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A kind of preparation method and application of composite nano-gold particles

A nano-gold and particle technology, which is applied in the field of preparation of composite gold nano-particles, can solve the problems of poor stability and instability of ICG

Inactive Publication Date: 2021-05-18
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ICG has poor stability, including water instability, thermal degradation and photodegradation

Method used

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  • A kind of preparation method and application of composite nano-gold particles
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  • A kind of preparation method and application of composite nano-gold particles

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A preparation method of gold nano-gold particles, comprising the following steps:

[0039] (1) Preparation of synthetic reaction solution: the preparation concentration is 0.25mmol / L Au 3+ solution (auric acid chloride, HAuCl 4 ·3H 2 O) 20mL was placed in a 50mL flask. Another 3mmol / L gold solution was prepared for use. A sodium borohydride solution with a concentration of 0.1M was prepared and placed in an ice-water bath. Prepare a 1 mg / mL hyaluronic acid solution with ultrapure water and stir overnight.

[0040] (2) Synthesis of gold seed solution: Add 0.6mL sodium borohydride solution (0.1M) into 20mL gold solution (0.25mmol / L) under magnetic stirring, and react at 25°C for 3h.

[0041] (3) Synthesis of gold nanoparticles: Take 700 μL of the gold seed solution in step (2) and add it to 1 mL of hyaluronic acid solution (1 mg / mL), add 100 μL of gold solution (3 mmol / L), and heat at 100 °C for 10 min.

Embodiment 2

[0043] A preparation method of composite gold nanoparticles, comprising the following steps:

[0044] (1) Preparation of solution: first prepare 1% acetic acid solution, use it to prepare 1 mg / mL chitosan solution, put it in a shaker, overnight, and filter the membrane.

[0045] (2) Synthesis of nanoparticles: Take 700 μL of the nano-gold solution suspended in hyaluronic acid in Example 1, add 200 μL of the chitosan solution, and mix slowly to obtain composite gold nanoparticles without ICG. named ACH.

Embodiment 3

[0047]A preparation method of composite gold nanoparticles, comprising the following steps:

[0048] (1) Preparation of solution: first prepare 1% acetic acid solution, use it to prepare 1 mg / mL chitosan solution, put it in a shaker, overnight, and filter the membrane. Disperse indocyanine green in ultrapure water at a concentration of 1 mg / mL.

[0049] (2) Synthesis of nanoparticles: Take 700 μL of the nano-gold solution suspended in hyaluronic acid in Example 1, add 10 μL of indocyanine green solution, mix well, and incubate for 30 minutes. Add 200 μL of chitosan solution and mix slowly to obtain composite gold nanoparticles loaded with ICG. named ACHI.

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Abstract

The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a preparation method and application of composite nano gold particles. In the present invention, sodium borohydride is used to reduce the gold solution to obtain the gold seed solution, and then the gold seed solution and the gold ion solution are added to the hyaluronic acid solution for heating to make the gold seeds grow, and then the indocyanine green and chitosan are added respectively. sugar solution, the stable composite gold nanoparticles can be prepared. The invention has the characteristics of green color, simple method and mild reaction conditions, and the prepared nanoparticles can be used for photoacoustic synergistic treatment of tumors.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a preparation method and application of composite nano gold particles. Background technique [0002] Nanomaterials play an important role in the development of nanoscience and nanotechnology, and nanostructures exhibit different physical and chemical properties compared with small molecules or small-volume materials. Among different types of nanomaterials, metal nanoparticles, especially gold nanoparticles, have attracted great interest from researchers in different fields, mainly due to the unique properties of gold nanoparticles (high X-ray absorption coefficient, easy synthesis, precise particle control physicochemical properties, unique tunable optics, and distinct electronic properties). [0003] Gold is one of the earliest metals discovered by humans, and its research and application have a long history. The first batch of information about co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/50A61K47/36A61P35/00
CPCA61K9/5036A61K41/0052A61P35/00A61K2300/00
Inventor 高瑜朱立胜王俊李旭东陈海军
Owner FUZHOU UNIV
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