound.

The invention relates to a method for synthesizing paranitroanisole. The raw materials used by the method are green chemicals dimethyl carbonate (DMC) and p-nitrophenol, and the catalyst is NaY molecular sieve, activated aluminum oxide or activated carbon which is impregnated by alkali metals or alkaline-earth metal compounds. Good conversion rate of the raw materials and good selectivity of target products can be obtained by using the method provided by the invention under the reaction conditions that: the temperature is between 90 and 200 DEG C, and the reaction time is between 1 and 5 hours; the mol ratio of the p-nitrophenol to the dimethyl carbonate of the raw materials is between 1 to 5 and 1 to 15, and the amount of the catalyst is 2 to 20 percent of the mass of the raw materials, wherein, the conversion rate of the p-nitrophenol can reach over 64 percent, and the selectivity of the paranitroanisole can reach 100 percent. The method takes the DMC as a methylated reagent to actually realize a green synthetic route, takes solid alkali as the catalyst, and is superior to the prior synthetic method of homogeneous catalysis or phase-transfer catalysis; and the catalyst is simple to separate and can be reused.

The invention discloses a method for separating a 5-hydroxymethyl furfural and 2,5-diformylfuran mixture; the method comprises the steps: dissolving the 5-hydroxymethyl furfural and 2,5-diformylfuran mixture in an organic solvent, then adding a deep-eutectic solvent, stirring and mixing evenly at room temperature, and splitting phases; and taking an organic phase, removing the organic solvent under a reduced pressure condition, and thus obtaining 2,5-diformylfuran. The method has the advantages of simple purification process, mild conditions, easy amplification, environmental friendliness, high product purity and the like.

The invention discloses a preparation method of a 1,3-diene derivative having aggregation-induced emission property and belongs to the technical field of synthesis of compounds. The derivatives have strong aggregation-induced emission property and the preparation of the derivatives is achieved by carrying out oxydehydrogenation coupling reaction on a substrate olefin under the catalysis of palladium in the presence of oxygen serving as an oxidant. The method has the characteristics of mild reaction condition, simple operation, use of easily available raw materials, high selectivity and environmental friendliness and is used for solving the deficiencies in the prior art that the synthetic efficiency of the compounds having the aggregation-induced emission property is low and the cost is high.

The invention relates to a novel microorganism namely pseudomonas monteilii CM strain producing hydantoinase and N-carboxamide hydrolase at the same time, a preparation method of the strain, and an application of the strain to synthesis of D(-)-4-hydroxyphenylglycine. The invention screens out a strain which can produce high-activity hydantoinase and N-carboxamide hydrolase. The hydantoinase and the N-carboxamide hydrolase prepared from the strain are used for catalyzing D, L-4-hydroxyphenyl hydantoin for synthesis of the D(-)-4-hydroxyphenylglycine, the conversion rate can reach 99% or above,and a new green high-efficiency convenient method for synthesizing the D(-)-4-hydroxyphenylglycine is provided.

The invention discloses a preparation method of a NbSe2 / CeNbO4 nanocomposite, which comprises the steps of material preparation, ball milling, drying, and sintering. The prepared NbSe2 / CeNbO4 has mixed morphology of nanometer sheets and nanometer particle balls, wherein the nanometer sheets are NbSe2 hexagonal sheets, and the nanometer particle balls are CeNbO4 microparticles; the nanometer sheets have a radial dimension of 3 microns, and have a thickness of 200 nm; the CeNbO4 nanometer particle balls are uniform in size, and have a particle size of about 80 nm. The method of the invention adopts simple solid phase reaction in situ synthesis to obtain the NbSe2 / CeNbO4 nanometer lubrication composite material with special morphology and different sizes. The preparation method of the NbSe2 / CeNbO4 nanocomposite of the invention is simple and practical, mild in reaction conditions, green and pollution-free in process, low in cost, safe and easily available in reagents. When the composite material is used as a lubricating oil additive, the composite material has excellent stability and dispersibility, can effectively improve the friction performance of lubricating oil, and has very good practicality and economical efficiency.

The invention provides a laser preparation method of a CoOOH nanosheet with rich oxygen vacancies. The laser preparation method comprises the following steps of: carrying out surface treatment on a metal cobalt target; placing the metal target in alkaline solution well-blended in advance, and utilizing nanosecond laser to irradiate for 20 minutes under room temperature till the solution is changedinto brown sol; using deionized water to wash the brown sol multiple times, then freezing and drying for 24 hours and obtaining the CoOOH nanosheet with rich oxygen vacancies. The laser preparation method provided by the invention has the beneficial effects that the metal target is used as a precursor, the type is simple, no catalyst is used in the synthetic process, the process is fast and environment-friendly, and side products are fewer, so that the catalytic activity and the conductivity of the material are improved; the method is mild, and can be finished under room temperature; comparedwith the traditional synthetic method, the method realizes great reduction of energy consumption and danger in synthesis; the CoOOH nanosheet is wide in application and is applicable to synthesis ofvarious materials; therefore, the development of the laser liquid-phase method for synthesizing the nano material with rich oxygen vacancies in an environment-friendly, fast and high-efficiency mannerconforms to the needs of the current society for low energy consumption and low pollution in material synthesis.

The invention discloses an environment-friendly synthetic method of a 4-ferrocenyl quinoline derivative. The method is prominently characterized in that ethynylferrocene, aromatic aldehyde and aromatic primary amine generate a three-component cyclization reaction in water under the catalysis of a small amount of organic acid, so as to efficiently synthesize the 4-ferrocenyl quinoline derivative in one step. Compared with the prior art, the environment-friendly synthetic method has the advantages that, heavy metal salt and toxic solvent toluene are not used, the inert gas shielding is not required, reaction conditions are mild, the yield is high, the cost is low, the environmental protection is realized, and the like. A new effective way is provided for rich and structurally diverse quinoline metal derivatives, and the method has wide application prospects.

The invention provides a method for synthesizing silver nanoclusters by the aid of single-stranded DNA (deoxyribonucleic acid) used as a template, and belongs to the technical field of nano materials. By the method, problems of complicated production and excessively high cost of nano-silver for detecting mercury ions at present are solved. The method for synthesizing the silver nanoclusters by the aid of the single-stranded DNA used as the template is characterized in that the single-stranded DNA containing cytosine and guanine is used as the template and is mixed with Ag<+> solution to obtain a mixture, reducing agents are added into the mixture, and the fluorescent silver nanoclusters can be acquired after reduction reaction is performed on the mixture with the reducing agents. The method has the advantages that polyinosinic acid (PI) and polycytidylic acid (PC) which are commercially available are used as the template in the simple, low-cost, environment-friendly and reliable method for synthesizing the silver nanoclusters; fluorescence is utilized, and fluorescent silver nanocrystals are synthesized from the polyinosinic acid, the polycytidylic acid and the like without special design or preprocessing; and the novel silver nanoclusters are excellent in selectivity and sensitivity, can be applied to detecting Hg<2+>, and are feasible and have a future development prospect in the aspect of monitoring pollutants in water.

The invention relates to a method for catalytic synthesis of paranitrophenetole. The raw materials used by the method are green chemicals diethyl carbonate (DMC) and p-nitrophenol, and the catalyst is NaY molecular sieve, activated aluminum oxide or activated carbon which is impregnated by alkali metals or alkaline-earth metal compounds. Good conversion rate of the raw materials and good selectivity of target products can be obtained by using the method provided by the invention under given conditions; and the conversion rate of the p-nitrophenol can reach over 64 percent, and the selectivity of the paranitrophenetole can reach 100 percent. The method is superior to the prior synthetic method of homogeneous catalysis or phase-transfer catalysis; and the catalyst is simple to separate and can be reused. Moreover, the method takes the DEC as an ethylized reagent to actually realize a green synthetic route.

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

The invention relates to a preparation method and application of a chiral spiro aminophosphine ligand with a substituent at the 3-position of a pyridine ring. The chiral spiro aminophosphine ligand isa compound shown as a formula 1, or a racemate or an optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly structurally characterized by having a chiral spiroindane skeleton and a pyridine group. The chiral spiro aminophosphine ligand can be synthesized by using a 7-diaryl / alkylphosphino-7'-amino-1,1'-spiroindane compound with a spiro skeleton as a chiral starting material. After the chiral spiro aminophosphine ligand and a transition metal (iridium) salt form a complex, the complex can be used for catalyzing asymmetric catalytic hydrogenation reaction of an alpha-arylamine substituted lactone compound, shows very high catalytic activity (with TON reaching 19000) and enantioselectivity (up to 99% ee), and has practical value.

The invention relates to a waterproof and oil-repellent material, in particular to a waterproof fluorosilicone oil repellent and a one-pot method for synthesizing the same. The chemical formula of thewaterproof fluorosilicone oil repellent is PFPECOOCH2CH2CH2Si(OR)3, wherein R is methyl or ethyl. The synthesis method comprises the following steps: S1, adding 1-1.5 equivalents of allyl alcohol toacyl fluorine structure terminated perfluoropolyether, and performing separation after reaction to obtain perfluoropolyether acid allyl ester with chemical formula of PFPECOOCH2CH=CH2; S2, adding 1.5-2.0 equivalents of alkoxy silane with chemical formula of HSi(OR)3 and 0.1%-0.2% equivalents of a Pt catalyst to perfluoropolyether acid allyl ester, and performing separation after reaction to obtainthe oil repellent. The method is simple, efficient, green and lower in cost, and the synthesized waterproof fluorosilicone oil repellent has good waterproof, oil repellent and abrasion resistant properties.

The invention provides an iron (II) doped bamboo charcoal material, a preparation method thereof, and an application of the iron (II) doped bamboo charcoal material in a reaction of catalytically oxidizing an ethylbenzene compound to synthesize an acetophenone compound. The iron (II) doped bamboo charcoal material disclosed by the invention is simple to prepare, low in cost and good in thermal stability; and the iron (II) doped bamboo charcoal material is used as a catalyst, oxygen is catalyzed to oxidize aromatic hydrocarbon benzyl secondary C-H bonds under the condition of no solvent and no additive, so efficient and high-selectivity synthesis of aromatic ketone compounds is achieved under the mild condition, use of toxic and harmful reagents is effectively avoided, the social requirements of the current green chemical process are met, and the important application value is realized.

The invention relates to a compound with an anti-pollution effect. The compound is PFPE(CH2OCONCH2CH2CH2Si(OR)3)2, wherein the PFPE is -(CF2O)x-(CF2CF2O)y-, and R is methyl or ethyl. According to thecompound disclosed by the invention, by virtue of tests, the contact angle of the compound to water reaches 114 degrees after film formation on a glass slide; and the compound has a contact angle of 72 degrees to n-hexadecane, and belongs to waterproof and oil-repellent materials. Meanwhile, the film-formed glass slide can be rubbed by steel wool under a load of 1kg for 10000 times without obviously reducing the waterproof and oil-repellent properties, so the glass slide has excellent rub resistance. By testing the dynamic friction coefficient, the dynamic friction coefficient reaches 0.03, the smoothness reaches an international level, and the compound also has wide application prospects in the field of other high-end optical device.

The invention discloses a π-conjugated polycyclic aminoisoquinoline compound, a synthesis method and application thereof, and belongs to the fields of organic chemistry and materials science. The invention provides an economical, efficient and green method for synthesizing the novel π-conjugated polycyclic aminoisoquinoline compounds with good atom and reaction steps, and the synthesized novel π-conjugated polycyclic aminoisoquinoline The structure of quinoline compounds has strong fluorescence quantum yield and long photoluminescence lifetime, and can be used in the fields of small molecule fluorescent markers, new optoelectronic materials, etc., and has good application prospects.

The invention discloses a preparation method of a NbSe2 / CeNbO4 nanocomposite, which comprises the steps of material preparation, ball milling, drying, and sintering. The prepared NbSe2 / CeNbO4 has mixed morphology of nanometer sheets and nanometer particle balls, wherein the nanometer sheets are NbSe2 hexagonal sheets, and the nanometer particle balls are CeNbO4 microparticles; the nanometer sheets have a radial dimension of 3 microns, and have a thickness of 200 nm; the CeNbO4 nanometer particle balls are uniform in size, and have a particle size of about 80 nm. The method of the invention adopts simple solid phase reaction in situ synthesis to obtain the NbSe2 / CeNbO4 nanometer lubrication composite material with special morphology and different sizes. The preparation method of the NbSe2 / CeNbO4 nanocomposite of the invention is simple and practical, mild in reaction conditions, green and pollution-free in process, low in cost, safe and easily available in reagents. When the composite material is used as a lubricating oil additive, the composite material has excellent stability and dispersibility, can effectively improve the friction performance of lubricating oil, and has very good practicality and economical efficiency.

The invention discloses a method for separating a 5-hydroxymethyl furfural and 2,5-diformylfuran mixture; the method comprises the steps: dissolving the 5-hydroxymethyl furfural and 2,5-diformylfuran mixture in an organic solvent, then adding a deep-eutectic solvent, stirring and mixing evenly at room temperature, and splitting phases; and taking an organic phase, removing the organic solvent under a reduced pressure condition, and thus obtaining 2,5-diformylfuran. The method has the advantages of simple purification process, mild conditions, easy amplification, environmental friendliness, high product purity and the like.

The invention discloses a method for synthesizing Piragliatin and an analogue of the Piragliatin. Specifically, an aryl halide, an acrylic acid derivative and alkane are used as raw materials, and the Piragliatin and the analogues thereof are efficiently constructed through concerted catalysis of decatungstate and a metal nickel complex. The method comprises the following steps: firstly realizing aryl alkylation of olefin under illumination, then hydrolyzing ester into acid to prepare acyl chloride, and finally condensing the acyl chloride with 2-aminopyrazine to obtain Piragliatin. A novel methodology for alkene alkylarylation is used, and compared with a previous synthesis method, the method has the advantages that the raw materials are commercially available, the steps are simple and efficient, further derivatization is easy, the operation is simple, and the method is suitable for synthesis of a large amount of Piraglidin and analogues thereof.

The invention relates to a preparation method and application of a chiral spirocyclic aminophosphine ligand substituted at the 3-position on a pyridine ring. The chiral spirocyclic aminophosphine ligand substituted at the 3-position on the pyridine ring is a compound shown in Formula 1, or its racemate or optical isomer, or a catalytically acceptable salt thereof, and the main structural feature is that it has Chiral spiroindane skeleton and with pyridine group. The 3-position substituted chiral spirocyclic aminophosphine ligand on the pyridine ring can be composed of 7-diaryl / alkylphosphino-7′-amino-1,1′-spirodihydroindenes with a spiro ring skeleton Synthesized as a chiral starting material. After the chiral spirocyclic aminophosphine ligand substituted at the 3-position on the pyridine ring forms a complex with a transition metal (iridium) salt, it can be used to catalyze the asymmetric catalytic hydrogenation reaction of α-arylamine-substituted lactone compounds. It exhibits high catalytic activity (TON up to 19000) and enantioselectivity (up to 99% ee), and has practical value.

The invention discloses a synthetic method of an ammonium acetate-mediated benzothiazole compound . The synthetic method comprises the steps: adding an o-haloaniline derivative, potassium sulfide, dimethyl sulfoxide, a catalyst, an additive 1 and an additive 2 into a reaction tube, carrying out a stirring reaction at the temperature of 130-150 DEG C, cooling to room temperature after the reactionis finished, and separating and purifying the product to obtain the benzothiazole compound. The invention provides the synthetic method of the benzothiazole compound by taking K2S as a sulfur source,DMSO as a carbon source and an oxidizing agent, an o-haloaniline derivative as a substrate and an ammonium acetate mediated three-component one-pot method. The method has the advantages of fewer reaction steps, mild reaction conditions, good functional group tolerance and the like.

The invention belongs to the technical field of plant extraction and discloses a method for extracting anthocyanin by utilizing a deep eutectic solvent (DES). The method comprises the following steps: uniformly mixing raw material powder containing anthocyanin with the DES, stirring the materials at 30-60 DEG C for 20-60 minutes to enable the materials to react fully, then taking supernatant through centrifugation, and carrying out elution and drying after the supernatant is adsorbed by a macroporous absorption resin column, thus obtaining anthocyanin powder, wherein the DES is a eutectic mixture of quaternary ammonium salts and hydrogen bond donors in a mole ratio of 1 to (10-19). The method has the beneficial effects that the DES can dissolve anthocyanin more effectively as the solubility parameters of the hydrogen bond donors in the DES are very close to the solubility parameters of the basic structure of anthocyanin, while the phase transfer catalysis effects of the hydrogen bond donors (quaternary ammonium salts) have better promoting effects on dissolution of anthocyanin; and therefore, high-purity anthocyanin can be efficiently purified by utilizing the DES.

The invention discloses a synthesis method of a POSS-based reversible thermochromic membrane material, and belongs to the technical field of synthesis of color-changing materials. The invention solves the problem that color-changing materials at the temperature of 80-200 DEG C are few at present. The method comprises the following steps: dissolving POSS in water; adding a chromium salt into the POSS aqueous solution; and stirring at 20-40 DEG C for 1-24 hours, and volatilizing the solvent at 20-80 DEG C to obtain the POSS-based reversible thermochromic membrane material after the solvent is completely volatilized. The POSS-based reversible thermochromic membrane material is synthesized for the first time, the color change range is 80-200 DEG C, the color change is obvious, and the application field of POSS is expanded. According to the method, the POSS-based membrane material with various color changes can be synthesized. The method has the advantages of simple post-treatment method, mild treatment conditions, wide color change range of the membrane material, high color change speed and the like. Water is used as a solvent, the POSS-based color-changing membrane material is generated through low-temperature reaction, and the method is green, environmentally friendly and mild in reaction condition.

The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a preparation method and application of composite nano gold particles. In the present invention, sodium borohydride is used to reduce the gold solution to obtain the gold seed solution, and then the gold seed solution and the gold ion solution are added to the hyaluronic acid solution for heating to make the gold seeds grow, and then the indocyanine green and chitosan are added respectively. sugar solution, the stable composite gold nanoparticles can be prepared. The invention has the characteristics of green color, simple method and mild reaction conditions, and the prepared nanoparticles can be used for photoacoustic synergistic treatment of tumors.

A functionalized UIO-66 / polyurethane composite grouting reinforcement, which consists of: 80-100 parts of polyol polymer, 15-55 parts of flame-retardant inert diluent, 0.5-3 parts of catalyst, and 80-parts of polyisocyanate by mass fraction 100 parts, plasticizer 10‑40 parts, functionalized UIO‑66 5‑35 parts. The polyurethane composite material can effectively avoid the agglomeration of nanometer materials in the matrix, and the synthesis process is simple and efficient. The functionalized UIO‑66 was grafted onto the polyurethane matrix to construct a composite system in which the nanomaterial particles were uniformly dispersed, and the mechanical strength of the consolidated body was significantly enhanced after grouting.

The invention discloses a method for preparing fluorescent silver nanoparticles based on silver mirror reaction. The method comprises the following steps: the preparation concentration is 5 ~ 25 mmol L ‑1 silver ammonia solution; put bovine serum albumin solution in a beaker, then add silver ammonia solution, place it in a water bath, and let it stand for reaction; transfer the reacted test solution to a dialysis bag with a molecular weight cut-off of 2000, and dialyze for 36-48 hours; The dialyzed test solution was centrifuged and centrifuged at 10000-12000 rpm for 10-20 min to obtain a silver nanoparticle dispersion. The method of the present invention selects bovine serum albumin as a template and a reducing agent, and prepares silver nanoparticles by reducing silver ammonia in situ based on the silver mirror reaction principle. The reaction conditions are mild, the equipment is simple, the operation is convenient, no additional reducing agent is needed, and the advantages are green and fast. The resulting silver nanoparticles exhibit fluorescent properties.

The invention belongs to the technical field of organic chemistry, and in particular relates to a preparation method of sulfonamide compounds. The structure of the sulfonamide compounds synthesized by the inventive method 1 H NMR, 13 C NMR characterization and confirmation. The method of the present invention is to react under heating conditions by aryl diazonium salt, sulfur dioxide solid complex and aryl nitroso compound in the presence of a reducing agent in an organic solvent, and form a diazonium salt and sulfur dioxide solid complex The action generates arylsulfonyl free radicals, and then attacks arylnitroso compounds, and the generated hydroxylamine is reduced to obtain sulfonamide compounds. The preparation method of the compound of the present invention has the advantages of mild conditions, simple and efficient, no catalyst, no pre-synthesis of sulfonyl chloride or sodium sulfonate reagents, wide application range of substrates, strong functional group compatibility, easy separation and purification, and excellent industrial performance. and medicinal chemistry application value.

The invention discloses 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole, a preparation method and application thereof in preparation of medicine and belongs to the field of medicinal chemistry. A pyrimidine parent nucleus and a 1,2,3-triazole activity unit are combined by using classical click chemistry to simply and efficiently synthesize the 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole in an environment-friendly manner. The 2,4,6-trisubstituted pyrimidine compounds containing 1,2,3-triazole have a structure general formula as shown in the specification. In vitro anticancer activity tests show that the compounds have a certain inhibition effect on many tumor cells including EC-109, MCF-7, MGC-803 and B16 and can be applied to preparation of an antitumor medicine, as a further developed candidate or lead compound.